메뉴 건너뛰기




Volumn 36, Issue 2, 2013, Pages 133-140

Pharmacology of the new target-specific oral anticoagulants

Author keywords

Apixaban; Dabigatran; Edoxaban; Oral anticoagulants; Pharmacodynamics; Pharmacokinetics; Pharmacology; Rivaroxaban; Target specific anticoagulants

Indexed keywords

AMIODARONE; ANTICOAGULANT AGENT; APIXABAN; ATORVASTATIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CARBAMAZEPINE; CLARITHROMYCIN; CYCLOSPORIN; DABIGATRAN ETEXILATE; DIGOXIN; EDOXABAN; GLYCOPROTEIN P INHIBITOR; HYPERICUM PERFORATUM EXTRACT; KETOCONAZOLE; LOPERAMIDE; NELFINAVIR; PHENOBARBITAL; PHENYTOIN; PYRROLE DERIVATIVE; QUINIDINE; RIFAMPICIN; RITONAVIR; RIVAROXABAN; TACROLIMUS; TAMOXIFEN; THROMBIN INHIBITOR; UNINDEXED DRUG; VERAPAMIL; WARFARIN; XIMELAGATRAN; THROMBIN;

EID: 84881479575     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-013-0929-5     Document Type: Article
Times cited : (39)

References (52)
  • 1
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
    • 19071881 10.2165/0003088-200948010-00001 1:CAS:528:DC%2BD1MXis12nt7g%3D
    • Eriksson BI, Quinlan DJ, Weitz JI (2009) Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet 48:1-22
    • (2009) Clin Pharmacokinet , vol.48 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 2
    • 24344448633 scopus 로고    scopus 로고
    • Direct thrombin inhibitors
    • 16148288 10.1056/NEJMra044440
    • Di Nisio M, Middeldorp S, Buller HR (2005) Direct thrombin inhibitors. NEJM 353(10):1028-1040
    • (2005) NEJM , vol.353 , Issue.10 , pp. 1028-1040
    • Di Nisio, M.1    Middeldorp, S.2    Buller, H.R.3
  • 3
    • 32544453399 scopus 로고    scopus 로고
    • New anticoagulants: Anti IIa vs. Anti Xa - Is one better?
    • 16475045 10.1007/s11239-006-5579-4 1:CAS:528:DC%2BD28XhtlGktrc%3D
    • Bauer KA (2006) New anticoagulants: Anti IIa vs. Anti Xa - is one better? J Thromb Thrombolysis 21(1):67-72
    • (2006) J Thromb Thrombolysis , vol.21 , Issue.1 , pp. 67-72
    • Bauer, K.A.1
  • 4
    • 0345414673 scopus 로고    scopus 로고
    • Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomized controlled trial
    • Executive Steering Committee on behalf of the SPORTIF III Investigators 10.1016/S0140-6736(03)14841-6
    • Executive Steering Committee on behalf of the SPORTIF III Investigators (2003) Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomized controlled trial. Lancet 362:1691-1698
    • (2003) Lancet , vol.362 , pp. 1691-1698
  • 6
    • 0037171819 scopus 로고    scopus 로고
    • Structured-based design of novel potent nonpeptide thrombin inhibitors
    • 11960487 10.1021/jm0109513 1:CAS:528:DC%2BD38Xit1OgsLs%3D
    • Hauel NH, Nar H, Priepke H, Ries U, Stassen JM, Wienen W (2002) Structured-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem 45:1757-1766
    • (2002) J Med Chem , vol.45 , pp. 1757-1766
    • Hauel, N.H.1    Nar, H.2    Priepke, H.3    Ries, U.4    Stassen, J.M.5    Wienen, W.6
  • 7
    • 34250030035 scopus 로고    scopus 로고
    • Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rates
    • 10.1111/j.1538-7836.2007.02526.x 1:CAS:528:DC%2BD2sXntl2ktrY%3D
    • Wienen W, Stassen JM, Priepke H et al (2007) Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rates. Thromb Haemost 5(6):1237-1242
    • (2007) Thromb Haemost , vol.5 , Issue.6 , pp. 1237-1242
    • Wienen, W.1    Stassen, J.M.2    Priepke, H.3
  • 8
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • 18399711 10.2165/00003088-200847050-00001 1:CAS:528:DC%2BD1cXntVWgsbw%3D
    • Stangier J (2008) Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 47(5):285-295
    • (2008) Clin Pharmacokinet , vol.47 , Issue.5 , pp. 285-295
    • Stangier, J.1
  • 9
    • 77957696662 scopus 로고    scopus 로고
    • Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombin
    • 20671233 10.1161/ATVBAHA.110.203604 1:CAS:528:DC%2BC3cXhtFKlsrrF
    • Eisert WG, Hauel N, Stangier J, Wienen W, Clemens A, vanRyn J (2010) Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler Thromb Vasc Biol 30:1885-1889
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1885-1889
    • Eisert, W.G.1    Hauel, N.2    Stangier, J.3    Wienen, W.4    Clemens, A.5    Vanryn, J.6
  • 10
    • 84881481397 scopus 로고    scopus 로고
    • Pradaxa prescribing information
    • Pradaxa prescribing information (2012) http://bidocs.boehringer- ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/ Prescribing%20Information/PIs/Pradaxa/Pradaxa.pdf. Accessed 9 Oct 2012
    • (2012)
  • 11
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • 19717844 10.1056/NEJMoa0905561 1:CAS:528:DC%2BD1MXhtFOjsLnN
    • Connolly SJ et al (2009) Dabigatran versus warfarin in patients with atrial fibrillation. NEJM 361(12):1139-1151
    • (2009) NEJM , vol.361 , Issue.12 , pp. 1139-1151
    • Connolly, S.J.1
  • 12
    • 79958077792 scopus 로고    scopus 로고
    • Drug and dietary interactions of warfarin and novel oral anticoagulants: An update
    • 21359645 10.1007/s11239-011-0561-1 1:CAS:528:DC%2BC3MXjtFWhurw%3D
    • Nutescu E, Chuatrisorn I, Hellenbart E (2011) Drug and dietary interactions of warfarin and novel oral anticoagulants: an update. J Thromb Thrombolysis 31:326-343
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 326-343
    • Nutescu, E.1    Chuatrisorn, I.2    Hellenbart, E.3
  • 13
    • 37149005153 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran in healthy elderly subjects
    • 18076218 10.2165/00003088-200847010-00005 1:CAS:528:DC%2BD1cXhvF2qu7s%3D
    • Stangier J, Stahle H, Rathgen K et al (2008) The pharmacokinetics, pharmacodynamics and tolerability of dabigatran in healthy elderly subjects. Clin Pharmacokinet 47(1):47-59
    • (2008) Clin Pharmacokinet , vol.47 , Issue.1 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3
  • 14
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • 18006647 10.1124/dmd.107.019083 1:CAS:528:DC%2BD1cXht1yku7o%3D
    • Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Rother W (2008) The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans. Drug Metab Dispos 36:386-399
    • (2008) Drug Metab Dispos , vol.36 , pp. 386-399
    • Blech, S.1    Ebner, T.2    Ludwig-Schwellinger, E.3    Stangier, J.4    Rother, W.5
  • 15
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • 17506785 10.1111/j.1365-2125.2007.02899.x 1:CAS:528:DC%2BD2sXhtFKis7%2FE
    • Stangier J, Rathgen K, Stahl H, Gansser D, Roth W (2007) The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 64:292-303
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahl, H.3    Gansser, D.4    Roth, W.5
  • 16
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate. An open-label, parallel-group, single-centre study
    • 20214409 10.2165/11318170-000000000-00000 1:CAS:528:DC%2BC3cXlsFCktLg%3D
    • Stangier J, Rathgen K, Stahle H, Mazur D (2010) Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate. An open-label, parallel-group, single-centre study. Clin Pharmacokinet 49(4):259-268
    • (2010) Clin Pharmacokinet , vol.49 , Issue.4 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Mazur, D.4
  • 17
    • 84874114340 scopus 로고    scopus 로고
    • Removal of dabigatran by hemodialysis
    • 23219111 10.1053/j.ajkd.2012.08.047 1:CAS:528:DC%2BC38Xhsl2isr7P
    • Chang DN, Dager WE, Chin AI (2013) Removal of dabigatran by hemodialysis. Am J Kid Dis 61(3):487-489
    • (2013) Am J Kid Dis , vol.61 , Issue.3 , pp. 487-489
    • Chang, D.N.1    Dager, W.E.2    Chin, A.I.3
  • 18
    • 57449098437 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment
    • 10.1177/0091270008324179
    • Stanger J, Stahle H, Rathgen K et al (2008) The pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment. J Clin Pharmacol. doi: 10.1177/0091270008324179
    • (2008) J Clin Pharmacol
    • Stanger, J.1    Stahle, H.2    Rathgen, K.3
  • 19
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: Clinical implications
    • 12489979 10.2165/00003088-200342010-00003 1:CAS:528: DC%2BD3sXptVymuw%3D%3D
    • Lin JH, Yamazaki M (2003) Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet 42(1):59-98
    • (2003) Clin Pharmacokinet , vol.42 , Issue.1 , pp. 59-98
    • Lin, J.H.1    Yamazaki, M.2
  • 20
    • 0036784516 scopus 로고    scopus 로고
    • Interaction of cytochrome P450 3A inhibitors with P-glycoprotein
    • 10.1124/jpet.102.037549 1:CAS:528:DC%2BD38XnsV2qsbY%3D
    • Yasuda K et al (2002) Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharm Exp Ther 303(1):323-332
    • (2002) J Pharm Exp Ther , vol.303 , Issue.1 , pp. 323-332
    • Yasuda, K.1
  • 21
    • 77956492689 scopus 로고    scopus 로고
    • The frequency of prescription of P-glycoprotein-affecting drugs in atrial fibrillation
    • 20553377 10.1111/j.1538-7836.2010.03943.x 1:STN:280: DC%2BC3cbisFOltw%3D%3D
    • Jungbauer L, Dobias C, Stollberger C, Weidinger F (2010) The frequency of prescription of P-glycoprotein-affecting drugs in atrial fibrillation. J Thromb Haemost 8(9):2069-2070
    • (2010) J Thromb Haemost , vol.8 , Issue.9 , pp. 2069-2070
    • Jungbauer, L.1    Dobias, C.2    Stollberger, C.3    Weidinger, F.4
  • 22
    • 77952737706 scopus 로고    scopus 로고
    • Drug and dietary interactions of the new and emerging oral anticoagulants
    • 20584229 10.1111/j.1742-1241.2009.02286.x 1:CAS:528:DC%2BC3cXnsFOmtLk%3D
    • Walenga JM, Adiguzel C (2010) Drug and dietary interactions of the new and emerging oral anticoagulants. Int J Clin Pract 64(7):956-967
    • (2010) Int J Clin Pract , vol.64 , Issue.7 , pp. 956-967
    • Walenga, J.M.1    Adiguzel, C.2
  • 23
    • 24944531701 scopus 로고    scopus 로고
    • Inhibition of factor Xa: A potential target for the development of new anticoagulants
    • 10.2165/00129784-200505050-00001 1:CAS:528:DC%2BD2MXhtFWrurbL
    • Alexander JH, Singh KP (2005) Inhibition of factor Xa: a potential target for the development of new anticoagulants. Am J Cardiovasc Drug 5(5):279-290
    • (2005) Am J Cardiovasc Drug , vol.5 , Issue.5 , pp. 279-290
    • Alexander, J.H.1    Singh, K.P.2
  • 24
    • 0035004409 scopus 로고    scopus 로고
    • Perspectives on factor Xa inhibition
    • 11172669 10.2174/0929867013373822 1:CAS:528:DC%2BD3MXhtVSgtr0%3D
    • Rai R, Sprengeler PA, Elrod KC, Young WB (2001) Perspectives on factor Xa inhibition. Curr Med Chem 8:101-119
    • (2001) Curr Med Chem , vol.8 , pp. 101-119
    • Rai, R.1    Sprengeler, P.A.2    Elrod, K.C.3    Young, W.B.4
  • 25
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939: An oral, direct factor Xa inhibitor- after multiple dosing in healthy male subjects
    • 16328318 10.1007/s00228-005-0043-5 1:CAS:528:DC%2BD2MXhtlajsrrF
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M (2005) Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939: an oral, direct factor Xa inhibitor- after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 61:873-880
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 26
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939: An oral, direct factor Xa inhibitor
    • 15748242 10.1111/j.1538-7836.2005.01166.x 1:CAS:528:DC%2BD2MXjtVymsb4%3D
    • Perzborn E, Strassburger J, Wilmen A et al (2005) In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939: an oral, direct factor Xa inhibitor. J Thromb Haemost 3:514-521
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 27
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939: An oral, direct factor Xa inhibitor
    • 16198660 10.1016/j.clpt.2005.06.011 1:CAS:528:DC%2BD2MXhtVGrsb7L
    • Kubitza D, Becka M, Voith B et al (2005) Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939: an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 78:412-421
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3
  • 28
    • 33645779998 scopus 로고    scopus 로고
    • Effects of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in health subjects
    • 10.1177/0091270006286904 1:CAS:528:DC%2BD28Xksl2ms7k%3D
    • Kubitza D et al (2006) Effects of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in health subjects. J Clin Pharmcol 46(5):549-558
    • (2006) J Clin Pharmcol , vol.46 , Issue.5 , pp. 549-558
    • Kubitza, D.1
  • 29
    • 84881478396 scopus 로고    scopus 로고
    • http://www.xareltohcp.com/sites/default/files/pdf/xarelto-0.pdf#zoom=100. Accessed 9 Oct 2012
  • 30
    • 28744434950 scopus 로고    scopus 로고
    • In vitro metabolism of BAY 59-7939: An oral, direct factor Xa inhibitor [abstract 195]
    • Weinz C, Radtke M, Schmeer K et al (2004) In vitro metabolism of BAY 59-7939: an oral, direct factor Xa inhibitor [abstract 195]. Drug Metab Rev 36(Suppl 1):98
    • (2004) Drug Metab Rev , vol.36 , Issue.SUPPL.1 , pp. 98
    • Weinz, C.1    Radtke, M.2    Schmeer, K.3
  • 31
    • 50249169222 scopus 로고    scopus 로고
    • Rivaroxaban: An oral direct inhibitor of factor Xa
    • 18693206 10.2146/ajhp070624 1:CAS:528:DC%2BD1cXhtFWhtr7E
    • Gulseth M, Michaud J, Nutescu EA (2008) Rivaroxaban: an oral direct inhibitor of factor Xa. Am J Health Syst Pharm 65:1520-1529
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 1520-1529
    • Gulseth, M.1    Michaud, J.2    Nutescu, E.A.3
  • 32
    • 34547110933 scopus 로고    scopus 로고
    • The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban, an oral direct factor Xa inhibitor
    • Abstract
    • Kubitza D, Becka M, Mueck W et al (2006) The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban, an oral direct factor Xa inhibitor. Blood 108:905. Abstract
    • (2006) Blood , vol.108 , pp. 905
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 33
    • 68049089512 scopus 로고    scopus 로고
    • The effect of age and gender on the pharmacology and safety of the oral, direct factor Xa inhibitor
    • Abstract
    • Kubitza D, Becka M, Mueck W et al (2007) The effect of age and gender on the pharmacology and safety of the oral, direct factor Xa inhibitor. J Thromb Haemost 5(Suppl 2):P-T-628. Abstract
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2 , pp. 628
    • Kubitza, D.1    Becka, M.2    Mueck, W.3
  • 34
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • 18832478 10.1124/dmd.108.023143 1:CAS:528:DC%2BD1MXhsVSmtg%3D%3D
    • Raghavan N, Frost CE, Yu Z, He K, Zhang H, Humphreys WG, Pinto D et al (2009) Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 37(1):74-81
    • (2009) Drug Metab Dispos , vol.37 , Issue.1 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3    He, K.4    Zhang, H.5    Humphreys, W.G.6    Pinto, D.7
  • 36
    • 67649369106 scopus 로고    scopus 로고
    • Apixaban, an oral direct factor Xa inhibitor: Multiple-dose safety, pharmacokinetics, and pharmacodynamics in healthy subjects
    • Abstract
    • Frost C, Yu Z, Moore K et al (2007) Apixaban, an oral direct factor Xa inhibitor: multiple-dose safety, pharmacokinetics, and pharmacodynamics in healthy subjects. J Thromb Haemost 5(Suppl 2):PT633. Abstract
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2 , pp. 633
    • Frost, C.1    Yu, Z.2    Moore, K.3
  • 37
    • 84872260247 scopus 로고    scopus 로고
    • Apixaban, an oral, direct factor Xa inhibitor: Single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    • 10.1111/j.1365-2125.2012.04369.x
    • Frost C, Wang J, Nepal S, Schuster A, Barrett YC, Mosqueda-Garcia R, Reeves RA, LaCreta F (2012) Apixaban, an oral, direct factor Xa inhibitor: single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol. doi: 10.1111/j.1365-2125.2012.04369.x
    • (2012) Br J Clin Pharmacol
    • Frost, C.1    Wang, J.2    Nepal, S.3    Schuster, A.4    Barrett, Y.C.5    Mosqueda-Garcia, R.6    Reeves, R.A.7    Lacreta, F.8
  • 38
    • 77956332973 scopus 로고    scopus 로고
    • Food does not affect the pharmacokinetics of apixaban, an oral, factor Xa inhibitor
    • Abstract
    • Frost C, Yu Z, Shenker A et al (2008) Food does not affect the pharmacokinetics of apixaban, an oral, factor Xa inhibitor. Can J Clin Pharmacol 15:e469. Abstract
    • (2008) Can J Clin Pharmacol , vol.15 , pp. 469
    • Frost, C.1    Yu, Z.2    Shenker, A.3
  • 39
    • 76749166335 scopus 로고    scopus 로고
    • In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition and induction studies
    • 19940026 10.1124/dmd.109.029694 1:CAS:528:DC%2BC3cXjt1Ort7c%3D
    • Wang L, Zhang D, Raghavan N et al (2010) In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition and induction studies. Drug Metab Dispos 38:448-458
    • (2010) Drug Metab Dispos , vol.38 , pp. 448-458
    • Wang, L.1    Zhang, D.2    Raghavan, N.3
  • 40
    • 77749289263 scopus 로고    scopus 로고
    • Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development
    • 20135071 10.1160/TH09-09-0659 1:CAS:528:DC%2BC3cXksFKrsLg%3D
    • Ufer M (2010) Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost 103:572-585
    • (2010) Thromb Haemost , vol.103 , pp. 572-585
    • Ufer, M.1
  • 41
    • 77952718747 scopus 로고    scopus 로고
    • Single-dose safety and pharmacokinetics of apixaban in subjects with mild or moderate hepatic impairment
    • Abstract
    • Frost CE, Yu Z, Wang J et al (2009) Single-dose safety and pharmacokinetics of apixaban in subjects with mild or moderate hepatic impairment. Clin Pharmacol Ther 85(Suppl 1):S34. Abstract
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.SUPPL.1 , pp. 34
    • Frost, C.E.1    Yu, Z.2    Wang, J.3
  • 42
    • 80053972376 scopus 로고    scopus 로고
    • Effects of age and gender on the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of apixaban
    • Abstract
    • Frost CE, Nepal S, Barrett YC et al (2009) Effects of age and gender on the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of apixaban. J Throm Haemost 7(Suppl 2):PP-MO-407. Abstract
    • (2009) J Throm Haemost , vol.7 , Issue.SUPPL. 2 , pp. 407
    • Frost, C.E.1    Nepal, S.2    Barrett, Y.C.3
  • 43
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • 21870978 10.1056/NEJMoa1107039 1:CAS:528:DC%2BC3MXhtF2ms7rN
    • Granger CB et al (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365:981-992
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1
  • 44
    • 77956333798 scopus 로고    scopus 로고
    • Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
    • Abstract
    • Frost C, Wang J, Nepal S et al (2007) Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor. J Clin Pharmacol 49:1091-1130. Abstract
    • (2007) J Clin Pharmacol , vol.49 , pp. 1091-1130
    • Frost, C.1    Wang, J.2    Nepal, S.3
  • 45
    • 49849099533 scopus 로고    scopus 로고
    • DU-176b, a potent and orally active factor Xa inhibitor: In vitro and in vivo pharmacological profiles
    • 18624979 1:CAS:528:DC%2BD1cXhtFyqurzN
    • Furugohri T, Isobe K, Honda Y et al (2008) DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost 6(9):1542-1549
    • (2008) J Thromb Haemost , vol.6 , Issue.9 , pp. 1542-1549
    • Furugohri, T.1    Isobe, K.2    Honda, Y.3
  • 46
    • 77953787643 scopus 로고    scopus 로고
    • Clinical safety, tolerability, pharmacokinetics and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers
    • 20081065 10.1177/0091270009351883 1:CAS:528:DC%2BC3cXpt1ejtLw%3D
    • Ogata K, Mendell-Harary J, Tachibana M et al (2010) Clinical safety, tolerability, pharmacokinetics and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol 50(7):743-753
    • (2010) J Clin Pharmacol , vol.50 , Issue.7 , pp. 743-753
    • Ogata, K.1    Mendell-Harary, J.2    Tachibana, M.3
  • 47
    • 79960272135 scopus 로고    scopus 로고
    • Edoxaban: A new oral direct factor Xa inhibitor
    • 21861537 10.2165/11595540-000000000-00000 1:CAS:528:DC%2BC3MXhsVKhu7zP
    • Camm AJ, Bounameaux H (2011) Edoxaban: a new oral direct factor Xa inhibitor. Drugs 71(12):1503-1526
    • (2011) Drugs , vol.71 , Issue.12 , pp. 1503-1526
    • Camm, A.J.1    Bounameaux, H.2
  • 48
    • 79955531668 scopus 로고    scopus 로고
    • Effects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteers
    • 20534818 10.1177/0091270010370974 1:CAS:528:DC%2BC3MXntVCgsLk%3D
    • Mendell J, Tachibana M, Shi M et al (2011) Effects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteers. J Clin Pharmacol 51(5):687-694
    • (2011) J Clin Pharmacol , vol.51 , Issue.5 , pp. 687-694
    • Mendell, J.1    Tachibana, M.2    Shi, M.3
  • 50
    • 77957932391 scopus 로고    scopus 로고
    • Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: Design and rationale for the effective aNticoaGulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48)
    • 20934556 10.1016/j.ahj.2010.06.042 1:CAS:528:DC%2BC3cXht1Kqtr7L
    • Ruff CT, Giugliano RP, Antman EM, Crugnale SE, Bocanegra T, Mercuri M, Hanyok J, Patel I, Shi M, Salazar D, McCabe CH, Braunwald E (2010) Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the effective aNticoaGulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J 160:635-641
    • (2010) Am Heart J , vol.160 , pp. 635-641
    • Ruff, C.T.1    Giugliano, R.P.2    Antman, E.M.3    Crugnale, S.E.4    Bocanegra, T.5    Mercuri, M.6    Hanyok, J.7    Patel, I.8    Shi, M.9    Salazar, D.10    McCabe, C.H.11    Braunwald, E.12
  • 51
    • 84881474467 scopus 로고    scopus 로고
    • http://www.boehringer-ingelheim.ca/content/dam/internet/opu/ca-EN/ documents/humanhealth/product-monograph/Pradax-pm.pdf. Accessed 4 Apr 2013
  • 52
    • 84881480650 scopus 로고    scopus 로고
    • http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Product- Information/human/000829/WC500041059.pdf. Accessed 4 Apr 2013


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.