The effect of rhBMP-2 on pulmonary arterioles remodeling in endotoxin-induced acute lung injury in rats

Clinical and Experimental Medicine

Volumn 13, Issue 3, 2013, Pages 187-192

  Wang, Kunpeng ^a   Gong, Jian ^b   Pei, Ling ^a   Shan, Shimin ^a   Tan, Wenfei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Activated caspase 3; Acute lung injury; Bone morphogenetic protein; Cyclin D1; P21

Indexed keywords

CASPASE 3; CYCLIN D1; ENDOTOXIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN P21; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SODIUM CHLORIDE; SURVIVIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIOLE; ARTERY ENDOTHELIUM; ARTERY INTIMA PROLIFERATION; ARTICLE; ATELECTASIS; BLOOD VESSEL RUPTURE; BLOOD VESSEL WALL; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; EXUDATE; FEMALE; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; LUNG CONGESTION; LUNG PARENCHYMA; MALE; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERIOLE; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; TELANGIECTASIA; TUNICA MEDIA;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; ARTERIOLES; BONE MORPHOGENETIC PROTEIN 2; CELL PROLIFERATION; ENDOTOXINS; FEMALE; HUMANS; LUNG; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; RECOMBINANT PROTEINS;

RATTUS; RATTUS NORVEGICUS;

EID: 84881479104     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-012-0197-2     Document Type: Article

References (16)

1. Rudarakanchana N, Trembath RC, Morrell NW (2001) New insights into the pathogenesis and treatment of primary pulmonary hypertension. Thorax 56:888-890
2. Stephens KE, Ishizaka A, Larrick JW, Raffin TA (1988) Tumor necrosis factor causes increased pulmonary permeability and edema. Comparison to septic acute lung injury. Am Rev Respir Dis 137:1364-1370
3. Pei L, Wang J, Fu W, Sheng ZR (2000) Effects of stress reactions on the plasma TNF-α concentration, oxygen partial pressure in blood and pulmonary arterial pressure in the rats with infectious shock. Nat Med J China 80:66-67
4. Masterson JC, Molloy EL, Gilbert JL, McCormack N, Adams A, O'Dea S (2011) Bone morphogenetic protein signalling in airway epithelial cells during regeneration. Cell Signal 23:398-406
5. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334-1349
6. Kneyber MC, Markhorst DG (2009) Management of acute lung injury and acute respiratory distress syndrome in children: a different perspective. Crit Care Med 37:3192-3193
7. Wheeler AP, Bernard GR (2007) Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 369:1553-1564
8. Ma H, Zhu L, Liu Q, Zhang Z (2003) Discussion on the animal model of endotoxin shock. J Emerg Tradit Chin Med 12:260-261
9. Wagner AE, McIlwraith CW, Martin GS (1982) Effect of intra-articular injection of orgotein and saline solution on equine synovia. Am J Vet Res 43:594-597
10. Lefer AM, Tsao PS, Ma XL, Sampath TK (1992) Anti-ischaemic and endothelial protective actions of recombinant human osteogenic protein (hOP-1). J Mol Cell Cardiol 24:585-593
11. Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104:790-795
12. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX (2003) Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 285:L740-L754
13. Brindle NP, Saharinen P, Alitalo K (2006) Signaling and functions of angiopoietin-1 in vascular protection. Circ Res 98:1014-1023
14. Wong WK, Knowles JA, Morse JH (2005) Bone morphogenetic protein receptor type II c-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 33:438-446
15. Dohi T, Beltrami E, Wall NR, Plllescia J, Altieri DC (2004) Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest 114:1117-1127
16. Marx J (1994) How cells cycle toward cancer. Science 263:319-321