Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3

NeuroMolecular Medicine

Volumn 15, Issue 3, 2013, Pages 504-514

  Cartagena, Casandra M ^a   Phillips, Katie L ^a   Williams, Garry L ^a   Konopko, Melissa ^a   Tortella, Frank C ^a   Dave, Jitendra R ^a   Schmid, Kara E ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

NNZ 2566; Penetrating ballistic like brain injury; Traumatic brain injury

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ANTIINFLAMMATORY AGENT; GAMMA INTERFERON; INTERLEUKIN 6; NNZ 2566; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CONTINUOUS INFUSION; CONTROLLED STUDY; CRYOPROTECTION; DNA SYNTHESIS; DRUG EFFICACY; DRUG SAFETY; MACROPHAGE; MALE; NATURAL KILLER CELL; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PENETRATING BALLISTIC LIKE BRAIN INJURY; PRIORITY JOURNAL; RAT; STEREOTACTIC PROCEDURE; T LYMPHOCYTE; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; TREATMENT RESPONSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEAD INJURIES, PENETRATING; KILLER CELLS, NATURAL; MACROPHAGES; MALE; MICROGLIA; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; UP-REGULATION;

EID: 84881478922     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8236-z     Document Type: Article

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