Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer's disease

NeuroMolecular Medicine

Volumn 15, Issue 3, 2013, Pages 541-548

  Cavallucci, Virve ^a   Berretta, Nicola ^a   Nobili, Annalisa ^a   Nisticò, Robert ^a,b   Mercuri, Nicola B ^a,c   D'Amelio, Marcello ^a,d  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d I Medical School   (Italy)

Author keywords

Alzheimer; Dendritic spine; Long term depression; Synaptic plasticity; Tacrolimus; Tg2576 mice

Indexed keywords

CALCINEURIN; TACROLIMUS;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; DENDRITIC SPINE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; IMMUNOREACTIVITY; INTERNALIZATION; LONG TERM DEPRESSION; MALE; MOLECULAR DYNAMICS; MOUSE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; ANIMALS; CA1 REGION, HIPPOCAMPAL; CALCINEURIN; CASPASE 3; DENDRITES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EXCITATORY POSTSYNAPTIC POTENTIALS; GUANYLATE KINASE; LONG-TERM SYNAPTIC DEPRESSION; MALE; MEMBRANE PROTEINS; METHOXYHYDROXYPHENYLGLYCOL; MICE; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PHOSPHOSERINE; POST-SYNAPTIC DENSITY; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; TACROLIMUS;

EID: 84881475864     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-013-8241-2     Document Type: Article

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