A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes

International Journal of Cardiology

Volumn 167, Issue 4, 2013, Pages 1329-1332

  Hughes, Alun David ^a   Park, Chloe ^a   March, Katherine ^a   Coady, Emma ^a   Khir, Ashraf ^b   Chaturvedi, Nish ^a   Thom, Simon Alistair McGillivray ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Diabetes; Diastolic function; Left ventricle; Thiazolidinediones

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; PIOGLITAZONE; PLACEBO;

ADULT; ANKLE SWELLING; ARTICLE; BODY WEIGHT; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; DYSPNEA; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART STROKE VOLUME; HEMOGLOBIN BLOOD LEVEL; HUMAN; LEG EDEMA; MALE; MERIDIONAL END SYSTOLIC STRESS; MITRAL DECELERATION INDEX; MITRAL VALVE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SWELLING; SYSTOLE; SYSTOLIC BLOOD PRESSURE; TISSUE DOPPLER IMAGING; UNSPECIFIED SIDE EFFECT; VASCULAR RESISTANCE; WAIST HIP RATIO; WEIGHT GAIN;

DIABETES; DIASTOLIC FUNCTION; LEFT VENTRICLE; THIAZOLIDINEDIONES;

AGED; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; THIAZOLIDINEDIONES; VENTRICULAR FUNCTION, LEFT;

EID: 84881475084     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.03.179     Document Type: Article

References (44)

1. D.M. Nathan, J.B. Buse, and M.B. Davidson Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes Diabetes Care 32 2009 193 203
2. R.A. DeFronzo, D. Tripathy, and D.C. Schwenke Pioglitazone for diabetes prevention in impaired glucose tolerance N Engl J Med 364 2011 1104 1115
3. S. Singh, Y.K. Loke, and C.D. Furberg Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis JAMA 298 2007 1189 1195
4. A.M. Lincoff, K. Wolski, S.J. Nicholls, and S.E. Nissen Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials JAMA 298 2007 1180 1188
5. W.B. Kannel, and D.L. McGee Diabetes and cardiovascular disease. The Framingham study JAMA 241 1979 2035 2038
6. S. Boudina, and E.D. Abel Diabetic cardiomyopathy revisited Circulation 115 2007 3213 3223
7. J.K. Boyer, S. Thanigaraj, K.B. Schechtman, and J.E. Perez Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus Am J Cardiol 93 2004 870 875
8. A.M. From, C.G. Scott, and H.H. Chen Changes in diastolic dysfunction in diabetes mellitus over time Am J Cardiol 103 2009 1463 1466
9. T. Horio, M. Suzuki, and K. Suzuki Pioglitazone improves left ventricular diastolic function in patients with essential hypertension Am J Hypertens 18 2005 949 957
10. S. Pala, O. Esen, and M. Akcakoyun Rosiglitazone, but not pioglitazone, improves myocardial systolic function in type 2 diabetic patients: a tissue Doppler study Echocardiography 27 2010 512 518
11. Kemal Turkmen, Kemal Y. Turkmen, and Guvener Effects of rosiglitazone on plasma brain natriuretic peptide levels and myocardial performance index in patients with type 2 diabetes mellitus Acta Diabetol 44 2007 149 156
12. M.N. Ghazzi, J.E. Perez, and T.K. Antonucci Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group Diabetes 46 1997 433 439
13. H.J. Dargie, P.R. Hildebrandt, and G.A. Riegger A randomized, placebo-controlled trial assessing the effects of rosiglitazone on echocardiographic function and cardiac status in type 2 diabetic patients with New York Heart Association Functional Class I or II Heart Failure J Am Coll Cardiol 49 2007 1696 1704
14. M. St John Sutton, M. Rendell, and P. Dandona A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetes Diabetes Care 25 2002 2058 2064
15. R.W. van der Meer, L.J. Rijzewijk, and H.W. de Jong Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus Circulation 119 2009 2069 2077
16. R.M. Lago, P.P. Singh, and R.W. Nesto Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials Lancet 370 2007 1129 1136
17. H.D. Berlie, J.S. Kalus, and L.A. Jaber Thiazolidinediones and the risk of edema: a meta-analysis Diabetes Res Clin Pract 76 2007 279 289
18. Erland Erdmann, and RobertG. Wilcox Weighing up the cardiovascular benefits of thiazolidinedione therapy: the impact of increased risk of heart failure Eur Heart J 29 2008 12 20
19. R.M. Lang, M. Bierig, and R.B. Devereux Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology J Am Soc Echocardiogr 18 2005 1440 1463
20. W. Grossman, E. Braunwald, T. Mann, L.P. McLaurin, and L.H. Green Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations Circulation 56 1977 845 852
21. G. de Simone, R.B. Devereux, M.J. Koren, G.A. Mensah, P.N. Casale, and J.H. Laragh Midwall left ventricular mechanics. An independent predictor of cardiovascular risk in arterial hypertension Circulation 93 1996 259 265
22. R.K. Mishra, J.M. Galloway, and E.T. Lee The ratio of mitral deceleration time to E-wave velocity and mitral deceleration slope outperform deceleration time alone in predicting cardiovascular outcomes: the Strong Heart Study J Am Soc Echocardiogr 20 2007 1300 1306
23. D.W. Sohn, I.H. Chai, and D.J. Lee Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function J Am Coll Cardiol 30 1997 474 480
24. H. Hasegawa, W.C. Little, and M. Ohno Diastolic mitral annular velocity during the development of heart failure J Am Coll Cardiol 41 2003 1590 1597
25. M. Wang, G.W. Yip, and A.Y. Wang Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value J Am Coll Cardiol 41 2003 820 826
26. D. Vinereanu, E. Nicolaides, and A.C. Tweddel Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and glycated haemoglobin Clin Sci (Lond) 105 2003 591 599
27. A. Sharp, R. Tapp, and D.P. Francis Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy J Am Coll Cardiol 52 2008 1015 1021
28. S. Senn Cross-over trials in clinical research 2002
29. G.M. Fitzmaurice, and C. Ravichandran A primer in longitudinal data analysis Circulation 118 2008 2005 2010
30. M. Iglarz, R.M. Touyz, and E.C. Viel Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension Hypertension 42 2003 737 743
31. S. Nemoto, P. Razeghi, M. Ishiyama, G. De Freitas, H. Taegtmeyer, and B.A. Carabello PPAR-gamma agonist rosiglitazone ameliorates ventricular dysfunction in experimental chronic mitral regurgitation Am J Physiol Heart Circ 288 2005 H77 H82
32. Y.T. Zhou, P. Grayburn, and A. Karim Lipotoxic heart disease in obese rats: implications for human obesity Proc Natl Acad Sci U S A 97 2000 1784 1789
33. R. Lautamaki, K.E. Airaksinen, and M. Seppanen Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study Diabetes 54 2005 2787 2794
34. 1H-magnetic resonance spectroscopy study Circulation 116 2007 1170 1175
35. I. Zib, A.N. Jacob, and I. Lingvay Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes J Investig Med 55 2007 230 236
36. J. Hetzel, B. Balletshofer, and K. Rittig Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers Arterioscler Thromb Vasc Biol 25 2005 1804 1809
37. F.A. Masoudi, S.E. Inzucchi, Y. Wang, E.P. Havranek, J.M. Foody, and H.M. Krumholz Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study Circulation 111 2005 583 590
38. J.A. Dormandy, B. Charbonnel, and D.J. Eckland Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial Lancet 366 2005 1279 1289
39. D.J. Betteridge, R.A. DeFronzo, and R.J. Chilton PROactive: time for a critical appraisal Eur Heart J 29 2008 969 983
40. S. Shadid, and M.D. Jensen Effects of pioglitazone versus diet and exercise on metabolic health and fat distribution in upper body obesity Diabetes Care 26 2003 3148 3152
41. R. Berria, L. Glass, and A. Mahankali Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in type II diabetes mellitus Clin Pharmacol Ther 82 2007 275 281
42. S.R. Smith, L. de Jonge, J. Volaufova, Y. Li, H. Xie, and G.A. Bray Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trial Metabolism 54 2005 24 32
43. A. Basu, M.D. Jensen, F. McCann, D. Mukhopadhyay, M.J. Joyner, and R.A. Rizza Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes Diabetes Care 29 2006 510 514
44. M. Wang, G.W. Yip, and C.M. Yu Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function J Am Coll Cardiol 45 2005 272 277