Fluidless resuscitation with permissive hypotension via impedance threshold device therapy compared with normal saline resuscitation in a porcine model of severe hemorrhage

Journal of Trauma and Acute Care Surgery

Volumn 75, Issue 2 SUPPL. 2, 2013, Pages

  Metzger, Anja ^a,b   Rees, Jennifer ^a   Segal, Nicolas ^b   McKnite, Scott ^c   Matsuura, Timothy ^b   Convertino, Victor A ^d   Gerhardt, Robert T ^d,e,f   Lurie, Keith G ^a,b,c  

^a Advanced Circulatory Systems Inc   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

^d US Army Institute of Surgical Research   (United States)

^e SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^f Uniformed Services University of the Health Sciences   (United States)

Author keywords

baroreflex sensitivity; cardiac vagal withdrawal; lower body negative pressure; Shock index; vital signs

Indexed keywords

SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BRAIN PERFUSION; BREATHING RATE; CONTROLLED STUDY; DEVICE THERAPY; DISEASE SEVERITY; FEMALE; FLUID RESUSCITATION; HEART HEMODYNAMICS; HEMATOCRIT; HEMODILUTION; HYPOTENSION; IMPEDANCE THRESHOLD DEVICE THERAPY; NEGATIVE INTRATHORACIC PRESSURE; NONHUMAN; PERMISSIVE HYPOTENSION; PRIORITY JOURNAL; PULSE PRESSURE; RESUSCITATION; SYSTOLIC BLOOD PRESSURE; THORAX PRESSURE;

ANIMALS; BLOOD PRESSURE; CARDIOPULMONARY RESUSCITATION; DISEASE MODELS, ANIMAL; FEMALE; FLUID THERAPY; HYPOTENSION; SHOCK, HEMORRHAGIC; SODIUM CHLORIDE; SWINE;

EID: 84881442085     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318299d5d0     Document Type: Article

References (24)

1. Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105-1109.
2. Rhee P, Koustova E, Alam HB. Searching for the optimal resuscitation method: recommendations for the initial fluid resuscitation of combat casualties. J Trauma. 2003;54(suppl 5):S52-S62
3. Geeraedts LM Jr, Kaasjager HA, van Vugt AB, Frolke JP. Exsanguination in trauma: a review of diagnostics and treatment options. Injury. 2009; 40:11-20.
4. Kreimeier U, Prueckner S, Peter K. Permissive hypotensio3. Schweiz Med Wochenschr. 2000;130:1516-1524.
5. Kowalenko T, Stern S, Dronen S, Wang X. Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock in a swine model. J Trauma. 1992;33:349-353; discussion 361-342.
6. Sondeen JL, Coppes VG, Holcomb JB. Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury. J Trauma. 2003; 54(suppl 5):S110YS117
7. Sondeen JL, Dubick MA, Holcomb JB, Wade CE. Uncontrolled hemorrhage differs from volume- or pressure-matched controlled hemorrhage in swine. Shock. 2007;28:426-433.
8. Morrison CA, Carrick MM, Norman MA, et al. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial. J Trauma. 2011;70:652-663.
9. Lurie KG, Zielinski TM, McKnite SH, et al. Treatment of hypotension in pigs with an inspiratory impedance threshold device: a feasibility study. Crit Care Med. 2004;32:1555-1562.
10. Convertino VA, Cooke WH, Lurie KG. Inspiratory resistance as a potential treatment for orthostatic intolerance and hemorrhagic shock. Aviat Space Environ Med. 2005;76:319-325.
11. Convertino VA, Ratliff DA, Eisenhower KC, et al. Inspiratory impedance effects on hemodynamic responses to orthostasis in ormal subjects. Aviat Space Environ Med. 2006;77:486-493.
12. Convertino VA, Ratliff DA, Ryan KL, et al. Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers. Crit Care Med. 2004;32(suppl 9):S381-S386
13. Convertino VA, Ryan KL, Rickards CA, et al. Inspiratory resistance maintains arterial pressure during central hypovolemia: implications for treatment of patients with severe hemorrhage. Crit Care Med. 2007;35:1145-1152.
14. Convertino VA, Ryan KL, Rickards CA, et al. Optimizing the respiratory pump: harnessing inspiratory resistance to treat hypotensio3. Resp Care. 2011;56:846-857.
15. Lurie KG, Coffeen P, Shultz J, McKnite S, Detloff B, Mulligan K. Improving active compression-decompression cardiopulmonary resuscitation with an inspiratory impedance valve. Circulatio3. 1995;91:1629-1632.
16. Lurie K, Zielinski T, McKnite S. Use of an inspiratory impedance threshold valve for rapid treatment of cardiovascular collapse secondary to heat shock in spontaneously breathing pigs. Crit Care Med. 2002;29:A49
17. Marino BS, Yannopoulos D, Sigurdsson G, et al. Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic hypovolemia. Crit Care Med. 2004;32(suppl 9):S398-S405
18. Convertino VA, Parquette B, Meiher J, et al. Use of respiratory impedance in pre-hospital care of hypotensive patients associated with hemorrhage and trauma: a case series. J Trauma Acute Care Surg. 2012;73:S65-S59
19. Bickell WH, Barrett SM, Romine-Jenkins M, Hull SS Jr, Kinasewitz GT. Resuscitation of canine hemorrhagic hypotension with large-volume isotonic crystalloid: impact on lung water, venous admixture, and systemic arterial oxygen saturatio3. Am J Emerg Med. 1994;12:36-42.
20. Sigurdsson G, Yannopoulos D, McKnite SH, Sondeen JL, Benditt DG, Lurie KG. Effects of an inspiratory impedance threshold device on blood pressure and short term survival in spontaneously breathing hypovolemic pigs. Resuscitatio3. 2006;68:399-404.
21. YannopoulosD, McKnite SH, Metzger A, Lurie KG. Intrathoracic pressure regulation for intracranial pressure management in ormovolemic and hypovolemic pigs. Crit Care Med. 2006;34(suppl 12):S495-S500.
22. Smith WR, Moore EE, Osborn P, et al. Retroperitoneal packing as a resuscitation technique for hemodynamically unstable patients with pelvic fractures: report of two representative cases and a description of technique. J Trauma. 2005;59:1510-1514.
23. Madigan MC, Kemp CD, Johnson JC, Cotton BA. Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame? J Trauma. 2008; 64:280-285.
24. Metzger A, Marino B, Matsuura T, et al. An Impedance threshold device improves 24 hour survival in a spontaneously breathing pediatric porcine model of hemorrhagic shock. Circulatio3. 2007;116:632