Treatment of knee osteochondritis dissecans with a cell-free biomimetic osteochondral scaffold: Clinical and imaging evaluation at 2-year follow-up

American Journal of Sports Medicine

Volumn 41, Issue 8, 2013, Pages 1786-1793

  Filardo, Giuseppe ^a   Kon, Elizaveta ^a   Di Martino, Alessandro ^a   Busacca, Maurizio ^a   Altadonna, Giulio ^a   Marcacci, Maurilio ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

biomimetic scaffold; knee; OCD; osteochondral regeneration; osteochondritis dissecans

Indexed keywords

BIOMIMETIC MATERIAL; COLLAGEN TYPE 1; HYDROXYAPATITE; NANOMATERIAL; TISSUE SCAFFOLD;

ADULT; ARTICLE; BIOMIMETIC SCAFFOLD; CLINICAL TRIAL; CONVALESCENCE; EQUIPMENT; FEMALE; FOLLOW UP; HUMAN; KNEE; MALE; METHODOLOGY; OCD; OSTEOCHONDRAL REGENERATION; OSTEOCHONDRITIS DISSECANS; PHYSIOLOGY; PROSPECTIVE STUDY; TISSUE REGENERATION; TREATMENT OUTCOME;

BIOMIMETIC SCAFFOLD; KNEE; OCD; OSTEOCHONDRAL REGENERATION; OSTEOCHONDRITIS DISSECANS;

ADULT; BIOMIMETIC MATERIALS; COLLAGEN TYPE I; DURAPATITE; FEMALE; FOLLOW-UP STUDIES; GUIDED TISSUE REGENERATION; HUMANS; KNEE JOINT; MALE; NANOSTRUCTURES; OSTEOCHONDRITIS DISSECANS; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; TISSUE SCAFFOLDS; TREATMENT OUTCOME;

EID: 84881437395     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513490658     Document Type: Article

References (46)

1. Bartlett W, Gooding CR, Carrington RW, Skinner JA, Briggs TW, Bentley G. Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft: a preliminary report. J Bone Joint Surg Br. 2005 ; 87: 330-332
2. Brittberg M, Winalski CS. Evaluation of cartilage injuries and repair. J Bone Joint Surg Am. 2003 ; 85: 58-69
3. Buma P, Pieper JS, van Tienen T, et al. Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects - a study in rabbits. Biomaterials. 2003 ; 24 (19). 3255-3263
4. Cahill BR, Phillips MR, Navarro R. The results of conservative management of juvenile osteochondritis dissecans using joint scintigraphy: a prospective study. Am J Sports Med. 1989 ; 17: 601-605
5. Chambers HG, Shea KG, Anderson AF, et al. American Academy of Orthopaedic Surgeons clinical practice guideline on the diagnosis and treatment of osteochondritis dissecans. J Bone Joint Surg Am. 2012 ; 94 (14). 1322-1324
6. Cole BJ, DeBerardino T, Brewster R, et al. Outcomes of autologous chondrocyte implantation in study of the treatment of articular repair (STAR) patients with osteochondritis dissecans. Am J Sports Med. 2012 ; 40 (9). 2015-2022
7. Detterline AJ, Goldstein JL, Rue JP, Bach BR. Evaluation and treatment of osteochondritis dissecans lesions of the knee. J Knee Surg. 2008 ; 21 (2). 106-115
8. De Smet AA, Ilahi OA, Graf BK. Untreated osteochondritis dissecans of the femoral condyles: prediction of patient outcome using radiographic and MR findings. Skeletal Radiol. 1997 ; 26 (8). 463-467
9. Filardo G, Di Martino A, Kon E, Delcogliano M, Marcacci M. Midterm results of a combined biological and mechanical approach for the treatment of a complex knee lesion. Cartilage. 2012 ; 3: 288-292
10. Filardo G, Kon E, Berruto M, et al. Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: results at 6 years. Knee. 2012 ; 19 (5). 658-663
11. Filardo G, Kon E, Di Martino A, Iacono F, Marcacci M. Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study. Am J Sports Med. 2011 ; 39 (10). 2153-2160
12. Filardo G, Kon E, Roffi A, Di Martino A, Marcacci M. Scaffold-based repair for cartilage healing: a systematic review and technical note. Arthroscopy. 2013 ; 29 (1). 174-186
13. Gomoll AH, Probst C, Farr J, Cole BJ, Minas T. Use of a type I/III bilayer collagen membrane decreases reoperation rates for symptomatic hypertrophy after autologous chondrocyte implantation. Am J Sports Med. 2009 ; 37: 20S - 23S
14. Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A. A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III collagen covered. Knee. 2006 ; 13 (3). 203-210
15. ICRS Cartilage Injury Evaluation Package, 2000. http://www.cartilage.org/ -files/contentmanagement/ICRS-evaluation.pdf.
16. Kocher MS, Tucker R, Ganley TJ, Flynn JM. Management of osteochondritis dissecans of the knee: current concepts review. Am J Sports Med. 2006 ; 34 (7). 1181-1191
17. Kon E, Delcogliano M, Filardo G, et al. A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: technique note and an early stability pilot clinical trial. Injury. 2010 ; 41 (7). 693-701
18. Kon E, Delcogliano M, Filardo G, Altadonna G, Marcacci M. Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2009 ; 17 (11). 1312-1315
19. Kon E, Delcogliano M, Filardo G, et al. Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial. J Orthop Res. 2010 ; 28 (1). 116-124
20. Kon E, Delcogliano M, Filardo G, Busacca M, Di Martino A, Marcacci M. Novel nano-composite multilayered biomaterial for osteochondral regeneration: a pilot clinical trial. Am J Sports Med. 2011 ; 39 (6). 1180-1190
21. Kon E, Filardo G, Delcogliano M, et al. Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model. BMC Musculoskelet Disord. 2010 ; 11: 220
22. Kon E, Filardo G, Di Martino A, Marcacci M. ACI and MACI. J Knee Surg. 2012 ; 25 (1). 17-22
23. Kon E, Gobbi A, Filardo G, Delcogliano M, Zaffagnini S, Marcacci M. Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years. Am J Sports Med. 2009 ; 37 (1). 33-41
24. Kon E, Muttini A, Arcangeli E, et al. Novel nanostructured scaffold for osteochondral regeneration: pilot study in horses. J Tissue Eng Regen Med. 2010 ; 4 (4). 300-308
25. Kon E, Vannini F, Buda R, et al. How to treat osteochondritis dissecans of the knee: surgical techniques and new trends: AAOS exhibit selection. J Bone Joint Surg Am. 2012 ; 94 (1). 1-8
26. Kon E, Verdonk P, Condello V, et al. Matrix-assisted autologous chondrocyte transplantation for the repair of cartilage defects of the knee: systematic clinical data review and study quality analysis. Am J Sports Med. 2009 ; 37: 156S - 166S
27. Kramer J, Böhrnsen F, Lindner U, et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci. 2006 ; 63: 616-626
28. Krishnan SP, Skinner JA, Carrington RW, Flanagan AM, Briggs TW, Bentley G. Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee: two- to seven-year results. J Bone Joint Surg Br. 2006 ; 88: 203-205
29. Lim HC, Bae JH, Park YE, et al. Long-term results of arthroscopic excision of unstable osteochondral lesions of the lateral femoral condyle. J Bone Joint Surg Br. 2012 ; 94 (2). 185-189
30. Linden B. The incidence of osteochondritis dissecans in the condyles of the femur. Acta Orthop Scand. 1976 ; 47: 666-667
31. Marlovits S, Singer P, Zeller P, et al. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol. 2006 ; 57 (1). 16-23
32. Marlovits S, Striessnig G, Resinger CT, et al. Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol. 2004 ; 52: 310-319
33. Maus U, Schneider U, Gravius S, et al. Clinical results after three years use of matrix-associated ACT for the treatment of osteochondral defects of the knee. Z Orthop Unfall. 2008 ; 146 (1). 31-37
34. Moriya T, Wada Y, Watanabe A, et al. Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. J Orthop Sci. 2007 ; 12: 265-273
35. Ochs BG, Müller-Horvat C, Rolauffs B, Fritz J, Weise K, Schewe B. Treatment of osteochondritis dissecans of the knee: one-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation. Z Orthop Unfall. 2007 ; 145 (2). 146-151
36. Pape D, Filardo G, Kon E, van Dijk CN, Madry H. Disease-specific clinical problems associated with the subchondral bone. Knee Surg Sports Traumatol Arthrosc. 2010 ; 18 (4). 448-462
37. Peterson L, Minas T, Brittberg M, Lindahl A. Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am. 2003 ; 85: 17-24
38. Peterson L, Vasiliadis HS, Brittberg M, Lindahl A. Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med. 2010 ; 38 (6). 1117-1124
39. Shirazi R, Shirazi-Adl A. Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects. J Biomech. 2009 ; 42: 2458-2465
40. Steinhagen J, Bruns J, Deuretzbacher G, Ruether W, Fuerst M, Niggemeyer O. Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes. Int Orthop. 2010 ; 34 (6). 819-825
41. Stone KR, Walgenbach AW, Freyer A, Turek TJ, Speer DP. Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up. Arthroscopy. 2006 ; 22 (3). 291-299
42. Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop. 1985 ; 198: 43-49
43. Teo BJ, Buhary K, Tai BC, Hui JH. Cell-based therapy improves function in adolescents and young adults with patellar osteochondritis dissecans. Clin Orthop Relat Res. 2013 ; 471 (4). 1152-1158
44. Trinh TQ, Harris JD, Flanigan DC. Surgical management of juvenile osteochondritis dissecans of the knee. Knee Surg Sports Traumatol Arthrosc. 2012 ; 20 (12). 2419-2429
45. Vasiliadis HS, Danielson B, Ljungberg M, McKeon B, Lindahl A, Peterson L. Autologous chondrocyte implantation in cartilage lesions of the knee: long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique. Am J Sports Med. 2010 ; 38 (5). 943-949
46. Vijayan S, Bartlett W, Bentley G, et al. Autologous chondrocyte implantation for osteochondral lesions in the knee using a bilayer collagen membrane and bone graft: a two- to eight-year follow-up study. J Bone Joint Surg Br. 2012 ; 94 (4). 488-492