Controlled formulation for epinephrine delivery from hydrogel microspheres

Tissue Engineering and Regenerative Medicine

Volumn 6, Issue 1-3, 2009, Pages 119-125

  Minh, Ta Tuan ^a   Baek, Woon Yi ^a   Lim, Jeong Ok ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Alginate; Epinephrine; Microspheres; Release kinetics

Indexed keywords

COATING MATERIAL; CONTROLLED DELIVERY; CROSS LINKING AGENTS; EPINEPHRINE; HYDROGEL MICROSPHERES; LOADING EFFICIENCY; LOCAL ANESTHETICS; RELEASE KINETICS;

ALGINATE; BLOOD VESSELS; RATS;

MICROSPHERES;

EID: 84881393661     PISSN: 17382696     EISSN: 22125469     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. K Ercan, C Hakan, Y Tukan, et al, Effect of long- term application of epinephrine on rat skin vasculature: experimental study, Microsurgery, 22, 288 (2002).
2. B John, Epinephrine containing anesthetic safe for patient, About, Health Fitness, Dentistry, 5, 9 (2002).
3. R Miller, Factors influencing anesthetic activity in humans, Anesthesia, Fourth ed, 1, Chap 13. Local anesthetics, 503 (2001).
4. C Shih, T Higuchi, KJ Himmelstein, Drug release from catalysed erodible polymeric matrices of poly(othorester)s, Biomaterials, 5, 237 (1984).
5. R Wayne, Gombotz, FW Siow, Protein release from alginate matrices, Adv Drug Deliv Rev, 31, 267 (1998).
6. K Ercan, C Hakan, Y Tukan, et al, Chemical delay: An alternative to surgical delay experimental study, Ann Plast Surg, 49, 73 (2002).
7. B Arica, S Calis, HS Kas, et al, 5-fluorouracil encapsulated alginate beads for the treatment of breast cancer, Inter J Pharm, 242, 267 (2002).
8. R David, Bicinchoninic acid(BCA) protein assay(Smith), Rice Unive J, 16, 8 (1996).
9. J Curley, J Castillo, J Hotz, et al, Prolonged regional nerve blockade, Anesthesiology, 84, 1401 (1996).
10. JG Thalhammer, M Vladimirova, B Bershadsky, et al, Neurological evaluation of the rat during sciatic nerve block with lidocaine, Anesthesiology, 82, 1013 (1995).
11. Y Dai, K Iwata, E Kondo, et al, A selective increase in Fos expression in spinal dorsal horn neurons following graded thermal stimulation in rats with experimental mononeuropathy, Pain, 90, 287 (2001).
12. J Cui, J Goh, S Park, et al, Preparation and physical characterization of alginate microparticle using air atomization method, Drug Dev Ind Pharm, 27(4), 309 (2001).
13. L Lin-Shu, L Shu Qui, YN Steven, et al, Controlled release of interleukin 2 for tumour immunotherapy using alginate/chitosan porous microspheres, J Controlled Release, 43, 65 (1997).
14. A Blandino, M Macias, D Cantero, Formation of calcium alginate gel capsules: influence of sodium alginate and CaCl2 concentration on gelation kinetics, J Biosci Bioeng, 88(6), 686 (1999).
15. B Thu, P Bruheim, T Espevik, et al, Alginate polycation microcapsules, Biomaterials, 17, 1031 (1996).
16. G Klock, A Pfeffermann, C Ryser, et al, Biocompatibility of mannuronic acid rich alginates, Biomaterials, 18, 707 (1997).
17. D Lemoine, F Wauter, S Bouchend'home, et al, Preparation and characterization of alginate microspheres containing a model antigen, Int J Pharm, 176, 9 (1998).
18. RS Hermes, R Narayani, Polymeric alginate films and alginate beads for the controlled delivery of macromolecules, Trends Biomater Artif Organs, 15 (2), 54 (2002).
19. G Khang, MS Kim, SH Cho, et al, Natural scaffolds biomaterials for tissue regeneration, Tissue Eng Regen Med, 1(1), 9 (2004).
20. GH Choi, YH Youn, DY Kim, et al, Alginate gel decreases chondroitin sulfate proteoglycan immunoreactivity following spinal cord injury: preliminary study, Tissue Eng Regen Med, 3(4), 472 (2006).
21. JS Hwang, KY Yuk, KM Huh, Research and development of superporous hydrogels with fast swelling and superabsorbent properties, Tissue Eng Regen Med, 5(2), 147 (2008).
22. J Ku, JH Park, SI Ahn, et al, Effect of the concentration of sodium alginate on the BSA release from BSA/PLGA microspheres, Tissue Eng Regen Med, 5(4∼6), 723 (2008).