In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5323-5331

  Jing, Qing ^a   Li, Huiying ^b   Fang, Jianguo ^a   Roman, Linda J ^c   Martásek, Pavel ^d   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Aminopyridines; Inhibition; Neuronal nitric oxide synthase; Nitric oxide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; IC 50; MACROPHAGE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

AMINOPYRIDINES; INHIBITION; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

AMINOPYRIDINES; BENZYLAMINES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; ENZYME INHIBITORS; MOLECULAR DOCKING SIMULATION; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN BINDING; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881376107     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.014     Document Type: Article

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