PMA increases M3 muscarinic receptor levels and decreases retinal cells proliferation through a change in the levels of cell-cycle regulatory proteins

Neuroscience Letters

Volumn 550, Issue , 2013, Pages 29-34

  Braga, Luis Eduardo Gomes ^a   Granja, Marcelo Gomes ^a   da Silva, Gustavo Mataruna ^a   Giestal de Araujo, Elizabeth ^a   dos Santos, Aline Araujo ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Cyclin D1; P21; P53; PKC; Rat

Indexed keywords

CYCLIN D1; MUSCARINIC M3 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA CELL; TISSUE DIFFERENTIATION;

CYCLIN D1; P21; P53; PKC; RAT;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; PHORBOL ESTERS; RATS; RECEPTOR, MUSCARINIC M3; RETINAL NEURONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84881373309     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.06.045     Document Type: Article

References (42)

1. Abbas T., White D., Hui L., Yoshida K., Foster D.A., Bargonetti J. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cδ. J. Biol. Chem. 2004, 279:9970-9977.
2. Abreu-Villaça Y., Filgueira C.C., Manhães A.C. Developmental aspects of the cholinergic system. Behav. Brain Res. 2011, 221:367-378.
3. Afrasiabi E., Ahlgren J., Bergelin N., Tornquist K. Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCδ. Mol. Cell Endocrinol. 2008, 292:26-35.
4. Alexiades M.R., Cepko C. Quantitative analysis of proliferation cell cycle length during development of the rat retina. Dev. Dyn. 1996, 205:293-307.
5. Arber N., Doki Y., Han E.K.-H., Sgambato A., Zhou P., Kim N.-H., Delohery T., Klein M.G., Holt P.R., Weinstein I.B. Antisense to cyclin Dl inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res. 1997, 57:1569-1574.
6. Baudier J., Delphin C., Grunwald D., Khochbin S., Lawrence J.J. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:11627-11631.
7. Coutinho I., Pereira G., Leão M., Gonçalves J., CÔrte-Real M., Saraiva L. Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system. FEBS Lett. 2009, 583:3582-3588.
8. De Angelis F., Bernardo A., Magnaghi V., Minguetti L., Tata A.M. Muscarinic receptor subtypes as potential targetsto modulate oligodendrocyte progenitor survival, proliferation, and differentiation. Dev. Neurobiol. 2012, 72:713-728. 10.1002/dneu.20976.
9. Frey M.R., Clark J.A., Leontieva O., Uronis J.M., Black A.R., Black J.D. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium. J. Cell Biol. 2000, 151:763-777.
10. Garcia S.C., Fernandez J.C.G. Protein cinase C regulatory domains: the art of decoding many different signals in membranes. Biochim. Biophys. Acta 2006, 1761:633-654.
11. Gévry N., Chan H.M., Laflamme L., Livingston D.M., Gaudreau L. p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev. 2007, 1869:1881.
12. Giorgi C., Agnoletto C., Baldini C., Bononi A., Bonora M., Marchi S., Missiroli S., Patergnani S., Poletti F., Rimessi A., Zavan B., Pinton P. Redox control of protein kinase C: cell- and disease-specific aspects. Antioxid. Redox Signal. 2010, 13:1051-1085.
13. Guizzetti M., Moore N.H., Vandemark K.L., Giordano G., Costa L.G. Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons. Eur. J. Pharmacol. 2011, 659:102-107.
14. He G., Siddik Z.H., Huang Z., Wang R., Koomen J., Kobayashi R., Khokar A.R., Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 2005, 24:2929-2943.
15. Hupp T.R., Meek D.W., Midgley C.A., Lane D.P. Regulation of the specific DNA binding function of p53. Cell 1992, 71:875-886.
16. Iannazzo L., Kotsonis P., Majewski H. Modulation of acetylcholine release from mouse cortex by dependence on stimulation intensity. Life Sci. 2000, 67:31-38.
17. Kim Y.R., Byun H.S., Jeon J., Choi B.L., Park K.A., Won M., Zhang T., Shin S., Lee H., Oh J., Hur G.M. Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation. Cell Biochem. Biophys. 2011, 61:199-207.
18. Lanzafame A.A., Christopoulos A., Mitchelson F. Cellular signaling mechanisms for muscarinic acetylcholine receptors. Receptors Channels 2003, 9:241-260.
19. Martins R.A.P., Pearson R.A. Control of cell proliferation by neurotransmitters in the developing vertebrate retina. Brain Res. 2008, 1192:37-60.
20. McKinnon L.A., Rosoff M., Hamilton S.E., Schlador M.L., Thomas S.L., Nathanson N.M. Regulation of muscarinic receptor expression and function in culture cells and knock-out mice. Life Sci. 1997, 60:1101-1104.
21. Meng L-H., Zhang H., Haywardl L., Talemura H., Shao R.G., Pommier Y. Tetandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. Cancer Res. 2004, 64:9086-9092.
22. Nakagawa M., Oliva J.L., Kothapalli D., Fournier A., Assoian R.K., Kazanietz M.G. Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cδ-dependent induction of p21. J. Biol. Chem. 2005, 280:33926-33934.
23. 2-treated bovine endothelial cells. Free Radic. Res. 2002, 36:1147-1153.
24. Park J.W., Jang M.A., Lee Y.H., Passaniti A., Kwon T.K. p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization. Biochem. Biophys. Res. Commun. 2001, 280:244-248.
25. Pospisilová S., Brázda V., Kucharíková K., Luciani M.G., Hupp T.R., Skaládal P., Palecek E., Vojtesek B. Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2. Biochem. J. 2004, 378:939-947.
26. Ragheb F., Molina-Holgado E., Cui Q.L., Khorchid A., Liu H.N., Larocca J.N., Almazan G. Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes. J. Neurochem. 2001, 77:1396-1406.
27. Reyland M.E. Protein kinase C isoforms: multi-functional regulators of cell life and death. Front. Biosci. 2009, 14:2386-2399.
28. Santos A.A., Araujo E.G. The effect of PKC activation on survival of rat retinal ganglion cells in culture. Brain Res. 2000, 853:338-343.
29. Santos A.A., Medina S.V., Sholl-Franco A., Araujo E.G. PMA decreases the proliferation of retinal cells in vitro: the involvement of acetylcholine and BDNF. Neurochem. Int. 2003, 42:73-80.
30. Santos A.A., Medina S.V., Martins L.A., Araujo E.G. Protein kinase C regulates the expression of M1 receptors and BDNF in rat retinal cells. Neurochem. Res. 2009, 34:884-890.
31. Schiliebs R., Arendt T. The cholinergic system in aging and neuronal degeneration. Behav. Brain Res. 2011, 221:555-563.
32. Sipeki S., Bander E., Ways D.K., Faragó A. Activation of Erk1/Erk2 and transiently increased p53 levels together may account for p21 expression associated with phorbol ester-induced transient growth inhibition in HepG2 cells. Cell Signal. 2002, 14:115-121.
33. Tahara E., Kadara H., Lacroix L., Lotan F., Lotan R. Activation of protein kinase C by phorbol 12-myristate 13-acetate supresses the growth of lung cancer cells through KLF6 induction. Cancer Biol. Ther. 2009, 8:801-807.
34. Tarn W.Y., Lai M.C. Translational control of cyclins. Cell Div. 2011, 6:5.
35. Tashiro E., Tsuchiya A., Imoto M. Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci. 2007, 98:629-635.
36. Traore K., Trush M.A., George M., Spannhake E.W., Anderson W., Asseffa A. Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent. Leuk. Res. 2005, 29:863-879.
37. Ullrich S.J., Anderson C.H., Mercer W.E., Apella E. The p53 tumor suppressor protein, a modulator of cell proliferation. J. Biol. Chem. 1992, 267:15259-15262.
38. Vaughan P.F.T., Walker J.H., Peers C. The regulation of neurotransmitter secretion by protein kinase C. Mol. Neurobiol. 1998, 18:125-148.
39. Weidman T.A., Kuwabara T. Development of the rat retina. Invest. Ophthalmol. 1969, 8:60-69.
40. Wood J.P.M., McCord R.J., Osborne N.N. Retinal protein kinase C. Neurochem. Int. 1997, 30:119-136.
41. Wu H.M., Schally A.V., Cheng J.C., Zarandi M., Varga J., Leung P. Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCδ-mediated activation of p53/p21. Cancer Lett. 2010, 298:16-25.
42. Yang K., Hitomi M., Stacey D.W. Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell. Cell Div. 2006, 1:32.