Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: Evidence for an effect mediated by PKCδ

Molecular and Cellular Endocrinology

Volumn 292, Issue 1-2, 2008, Pages 26-35

  Afrasiabi, Emad ^a   Ahlgren, Janiina ^a   Bergelin, Nina ^a,b   Törnquist, Kid ^a,c  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

Cancer; Cell cycle; Phorbol esters; Protein kinase C; Thyroid

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 AMINOETHOXYDIPHENYL BORANE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLLEUCYLLEUCYLLMETHIONINAL; ACETYLLEUCYLLEUCYLNORLEUCINAL; CALCIUM CHANNEL BLOCKING AGENT; CALPASTATIN; CALPHOSTIN C; CYCLIN DEPENDENT KINASE INHIBITOR 1; DIOCTANOIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; ROTTLERIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXO;

ANAPLASTIC CARCINOMA; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THYROID CANCER; UPREGULATION;

CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FORKHEAD TRANSCRIPTION FACTORS; G1 PHASE; HUMANS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASES; PHORBOLS; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; S PHASE; TETRADECANOYLPHORBOL ACETATE; THYROID NEOPLASMS; TRANSFECTION;

EID: 49549097606     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.04.018     Document Type: Article

References (42)

1. Afrasiabi E., Blom T., Ekokoski E., Tuominen R.K., and Tornquist K. Sphingosyl-phosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. Cell. Signal. 18 (2006) 1671-1678
2. Afrasiabi E., Blom T., Balthasar S., and Törnquist K. Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase. Mol. Cell. Endocrinol. 274 (2007) 43-52
3. Arden K.C. Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp. Gerontol. l41 (2006) 709-717
4. Blumberg P.M., Delclos K.B., Dunn J.A., Jaken S., Leach K.L., and Yeh E. Phorbol ester receptors and the in vitro effects of tumor promoters. Ann. NY Acad. Sci. 407 (1983) 303-315
5. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., and Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96 (1999) 857-868
6. Clark J.A., Black A.R., Leontieva O.V., Frey M.R., Pysz M.A., Kunneva L., Woloszynska-Read A., Roy D., and Black J.D. Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells. J. Biol. Chem. 279 (2004) 9233-9247
7. Cerda S.R., Mustafi R., Little H., Cohen G., Khare S., Moore C., Majumder P., and Bissonnette M. Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. Oncogene 25 (2006) 3123-3138
8. Chen C.L., Hsieh Y.T., and Chen H.C. Phosphorylation of adducin by protein kinase Cdelta promotes cell motility. J. Cell Sci. 120 (2007) 1157-1167
9. Damia G., and Broggini M. Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents. Cell Cycle 3 (2004) 46-50
10. Dehan E., and Pagano M. Skp2, the FoxO1 hunter. Cancer Cell 7 (2005) 209-210
11. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 12 (1998) 2245-2262
12. Frey M.R., Clark J.A., Leontieva O., Uronis J.M., Black A.R., and Black J.D. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium. J. Cell Biol. 151 (2000) 763-778
13. Gauthier M.L., Torretto C., Ly J., Francescutti V., and O'Day D.H. Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor. Biochem. Biophys. Res. Commun. 307 (2003) 839-846
14. Griner E.M., and Kazanietz M.G. Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer 7 (2007) 281-294
15. Kass G.E.N., Duddy S.K., and Orrenius S. Activation of hepatocyte protein kinase C by redox-cycling quinines. Biochem. J. 260 (1989) 499-507
16. Kharait S., Dhir R., Lauffenburger D., and Wells A. Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochem. Biophys. Res. Commun. 343 (2006) 848-856
17. Koike K., Fujii T., Nakamura A.M., Yokoyama G., Yamana H., Kuwano M., and Shirouzu K. Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase. Thyroid 16 (2006) 333-341
18. Kraiem Z., Sadeh O., Yosef M., and Aharon A. Mutual antagonistic interactions between the thyrotropin (adenosine 3′,5′-monophosphate) and protein kinase C/epidermal growth factor (tyrosine kinase) pathways in cell proliferation and differentiation of cultured human thyroid follicles. Endocrinology 136 (1995) 585-590
19. Levesque J.T., and Siard M.A. Effects of different kinases and phosphatases on nuclear and cytoplasmic maturation of bovine oocytes. Mol. Reprod. Dev. 42 (1995) 114-121
20. Liang J., and Slingerland J.M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2 (2003) 339-345
21. Liu B., Ryer E.J., Kundi R., Kamiya K., Itoh H., Faries P.L., Sakakibara K., and Kent K.C. Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2. J. Vasc. Surg. 45 (2007) 160-168
22. Lombardi A., Veneziani B.M., Tramontano D., and Ingbar S.H. Independent and interactive effects of tetradecanoyl phorbol acetate on growth and differentiated functions of FRTL5 cells. Endocrinology 123 (1988) 1544-1552
23. Martin P.M., Aeder S.E., Chrestensen C.A., Sturgill T.W., and Hussaini I.M. Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta. Oncogene 26 (2007) 407-414
24. Massague J. G1 cell-cycle control and cancer. Nature 432 (2004) 298-306
25. Medema R.H., Kops G.J., Bos J.L., and Burgering B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404 (2000) 782-787
26. Meloche S., and Pouyssegur J. The ERK 1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26 (2007) 3227-3239
27. Myatt S.S., and Lam E.W. The emerging roles of forkhead box (Fox) proteins in cancer. Nat. Rev. Cancer 7 (2007) 847-859
28. 1 phase arrest selectively mediated by protein kinase Cδ-dependent induction of p21. J. Biol. Chem. 280 (2005) 33926-33934
29. Newton A.C. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. 101 (2001) 2353-2364
30. Nevins J.R. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9 (1998) 585-593
31. Nishizuka Y. Studies and prespectives of protein kinase C. Science 233 (1986) 305-312
32. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334 (1988) 661-665
33. Perletti G., Marras E., Dondi D., Osti D., Congiu T., Ferrarese R., de Eguileor M., and Tashjian Jr. A.H. p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. Int. J. Cancer 113 (2005) 42-53
34. Pettersson F., Couture M.C., Hanna N., and Miller W.H. Enhanced retinoid-induced apoptosis of MDA-MB-231 breast cancer cells by PKC inhibitors involves activation of ERK. Oncogene 23 (2004) 7053-7066
35. Podtcheko A., Ohtsuru A., Tsuda S., Namba H., Saenko V., Nakashima M., Mitsutake N., Kanda S., Kurebayashi J., and Yamashita S. The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells. J. Clin. Endocrinol. Metab. 88 (2003) 1889-1896
36. Roger P.P., Reuse S., Servais P., Van Heuverswyn B., and Dumont J.E. Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture. Cancer Res. 46 (1986) 898-906
37. Sinibaldi D., Wharton W., Turkson J., Bowman T., Pledger W.J., and Jove R. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 19 (2000) 5419-5427
38. Shinohara M., Chung Y.J., Saji M., and Ringel M.D. Minireview: Akt in thyroid tumorigenesis and progression. Endocrinology 148 (2007) 942-947
39. Spofford L.S., Abel E.V., Boisvert-Adamo K., and Aplin A.E. Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progression. J. Biol. Chem. 281 (2006) 25644-25651
40. Takada K., Amino N., Tetsumoto T., and Miyai K. Phorbol esters have adual action through protein kinase C in regulation of proliferation on FRTL-5 cells. FEBS Lett. 234 (1988) 13-16
41. Yang H.L., Pan J.X., Sun L., and Yeung S.C. p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in apoptosis induced by manumycin and paclitaxel in anaplasticthyroid cancer cells. J. Clin. Endocrinol. Metab. 88 (2003) 763-772
42. Yokoyama G., Fujii T., Tayama K., Yamana H., Kuwano M., and Shirouzu K. PKCd and MAPK mediate G1 arrest induced by PMA in SKBR-3 breast cancer cells. Biochem. Biophys. Res. Commun. 327 (2005) 720-726