Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes

Peptides

Volumn 26, Issue 3, 2005, Pages 423-430

  Liu, Yu ^a   Lu, Wan Liang ^a   Zhang, Xuan ^a   Wang, Xue Qing ^a   Zhang, Hua ^a   Zhang, Qiang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Absorption; Non parenteral route; Pharmacodynamics; Pharmacokinetics; Recombinant hirudin

Indexed keywords

ANTICOAGULANT AGENT; CHROMOGENIC SUBSTRATE; POLYPEPTIDE; RECOMBINANT HIRUDIN; THROMBIN;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; ASSAY; BLOOD CLOTTING TIME; CALCULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG USE; HEMOCONCENTRATION; MALE; MEASUREMENT; MODEL; NONHUMAN; OUTPATIENT DEPARTMENT; PARAMETER; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; STANDARD; THROMBIN TIME; TIME;

ABSORPTION; ADMINISTRATION, BUCCAL; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; HIRUDINS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; THROMBIN TIME; TIME FACTORS; WHOLE BLOOD COAGULATION TIME;

EID: 12344333674     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.10.003     Document Type: Article

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