Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 14, Issue 5-6, 2013, Pages 424-433

  Kandinov, Boris ^a   Grigoriadis, Nikolaos C ^b   Touloumi, Olga ^b   Drory, Vivian E ^a   Offen, Daniel ^a   Korczyn, Amos D ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b AHEPA UNIVERSITY HOSPITAL   (Greece)

Author keywords

Adrenal gland; Amyotrophic lateral sclerosis; Autonomic function; Choline acetyltransferase; SOD1 G93A; Superior cervical ganglion; Transgenic animals; Tyrosine hydroxylase

Indexed keywords

CHOLINE ACETYLTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; TYROSINE 3 MONOOXYGENASE; UBIQUITIN;

ADRENAL GLAND; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NUCLEUS; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; PREGANGLIONIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERIOR CERVICAL GANGLION; TRANSGENIC MOUSE;

ADRENAL GLANDS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; CHOLINE O-ACETYLTRANSFERASE; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROFILAMENT PROTEINS; SPINAL CORD; SUPERIOR CERVICAL GANGLION; SUPEROXIDE DISMUTASE; SYMPATHETIC NERVOUS SYSTEM; TYROSINE 3-MONOOXYGENASE; UBIQUITIN;

EID: 84881356980     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2013.780622     Document Type: Article

References (36)

1. Swash M. C linical features and diagnosis of amyotrophic lateral sclerosis. In: Brown RH, Meininger V, Swash M, editors. Amyotrophic Lateral Sclerosis. London: Martin Dunitz; 2000. pp. 3-30
2. Baltadzhieva R, Gurevich T, Korczyn AD. A utonomic impairment in amyotrophic lateral sclerosis. Curr Opin Neurol. 2005 ; 18: 487-93
3. Kandinov B, Korczyn AD, Rabinowitz R, Nefussy B, Drory VE. Autonomic impairment in a transgenic mouse model of amyotrophic lateral sclerosis. Auton Neurosci. 2011 ; 159: 84-9
4. Kandinov B, Drory VE, Tordjman K, Korczyn AD. B lood pressure measurements in a transgenic SOD1-G93A mouse model of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2012 ; 13: 509-13
5. Gibbins I. P eripheral autonomic pathways. In: Paxinos G, Mai J, editors. The Human Nervous System, 2nd edn. Oxford: Elsevier Academic; 2004. pp. 134-89
6. Silverthorn D U. H uman physiology: An integrated approach, 4th edn. Pearson/Benjamin Cummings; 2009. pp. 379-86
7. Yoshimatsu H, Oomura Y, Katafuchi T, Niijima A. Effects of hypothalamic stimulation and lesion on adrenal nerve activity. Am J Physiol. 1987 ; 253: 418-24
8. Deiana S, Platt B, Riedel G. The cholinergic system and spatial learning. Behav Brain Res. 2011 ; 221: 389-411
9. Masserano JM, Weiner N. T yrosine hydroxylase regulation in the central nervous system. Mol Cell Biochem. 1983 ; 54: 129-52
10. Gurney ME, Pu H, Chiu A Y, Dal Canto MC, Polchow CY, Alexander DD, et al. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science. 1994 ; 164: 1772-5
11. L ougheed R, Turnbull J. L ack of effect of methylene blue in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. PLoS One. 2011; 6: 23141
12. Clark D. G uide for the Care and Use of Laboratory Animals. 2nd edn. Washington, DC: National Academy Press; 1996
13. Takahashi H, Oyanagi K, Ikuta F. The intermediolateral nucleus in sporadic amyotrophic lateral sclerosis. Acta Neuropathol (Berl). 1993 ; 86: 190-92
14. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, et al. An adverse property of a familial ALSlinked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 ; 14: 1105-16
15. Kong J, Xu Z. M assive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci. 1998 ; 18: 3241-50
16. Carpenter S. P roximal axonal enlargement in motor neuron diseases. Neurology. 1968 ; 18: 841-51
17. Sobue G, Hashizume Y, Yasuda T, Mukai E, Kumagai T, Mitsuma T, et al. Phosphorylated high molecular weight neurofi lament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells. Acta Neuropathol. 1990; 79: 402-8
18. Boylan KB, Glass JD, Crook JE, Yang C, Thomas CS, Desaro P, et al. Phosphorylated neurofi lamenTheavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2012. In Press
19. Keller B A, Volkening K, Droppelmann C A, Ang L C, Rademakers R, Strong MJ. Coaggregation of RNA binding proteins in ALS spinal motor neurons: Evidence of a common pathogenic mechanism. Acta Neuropathol. 2012 ; 124: 733-47
20. O ey PL, Vos PE, Wieneke GH, Wokke JHJ, Blankestijn PJ, Karemaker JM. Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis. Muscle Nerve. 2002 ; 25: 402-8
21. Shindo K, Watanabe H, Ohta E, Nagasaka T, Shiozawa Z, Takiyama Y. Sympathetic sudomotor neural function in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 ; 12: 39-44
22. Nakajima R, Takahashi K, Nakamura H, Otomo E, Kameyama M. A quantitative study on the intermediolateral cells of the thoracic cord in degenerative diseases of the nervous system (author's transl). Rinsho Shinkeigaku. 1981 ; 21: 581-6
23. Konno H, Yamamoto T, Iwasaki Y, Iizuka H. S hy-Drager syndrome and amyotrophic lateral sclerosis. Cytoarchitectonic and morphometric studies of sacral autonomic neurons. J Neurol Sci. 1986 ; 73: 193-204
24. Itoh T, Sobue G, Ken E, Mitsuma T, Takahashi A, Trojanowski JQ. Phosphorylated high molecular weight neurofi lament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: System-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy. Acta Neuropathol. 1992 ; 83: 240-5
25. Asai H, Hirano M, Udaka F, Shimada K, Oda M, Kubori T, et al. Sympathetic disturbances increase risk of sudden cardiac arrest in sporadic ALS. J Neurol Sci. 2007 ; 254: 78-83
26. Shimizu T, Kawata A, Kato S, Hayashi M, Takamoto K, Hayashi H, et al. Autonomic failure in ALS with a novel SOD1 gene mutation. Neurology. 2000 ; 54: 1534-7
27. Shimizu T, Hayashi H, Kato S, Hayashi M, Tanabe H, Oda MI. Circulatory collapse and sudden death in respirator-dependent amyotrophic lateral sclerosis. J Neurol Sci. 1994 ; 124: 45-55
28. Kasa P, Dobo E, Wolff JR. C holinergic innervation of the mouse SCG: Light and electron microscopic immunocytochemistry for choline acetyltransferase. Cell Tissue Res. 1991 ; 265: 151-8
29. Lindh B, Staines W, Hö k felt T, Terenius L, Salvaterra PM. Immunohistochemical demonstration of cholineacetyltransferase-immunoreactive preganglionic nerve fi bres in guineapig autonomic ganglia. Proc Natl Acad Sci USA. 1986 ; 83: 5316-20
30. Moura E, Costa DMP, Moura D, Guimaraes S, Vieira-Coelho MA. Decreased tyrosine hydroxylase activity in the adrenals of SHR. Life Science. 2005 ; 76: 2953-64
31. Ulus IH, Wurtman RJ. S elective response of rat peripheral sympathetic nervous system to various stimuli. J Physiol. 1979 ; 293: 513-23
32. Patrick R L, Kirshner N. D evelopmental changes in rat adrenal tyrosine hydroxylase, dopamine-®-hydroxylase and catecholamine levels: Effect of denervation. Devel Biol. 1972 ; 29: 204-13
33. Druschky A, Spitzer A, Platsch G, Claus D, Feistel H, Druschky K, et al. Cardiac sympathetic denervation in early stages of amyotrophic lateral sclerosis demonstrated by 123IMIBGSPECT. Acta Neurol Scand. 1999 ; 9: 308-14
34. Chida K, Sakamaki S, Takasu T. A lteration in autonomic function and cardiovascular regulation in amyotrophic lateral sclerosis. Neurology. 1989 ; 236: 127-30
35. Ohno T, Shimizu T, Sato S, Hayashi H, Hirai S. Effect of tamsulosin hydrochloride on sympathetic hyperactivity in amyotrophic lateral sclerosis. Auton Neurosci. 2001 ; 88: 94-8
36. Yamashita A, Koike Y, Takahashi A, Hirayama M, Murakami N, Sobue G. Relationship between respiratory failure and plasma noradrenaline levels in amyotrophic lateral sclerosis. Clin Auton Res. 1997 ; 7: 173-7