Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype

Obesity

Volumn 21, Issue 6, 2013, Pages 1174-1179

  Petäjä, Elina M ^a,b   Sevastianova, Ksenia ^a,b   Hakkarainen, Antti ^c   Orho Melander, Marju ^d   Lundbom, Nina ^c   Yki Järvinen, Hannele ^a,b  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL FAT; ABDOMINAL SUBCUTANEOUS FAT; ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGE; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CELL SIZE; CONTROLLED STUDY; DISEASE ASSOCIATION; FAT CONTENT; FEMALE; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; LIVER; LIVER FAT; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 GENE; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 84881351041     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20114     Document Type: Article

References (38)

1. McCullough AJ,. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8: 521-522.
2. Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of enthnicity. Hepatology 2004; 40: 1378-1395.
3. Kotronen A, Westerbacka J, Bergholm R, et al. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab 2007; 92: 3490-3497.
4. Yki-Järvinen H,. Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. Dig Dis 2010; 28: 203-209.
5. Cohen JC, Horton JD, Hobbs HH,. Human fatty liver disease: old questions and new insights. Science 2011; 332: 1519-1523.
6. Romeo S, Huang-Doran I, Baroni MG, et al. Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein. Curr Opin Lipidol 2010; 21: 247-252.
7. Sookoian S, Pirola CJ,. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011; 53: 1883-1894.
8. Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808.
9. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
10. Lundgren M, Svensson M, Lindmark M, et al. Fat cell enlargement is an independent marker of insulin resistance and "hyperleptinaemia." Diabetologia 2007; 50: 625-633.
11. Zeyda M, Stulnig TM,. Obesity, inflammation and insulin resistance-a mini-review. Gerontology 2009; 55: 379-386.
12. Santoro N, Kursawe R, D'Adamo E, et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology 2010; 52: 1281-1290.
13. Kotronen A, Peltonen M, Hakkarainen A, et al. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 2009; 137: 865-872.
14. Kotronen A, Johansson LE, Johansson LM, et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009; 52: 1056-1060.
15. Yki-Järvinen H, Nikkilä EA, Kubo K, et al. Assay of glucose transport in human fat cells obtained by needle biopsy. Diabetologia 1986; 29: 287-290.
16. Ryysy L, Häkkinen AM, Goto T, et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 2000; 49: 749-775.
17. Kotronen A, Vehkavaara S, Seppälä-Lindroos A, et al. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab 2007; 293: 1709-1715.
18. Machann J, Thamer C, Schnoedt B, et al. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 2006; 55: 913-917.
19. Szczepaniac LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: 462-468.
20. Rodbell M,. Metabolism of isolated fat cells. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964; 239: 375-380.
21. Abate N, Burns D, Peshock RM, et al. Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers. J Lipid Res 1994; 35: 1490-1496.
22. Friedewald WT, Levy RI, Fredrickson DS,. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
23. Koska J, Stefan N, Permana PA, et al. Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity and hypoadiponectinemia in obese individuals. Am J Clin Nutr 2008; 87: 295-302.
24. O'Connell J, Lynch L, Cawood TJ, et al. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One 2010; 5: e999.
25. Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87: 3023-3028.
26. Adiels M, Taskinen MR, Packard C, et al. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 2006; 49: 755-765.
27. Guilherme A, Virbasius JV, Puri B, et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9: 367-377.
28. Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissues of obese mice and humans. J Lipid Res 2005; 46: 2347-2355.
29. Alhkouri N, Gornicka A, Berk MP, et al. Adipocyte apoptosis, a link between obesity, insulin resistance and hepatic steatosis. J Biol Chem 2010; 285: 3428-3438.
30. Ryden M, Arner P,. Tumor necrosis factor-alpha in human adipose tissue-from signaling mechanisms to clinical implications. J Intern Med 2007; 262: 431-438.
31. Salans LB, Knittle L, Hirsch J,. The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. J Clin Invest 1968; 47: 153-165.
32. Donnelly KL, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351.
33. Weyer C, Foley JE, Bogardus C, et al. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 2000; 43: 1498-1506.
34. Hoffstedt J, Arner E, Wahrenberg H, et al. Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia 2010; 53: 2496-2250.
35. Kotronen A, Yki-Järvinen H,. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008; 28: 3827-3834.
36. Kotronen A, Joutsi-Korhonen L, Sevastianova K, et al. Increased coagulation factor VIII, IX and XII activities in nonalcoholic fatty liver disease. Liver Int 2011; 31: 1761-1783.
37. Lönn M, Mehlig K, Bengtsson C, et al. Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 2009; 24: 326-331.
38. Lee DH, Silventoinen K, Jacobs DR Jr, et al. gamma-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women. J Clin Endocrinol Metab 2004; 89: 5410-5414.