The impact of genetics profile (Gene polymorphisms) in Obese Non-PCOS women entering an IVF/ICSI program

Current Drug Targets

Volumn 14, Issue 8, 2013, Pages 850-855

  Anagnostou, Elli ^a   Drakakis, Petros ^a   Marinopoulos, Spyridon ^a   Mavrogianni, Despina ^a   Loutradis, Dimitrios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

ESR1 gene; ESR2 gene; FSH receptor gene; IVF ICSI; Obesity; Single nucleotide polymorphisms

Indexed keywords

BUSERELIN; BUSERELIN ACETATE; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FOLLITROPIN; FOLLITROPIN RECEPTOR; GONADOTROPIN; LUTEINIZING HORMONE; PROLACTIN;

ADULT; ARTICLE; BODY MASS; CHEMILUMINESCENCE IMMUNOASSAY; ECHOGRAPHY; FEMALE; FERTILIZATION IN VITRO; FOLLICULAR ASPIRATION; FOLLOW UP; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; OOCYTE RETRIEVAL; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY OUTCOME; PREGNANCY RATE; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSVAGINAL ECHOGRAPHY;

ADULT; BODY MASS INDEX; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENOTYPE; HUMANS; OBESITY; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY OUTCOME; RECEPTORS, FSH; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 84881346399     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450111314080004     Document Type: Article

References (46)

1. Kirschner MA, Schneider G, Ertel NH, Worton E. Obesity, androgens, estrogens, and cancer risk. Cancer Res 1982; 42(Suppl 8): 3281s-3285s.
2. Pasquali R, Casimirri F. The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clin Endocrinol (Oxf) 1993; 39(1): 1-16.
3. Norman RJ, Clark AM. Obesity and reproductive disorders: a review. Reprod Fertil Dev 1998; 10(1): 55-63.
4. Pasquali R, Pelusi C, Genghini S, Cacciari M, Gambineri A. Obesity and reproductive disorders in women. Hum Reprod Update 2003; 9(4): 359-372.
5. Loveland JB, McClamrock HD, Malinow AM, Sharara FI. Increased body mass index has a deleterious effect on in vitro fertilization outcome. J Assist Reprod Genet 2001; 18(7): 382-386.
6. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev 2002; 11(12): 1531-43.
7. Hall LF, Neubert AG. Obesity and pregnancy. Obstet Gynecol Surv 2005; 60(4): 253-60.
8. Crosignani PG, Ragni G, Parazzini F, Wyssling H, Lombroso G, Perotti L. Anthropometric indicators and response to gonadotrophin for ovulation induction. Hum Reprod 1994; 9(3): 420-3.
9. Zhang D, Zhu Y, Gao H, et al. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol Endocrinol 2010; 26(5): 325-32.
10. Spandorfer SD, Kump L, Goldschlag D, Brodkin T, Davis OK, Rosenwaks Z. Obesity and in vitro fertilization: negative influences on outcome. J Reprod Med 2004; 49(12): 973-7.
11. Bellver J, Melo MA, Bosch E, Serra V, Remohí J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007; 88(2): 446-51.
12. Bellver J, Ayllón Y, Ferrando M, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010; 93(2): 447-54.
13. Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis BJ, Sparks A. Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol 2006; 108(1): 61-9.
14. Fedorcsák P, Dale PO, Storeng R, et al. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 2004; 19(11): 2523-8.
15. Tamer Erel C, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol 2009; 21(3): 228-35.
16. Vilarino FL, Christofolini DM, Rodrigues D, et al. Body mass index and fertility: is there a correlation with human reproduction outcomes? Gynecol Endocrinol 2011; 27(4): 232-6.
17. Dechaud H, Anahory T, Reyftmann L, Loup V, Hamamah S, Hedon B. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2006; 127(1): 88-93.
18. Georgiou I, Konstantelli M, Syrrou M, Messinis IE, Lolis DE. Oestrogen receptor gene polymorphisms and ovarian stimulation for in-vitro fertilization. Hum Reprod 1997; 12(7): 1430-3.
19. Sundarrajan C, Liao WX, Roy AC, Ng SC. Association of oestrogen receptor gene polymorphisms with outcome of ovarian stimulation in patients undergoing IVF. Mol Hum Reprod 1999; 5(9): 797-802.
20. Altmäe S, Haller K, Peters M, et al. Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization. Mol Hum Reprod 2007; 13(8): 521-6.
21. Simoni M, Nieschlag E, Gromoll J. Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Hum Reprod Update 2002; 8(5): 413-21.
22. Jun JK, Yoon JS, Ku SY, et al. Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET. J Hum Genet 2006; 51(8): 665-70.
23. Loutradis D, Patsoula E, Minas V, et al. FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs. J Assist Reprod Genet 2006; 23(4): 177-84.
24. Klinkert ER, te Velde ER, Weima S, et al. FSH receptor genotype is associated with pregnancy but not with ovarian response in IVF. Reprod Biomed Online 2006; 13(5): 687-95.
25. de Castro F, Ruiz R, Montoro L, et al. Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone. Fertil Steril 2003; 80(3): 571-6.
26. Anagnostou E, Mavrogianni D, Theofanakis Ch, et al. ESR1, ESR2 and FSH Receptor gene polymorphisms in combination: a useful genetic tool for the prediction of poor responders. Curr Pharm Biotechnol 2012; 13(3): 426-34.
27. Simoni M, Tempfer CB, Destenaves B, Fauser BCJM. Functional genetic polymorphisms and female reproductive disorders: Part I: polycystic ovary syndrome and ovarian response. Hum Reprod Update 2008; 14(5): 459-84.
28. Park JM, Lee EJ, Ramakrishna S, Cha DH, Baek KH. Association study for single nucleotide polymorphisms in the CYP17A1 gene and polycystic ovary syndrome. Int J Mol Med 2008; 22(2): 249-54.
29. de Castro F, Moron FJ, Montoro L, et al. Human controlled ovarian hyperstimulation outcome is a polygenic trait. Pharmacogenetics 2004; 14(5): 285-93.
30. Drakakis P, Loutradis D, Kallianidis K et al. A comparative study of the effect of ovarian stimulation protocols with different gonadotropin preparations on the biological and clinical parameters of the outcome of intracytoplasmic sperm injection. Int Clin Exp Obstet Gynecol 2002; 4: 286-9.
31. Loutradis D, Drakakis P, Kallianidis K, Milingos S, Dendrinos S, Michalas S. Oocyte morphology correlates with embryo quality and pregnancy rate after intracytoplasmic sperm injection. Fertil Steril 1999; 72(2): 240-4.
32. Loutradis D, Drakakis P, Milingos S, Stefanidis K, Michalas S. Alternative approaches in the management of poor response in controlled ovarian hyperstimulation (COH). Ann NY Acad Sci 2003; 997: 112-9.
33. Dierich A, Sairam MR, Monaco L, et al. Impairing folliclestimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci USA 1998; 95(23): 13612-7.
34. Grumbach MM, Auchus RJ. Related estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 1999; 84(12): 4677-94.
35. Ukkola O, Rankinen T, Gagnon J et al. A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study. J Clin Endocrinol Metab 2002; 87(8): 3708-20.
36. Tonetta SA, Spicer LJ, Ireland JJ. CI628 inhibits folliclestimulating hormone (FSH)-induced increases in FSH receptors of the rat ovary: requirement of estradiol for FSH action. Endocrinology 1985; 116(2): 715-22.
37. Ireland JJ, Richards JS. Acute effects of estradiol and folliclestimulating hormone on specific binding of human [125I]iodofollicle-stimulating hormone to rat ovarian granulosa cells in vivo and in vitro. Endocrinology 1978; 102(3): 876-83.
38. Gosman GG, Katcher HI, Legro RS. Obesity and the role of gut and adipose hormones in female reproduction. Hum Reprod Update 2006; 12(5): 585-601.
39. Lintsen AM, Pasker-de Jong PC, de Boer EJ, et al. Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod 2005; 20(7): 1867-75.
40. Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology-a systematic review. Hum Reprod Update 2007; 13(5): 433-44.
41. Lashen H, Ledger W, Bernal AL, Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and invitro fertilization. Hum Reprod 1999; 14(3): 712-5.
42. Wattanakumtornkul S, Damario MA, Stevens Hall SA, Thornhill AR, Tummon IS. Body mass index and uterine receptivity in the oocyte donation model. Fertil Steril 2003; 80(2): 336-40.
43. Imani B, Eijkemans MJ, Faessen GH, Bouchard P, Giudice LC, Fauser BC. Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency. Fertil Steril 2002; 77(1): 83-90.
44. Patsoula E, Loutradis D, Drakakis P, Michalas L, Bletsa R, Michalas S. mRNA expression for the follicle stimulating hormone receptor and luteinizing hormone receptor in human oocytes and preimplantation stage embryos. Fertil Steril 2003; 79(5): 1187-93.
45. van der Steeg JW, Steures P, Eijkemans MJ, et al. Predictive value and clinical impact of Basal follicle-stimulating hormone in subfertile, ovulatory women. J Clin Endocrinol Metab 2007; 92(6): 2163-8.
46. Schüring AN, Lutz F, Tüttelmann F, Gromoll J, Kiesel L, Götte M. Role of syndecan-3 polymorphisms in obesity and female hyperandrogenism. J Mol Med 2009; 87(12): 1241-50.