FSH receptor genotype is associated with pregnancy but not with ovarian response in IVF

Reproductive BioMedicine Online

Volumn 13, Issue 5, 2006, Pages 687-695

  Klinkert, Ellen R ^a   te Velde, Egbert R ^a   Weima, Sjerp ^a   van Zandvoort, Peter M ^b   Hanssen, Rob G J M ^b   Nilsson, Philomeen R ^a   de Jong, Frank H ^c   Looman, Caspar W N ^c   Broekmans, Frank J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NV ORGANON   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

FSH receptor; Implantation rate; IVF; Polymorphism; Poor response; Pregnancy rate

Indexed keywords

ASPARAGINE; BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN; CYCLIC AMP; FOLLITROPIN; FOLLITROPIN RECEPTOR; LEUPRORELIN; MUELLERIAN INHIBITING FACTOR; PROGESTERONE; RECOMBINANT FOLLITROPIN; SERINE;

ADULT; AGE; ARTICLE; CELL CULTURE; CLINICAL PROTOCOL; CONTROLLED STUDY; EMBRYO; FEMALE; FERTILIZATION IN VITRO; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GRANULOSA CELL; HORMONE ACTION; HORMONE INHIBITION; HORMONE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; NIDATION; NUCLEOTIDE METABOLISM; OBSERVATIONAL STUDY; OVARY FOLLICLE; OVARY FUNCTION; OVULATION INDUCTION; PREDICTION; PREGNANCY; PREGNANCY RATE;

EID: 33751074478     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)60660-8     Document Type: Article

References (35)

1. Aittomaki K, Lucena JL, Pakarinen P et al. 1995 Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 82, 959-968.
2. Albertini DF, Combelles CM, Benecchi E et al. 2001 Cellular basis for paracrine regulation of ovarian follicle development. Reproduction 121, 647-653.
3. Anderiesz C, Ferraretti A-P, Magli C et al. 2000 Effect of recombinant human gonadotrophins on human, bovine and murine oocyte meiosis, fertilization and embryonic development in vitro. Human Reproduction 15, 1140-1148.
4. Bancsi LF, Broekmans FJ, Eijkemans MJ et al. 2002 Predictors of poor ovarian response in in-vitro fertilization: a prospective study comparing basal markers of ovarian reserve. Fertility and Sterility 77, 328-336.
5. Behre HM, Greb RR, Mempel A et al. 2005 Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation. Pharmacogenetics and Genomics 15, 451-456.
6. Calder MD, Caveney AN Sirard MA, Watson AJ 2005 Effect of serum and cumulus expansion on marker gene transcripts in bovine cumulus oocyte complexes during maturation in vitro. Fertility and Sterility 83, 1077-1085.
7. Calder MD, Caveney AN, Smith LC et al. 2003 Responsiveness of cumulus oocyte complexes (COC) to porcine and recombinant human FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro. Reproductive Biology and Endocrinology 11, 1-14.
8. Chen L, Russell PT, Larsen WJ et al. 1994 Sequential effects of follicle stimulating hormone and luteinizing hormone on mouse cumulus expansion in vitro. Biology of Reproduction 51, 290-295.
9. Conway GS, Conway E, Walker C et al. 1999 Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome. Clinical Endocrinology 51, 97-99.
10. Daelemans C, Smits G, de Maertelaer V et al. 2004 Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism. Journal of Clinical Endocrinology and Metabolism 89, 6310-6315.
11. de Castro F, Ruiz R, Montoro L et al. 2003 Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone. Fertility and Sterility 80, 571-576.
12. de Koning CH, Benjamins T, Harms P et al. 2006 The distribution of FSH receptor isoforms is related to basal FSH levels in subfertile women with normal menstrual cycles. Human Reproduction 21, 443-446.
13. Falconer H, Andersson E, Aanesen A et al. 2005 Follicle-stimulating hormone receptor polymorphisms in a population of infertile women. Acta Obstetricia et Gynecologica Scandinavica 84, 806-811.
14. Gonzalez-Robayna IJ, Falender AE, Ochsner S et al. 2000 Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells. Molecular Endocrinology 14, 1283-1300.
15. Greb RR, Grieshaber K, Gromoll J et al. 2005 A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. Journal of Clinical Endocrinology and Metabolism 90, 4866-4872.
16. Gromoll J, Ried T, Holtgreve-Grez H et al. 1994 Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10. Journal of Molecular Endocrinology 12, 265-271.
17. Keck C, Bassett R, Ludwich M 2005 Factors influencing response to ovarian stimulation. Reproducuve BioMedicine Online 11, 562-569.
18. Klinkert ER, Broekmans FJ, Looman CW et al. 2004 A poor response in the first in-vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles. Fertility and Sterility 81, 1247-1253.
19. Laven JS, Mulders AG, Suryandari DA et al. 2003 Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility. Fertility and Sterility 80, 986-992.
20. Loutradis D, Patsoula E, Minas V et al. 2006 FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs. Journal of Assisted Reproduction and Genetics 23, 177-184.
21. Ng EH, Tang OS, Ho PC 2000 The significance of the number of antral follicles prior to stimulation in predicting ovarian responses in an IVF programme. Human Reproduction 15, 1937-1942.
22. Oktay K, Briggs D, Gosden RG 1997 Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. Journal of Clinical Endocrinology and Metabolism 82, 3748-3751.
23. Palmer SS, McKenna S, Arkinstall S 2005 Discovery of new molecules for future treatment of infertilty. Reproductive BioMedicine Online 10 (Suppl. 3), 45-54.
24. Perez Mayorga M, Gromoll J, Behre HM et al. 2000 Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. Journal of Clinical Endocrinology and Metabolism 85, 3365-3369.
25. Popovic-Todorovic B, Loft A, Bredkjaeer HE et al. 2003 A prospective randomized clinical trial comparing an individual dose of recombinant FSH based on predictive factors versus a 'standard' dose of 150 IU/day in 'standard' patients undergoing IVF/ICSI treatment. Human Reproduction 18, 2275-2282.
26. Richards JS 1994 Hormonal control of gene expression in the ovary. Endocrine Reviews. 15, 725-751.
27. Rousseau-Merck MF, Atger M, Loosfelt H et al. 1993 The chromosomal localization of the human follicle-stimulating hormone receptor gene (FSHR) on 2p21-p16 is similar to that of the luteinizing hormone receptor gene. Genomics 15, 222-224.
28. Segaloff DL, Wang HY, Richards JS 1990 Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinization. Molecular Endocrinoology 4, 1856-1865.
29. Shemesh M 2001 Actions of gonadotrophins on the uterus. Reproduction 121, 835-842.
30. Simoni M, Nieschlag E, Gromoll J 2002 Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Human Reproduction Update 8, 413-421.
31. Simoni M, Gromoll J, Hoppner W et al. 1999 Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men: identification and characterization of two discrete FSH receptor isoforms. Journal of Clinical Endocrinology and Metabolism 84, 751-755.
32. Simoni M, Gromoll J, Nieschlag E 1997 The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocrine Reviews 18, 739-773.
33. Sudo S, Kudo M, Wada S et al. 2002 Genetic and functional analyses of polymorphisms in the human FSH receptor gene. Molecular Human Reproduction 8, 893-899.
34. van Kooij RJ, Looman CW, Habbema JD et al. 1996 Age-dependent decrease in embryo implantation rate after in-vitro fertilization. Fertility and Sterility 66, 769-775.
35. Zeleznik AJ, Saxena D, Little-Ihrig L 2003 Proteine Kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation. Endocrinology 144, 3985-3994.