miR-105 Inhibits Prostate Tumour Growth by Suppressing CDK6 Levels

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Honeywell, D Rice ^a,b   Cabrita, Miguel A ^a,b   Zhao, Huijun ^a   Dimitroulakos, Jim ^a,b,c   Addison, Christina L ^a,b,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; MICRORNA; MICRORNA 105; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PROSTATE CARCINOMA; TUMOR INVASION;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 6; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, NUDE; MICRORNAS; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

EID: 84881336254     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070515     Document Type: Article

References (51)

1. Lee RC, Feinbaum RL, Ambros V, (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
2. Wightman B, Ha I, Ruvkun G, (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862.
3. Winter J, Jung S, Keller S, Gregory RI, Diederichs S, (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234.
4. Lee Y, Ahn C, Han J, Choi H, Kim J, et al. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419.
5. Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U, (2004) Nuclear export of microRNA precursors. Science 303: 95-98.
6. Lee Y, Kim M, Han J, Yeom KH, Lee S, et al. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23: 4051-4060.
7. Gregory RI, Chendrimada TP, Shiekhattar R, (2006) MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol 342: 33-47.
8. Lee I, Ajay SS, Yook JI, Kim HS, Hong SH, et al. (2009) New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sites. Genome Res 19: 1175-1183.
9. He L, Hannon GJ, (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522-531.
10. Calin GA, Croce CM, (2006) MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 66: 7390-7394.
11. van Rooij E, Olson EN, (2007) MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest 117: 2369-2376.
12. Kolfschoten IG, Roggli E, Nesca V, Regazzi R, (2009) Role and therapeutic potential of microRNAs in diabetes. Diabetes Obes Metab 11Suppl 4: 118-129.
13. Sevli S, Uzumcu A, Solak M, Ittmann M, Ozen M, (2010) The function of microRNAs, small but potent molecules, in human prostate cancer. Prostate Cancer Prostatic Dis 13: 208-217.
14. Gordanpour A, Nam RK, Sugar L, Seth A (2012) MicroRNAs in prostate cancer: from biomarkers to molecularly-based therapeutics. Prostate Cancer Prostatic Dis.
15. Hassan O, Ahmad A, Sethi S, Sarkar FH, (2012) Recent updates on the role of microRNAs in prostate cancer. J Hematol Oncol 5: 9.
16. Xu B, Niu X, Zhang X, Tao J, Wu D, et al. (2011) miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Mol Cell Biochem 350: 207-213.
17. Sikand K, Slaibi JE, Singh R, Slane SD, Shukla GC, (2011) miR 488* inhibits androgen receptor expression in prostate carcinoma cells. Int J Cancer 129: 810-819.
18. Aqeilan RI, Calin GA, Croce CM, (2010) miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 17: 215-220.
19. Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi AH, et al. (2009) miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth. Cancer Res 69: 7165-7169.
20. Corcoran C, Friel AM, Duffy MJ, Crown J, O'Driscoll L, (2011) Intracellular and extracellular microRNAs in breast cancer. Clin Chem 57: 18-32.
21. Gao W, Xu J, Liu L, Shen H, Zeng H, et al. (2012) A systematic-analysis of predicted miR-21 targets identifies a signature for lung cancer. Biomed Pharmacother 66: 21-28.
22. Dong CG, Wu WK, Feng SY, Wang XJ, Shao JF, et al. (2012) Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. Int J Oncol.
23. Bader AG, (2012) miR-34 - a microRNA replacement therapy is headed to the clinic. Front Genet 3: 120.
24. Lee EJ, Baek M, Gusev Y, Brackett DJ, Nuovo GJ, et al. (2008) Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA 14: 35-42.
25. Sirotkin AV, Laukova M, Ovcharenko D, Brenaut P, Mlyncek M, (2010) Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. J Cell Physiol 223: 49-56.
26. Mazar J, Khaitan D, DeBlasio D, Zhong C, Govindarajan SS, et al. (2011) Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma. PLoS One 6: e24922.
27. Tie J, Pan Y, Zhao L, Wu K, Liu J, et al. (2010) MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 6: e1000879.
28. Kole AJ, Swahari V, Hammond SM, Deshmukh M, (2011) miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev 25: 125-130.
29. Blazejczyk M, Miron M, Nadon R (2007) FlexArray: A statistical data analysis software for gene expression microarrays. Montreal, Canada: Genome Quebec.
30. Gandellini P, Folini M, Longoni N, Pennati M, Binda M, et al. (2009) miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res 69: 2287-2295.
31. Kong D, Li Y, Wang Z, Banerjee S, Ahmad A, et al. (2009) miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 27: 1712-1721.
32. Lin SL, Chiang A, Chang D, Ying SY, (2008) Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14: 417-424.
33. Carlsson J, Helenius G, Karlsson M, Lubovac Z, Andren O, et al. (2010) Validation of suitable endogenous control genes for expression studies of miRNA in prostate cancer tissues. Cancer Genet Cytogenet 202: 71-75.
34. Peltier HJ, Latham GJ, (2008) Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 14: 844-852.
35. Ortega S, Malumbres M, Barbacid M, (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602: 73-87.
36. Lim JT, Mansukhani M, Weinstein IB, (2005) Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells. Proc Natl Acad Sci U S A 102: 5156-5161.
37. Lucas JJ, Domenico J, Gelfand EW, (2004) Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells. Mol Cancer Res 2: 105-114.
38. Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, et al. (2009) Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology 9: 293-301.
39. Wu J, Qian J, Li C, Kwok L, Cheng F, et al. (2010) miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell Cycle 9: 1809-1818.
40. Yang X, Feng M, Jiang X, Wu Z, Li Z, et al. (2009) miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 23: 2388-2393.
41. Fahraeus R, Lane DP, (1999) The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J 18: 2106-2118.
42. Dean JL, McClendon AK, Hickey TE, Butler LM, Tilley WD, et al. (2012) Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell Cycle 11: 2756-2761.
43. Konecny GE, Winterhoff B, Kolarova T, Qi J, Manivong K, et al. (2011) Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer. Clin Cancer Res 17: 1591-1602.
44. Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, et al. (2010) A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18: 303-315.
45. Yi R, Doehle BP, Qin Y, Macara IG, Cullen BR, (2005) Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11: 220-226.
46. Schaefer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, et al. (2010) Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int J Cancer 126: 1166-1176.
47. Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW, (1979) Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 17: 16-23.
48. Mickey DD, Stone KR, Wunderli H, Mickey GH, Paulson DF, (1980) Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. Prog Clin Biol Res 37: 67-84.
49. Boll K, Reiche K, Kasack K, Morbt N, Kretzschmar AK, et al. (2013) MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma. Oncogene 32: 277-285.
50. Wach S, Nolte E, Szczyrba J, Stohr R, Hartmann A, et al. (2012) MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening. Int J Cancer 130: 611-621.
51. Wang W, Peng B, Wang D, Ma X, Jiang D, et al. (2011) Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets. Int J Cancer 129: 1624-1634.