Characterization of physiochemical and biological properties of spherical protein crystals for sustained release

Asian Journal of Pharmaceutical Sciences

Volumn 8, Issue 1, 2013, Pages 58-63

  Shi, Kai ^a   Bi, Hongshu ^b   Jianga, Yanbo ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Liaoning Satellite Biotechnology Products Research Institute   (China)

Author keywords

Characterization; Protein; Spherical crystal; Sustained release

Indexed keywords

METAL ION; RECOMBINANT ALPHA2B INTERFERON;

ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYTOPATHOGENIC EFFECT; HANGING DROP VAPOR DIFFUSION METHOD; HUMAN; IN VITRO STUDY; MORPHOLOGY; PARTICLE SIZE; PROTEIN ANALYSIS; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION;

EID: 84881326162     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajps.2013.07.007     Document Type: Article

References (21)

1. Carter PJ. Introduction to current and future protein therapeutics: a protein engineering perspective. Exp Cell Res. 2011, 317:1261-1269.
2. Szlachcic A, Zakrzewska M, Otlewski J. Longer action means better drug: tuning up protein therapeutics. Biotechnol Adv. 2011, 29: 436-441.
3. Rathore N, Rajan RS. Current perspectives on stability of protein drug products during formulation, fill and finish operations. Biotechnol. Prog. 2008, 24: 504-514.
4. Degim IT, Celebi N. Controlled delivery of peptides and proteins. Curr. Pharm. Des. 2007, 13: 99-117.
5. Greenwald RB, Choe YH, McGuire J, et al. Effective drug delivery by PEGylated drug conjugates. Adv. Drug. Deliv. Rev. 2003, 55: 217-50.
6. Chemmanur AT, Wu GY. Drug evaluation: Albuferon-alpha-an antiviral interferon-alpha/albumin fusion protein. Curr. Opin. Investig. Drugs. 2006, 7: 750-758.
7. Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J. Control. Release. 2003, 90: 261-280.
8. Basu SK, Govardhan CP, Jung CW, et al. Protein crystals for the delivery of biopharmaceuticals. Expert. Opin. Biol. Ther. 2004, 4: 301-317.
9. Jen A, Merkle HP. Diamonds in the rough: protein crystals from a formulation perspective. Pharm. Res. 2001, 18: 1483-1488.
10. Brader ML, Sukumar M, Pekar AH. Hybrid insulin cocrystals for controlled release delivery. Nat. Biotechnol. 2002, 20: 800-804.
11. Luft JR, DeTitta GT. HANGMAN: a macromolecular hanging drop vapor diffusion technique. J Appl Cryst. 1992, 25: 324-325.
12. Basu SK, Govardhan CP, Jung CW, et al. Protein crystals for the delivery of biopharmaceuticals. Expert. Opin. Biol. Ther. 2004, 4: 301-317.
13. Jen A, Merkle HP. Diamonds in the rough: protein crystals from a formulation perspective. Pharm. Res. 2001, 18: 1483-1488.
14. Wiencek JM. New strategies for protein crystal growth. Annu Rev Biomed Eng. 1999, 1: 505-34.
15. McPherson A. Current approaches to macromolecular crystallization. Eur J Biochem. 189: 1990-1991.
16. Karpusas M, Nolte M, Benton CB, et al. The crystal structure of human interferon beta at 2.2-A resolution. Proc Natl Acad Sci U S A, 1997, 94: 11813-11818.
17. Radhakrishnan R, Walter LJ, Hruza A, et al. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. Structure. 1996, 4: 1453-1463.
18. Venyaminov YS, Yang JT. Determination of protein secondary structure. In Fasman GD. Circular dichroism and the conformational analysis of biomolecules. New York: Plenum; 1996. 69-107.
19. Zhang P, Chen L, Gu W, Xu Z, Gao Y, Li Y. In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease. Biomaterials. 2007, 28: 1882-1888.
20. Le Ray AM, Chiffoleau S, Iooss P, Grimandi G, Gouyette A, Daculsi G, et al. Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility. Biomaterials. 2003, 24: 443-449.
21. Flory PJ. Molecular morphology in semicrystalline polymers. Nature. 1978, 272: 226-229.