An undetectable polymerase chain reaction signal in routine HIV plasma viral load monitoring is associated with better virological outcomes in patients receiving highly active antiretroviral therapy

HIV Medicine

Volumn 14, Issue 8, 2013, Pages 509-515

  Pugliese, P ^a,k   Delpierre, C ^b   Cuzin, L ^c,k   Poizot Martin, I ^d,e,k   Rey, D ^f,k   Saune, K ^c   Cottalorda, J ^a,k   Bettinger, D ^g   Delaugerre, C ^h,i   Hoen, B ^g,j,k   Enel, P ^k   Obry Roguet, V ^k   Faucher, O ^k   Bregigeon, S ^k   Marchou, B ^k   Massip, P ^k   Bonnet, E ^k   Obadia, M ^k   Alvarez, M ^k   Porte, L ^k   Chauveau, M ^k   Lepain, I ^k   Bentz, L ^k   Ceppi, C ^k   Cua, E ^k   Durant, J ^k   Ferrando, S ^k   Fuzibet, J G ^k   Garraffo, R ^k   Naqvi, A ^k   Mondain, V ^k   Perbost, I ^k   Pillet, S ^k   Prouvost Keller, B ^k   Pradier, C ^k   Pugliese, S ^k   Roger, P M ^k   Sanderson, F ^k   Rahelinirina, V ^k   Rosenthal, E ^k   Vassallo, M ^k   Dellamonica, P ^k   Allavena, C ^k   Billaud, E ^k   Biron, C ^k   Bonnet, B ^k   Bouchez, S ^k   Boutoille, D ^k   Brunet Francois C ^k   Feuillebois, N ^k   Jovelin, T ^k   Mounoury, O ^k   Morineau, P ^k   Raffi, F ^k   Reliquet, V ^k   Hue, H ^k   Brosseau, D ^k   Yazdanpanah, Y ^k   Choisy, P ^k   Duvivier, C ^k   Valantin, M A ^k   Agher, R ^k   Katlama, C ^k   Shoai Tehrani, M ^k   Lortholary, O ^k   Consigny, P H ^k   Cessot, G ^k   Touam, F ^k   Benhadj, K ^k   Cabie A ^k   Abel, S ^k   Pierre Francois S ^k   Liautaud, B ^k   Ebel, E ^k   Fischer, P ^k   Partisani, M ^k   Chirouze, C ^k   Drobacheff Thiebaut C ^k   Faller, J P ^k   Faucher, J F ^k   Foltzer, A ^k   Gil, H ^k   Hustache Mathieu, L ^k   Bourdeaux, C ^k   more..

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c CHU PURPAN   (France)

^d AIX MARSEILLE UNIV   (France)

^e HÔPITAL SAINTE MARGUERITE   (France)

^f UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^g UNIVERSITY HOSPITAL OF BESANÇON   (France)

^h INSERM   (France)

ⁱ SAINT LOUIS HOSPITAL   (France)

^j UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^k NONE

more..

Author keywords

Blip; Detection; HIV; Low level viraemia; Plasma viral load; Quantification; Virological failure

Indexed keywords

ADULT; ARTICLE; DATA BASE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INCIDENCE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MEASUREMENT; MULTICENTER STUDY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT DURATION; VIREMIA; VIRUS DETECTION; VIRUS LOAD;

BLIP; DETECTION; HIV; LOW-LEVEL VIRAEMIA; PLASMA VIRAL LOAD; QUANTIFICATION; VIROLOGICAL FAILURE;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; FRANCE; HIV SEROPOSITIVITY; HUMANS; MALE; MIDDLE AGED; PLASMA; POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL LOAD;

EID: 84881314586     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/hiv.12041     Document Type: Article

References (17)

1. Gill VS, Lima VD, Zhang W etal. Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis 2010; 50: 98-105.
2. Moore RD, Bartlett JG. Dramatic decline in the HIV-1 RNA level over calendar time in a large urban HIV practice. Clin Infect Dis 2011; 53: 600-604.
3. Thompson MA, Aberg JA, Cahn P etal. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel. JAMA 2010; 304: 321-333.
4. Palmer S, Maldarelli F, Wiegand A etal. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci U S A 2008; 105: 3879-3884.
5. Sire JM, Vray M, Merzouk M etal. Comparative RNA quantification of HIV-1 group M and non-M with the Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 v2.0 and Abbott Real-Time HIV-1 PCR assays. J Acquir Immune Defic Syndr 2011; 56: 239-243.
6. Doyle T, Smith C, Vitiello P etal. Plasma HIV-1 RNA detection below 50 copies/mL and risk of virologic rebound in patients receiving highly active antiretroviral therapy. Clin Infect Dis 2012; 54: 724-732.
7. Pugliese P, Cuzin L, Cabie A etal. A large French prospective cohort of HIV-infected patients: the Nadis Cohort. HIV Med 2009; 10: 504-511.
8. Saune K, Delaugerre C, Raymond S etal. Analytical sensitivity of three real-time PCR assays for measuring subtype B HIV-1 RNA. J Clin Virol 2013; 57: 80-83.
9. Bonora S, Nicastri E, Calcagno A etal. Ultrasensitive assessment of residual HIV viraemia in HAART-treated patients with persistently undetectable plasma HIV-RNA: a cross-sectional evaluation. J Med Virol 2009; 81: 400-405.
10. Haim-Boukobza S, Morand-Joubert L, Flandre P etal. Higher efficacy of nevirapine than efavirenz to achieve HIV-1 plasma viral load below 1 copy/ml. AIDS 2011; 25: 341-344.
11. Benzie AA, Bansi LK, Sabin CA etal. Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures. AIDS 2007; 21: 1423-1430.
12. Rosenblum M, Deeks SG, van der Laan M, Bangsberg DR. The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy. PLoS ONE 2009; 4: e7196.
13. Lima VD, Bangsberg DR, Harrigan PR etal. Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. J Acquir Immune Defic Syndr 2010; 55: 460-465.
14. Carlos Martin J, Castilla J, Lopez M, Arranz R, Gonzalez-Lahoz J, Soriano V. Impact of chronic hepatitis C on HIV-1 disease progression. HIV Clin Trials 2004; 5: 125-131.
15. Cooper CL, Mills E. Comparison of first antiretroviral treatment duration and outcome in HIV, HIV-HBV and HIV-HCV infection. Int J STD AIDS 2007; 18: 546-550.
16. Gandhi RT, Deeks SG. Plasma HIV-1 RNA levels during antiretroviral therapy: how low is low enough? Clin Infect Dis 2012; 54: 733-775.
17. Palmer S, Wiegand AP, Maldarelli F etal. New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 2003; 41: 4531-4536.