Systemic delivery of fusogenic membrane glycoprotein-expressing neural stem cells to selectively kill tumor cells

Molecular Therapy

Volumn 21, Issue 8, 2013, Pages 1621-1630

  Zhu, Detu ^a,b   Lam, Dang Hoang ^a,b   Purwanti, Yovita Ida ^a,b   Goh, Sal Lee ^a   Wu, Chunxiao ^b   Zeng, Jieming ^b   Fan, Weimin ^c   Wang, Shu ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FUSOGENIC MEMBRANE GLYCOPROTEIN; MUTANT PROTEIN; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSENSOR; BREAST CANCER; CANCER GENE THERAPY; CELL KILLING; CELL PH; CONTROLLED STUDY; EXTRACELLULAR PH; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MOUSE; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PH SENSOR; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; STEM CELL GENE THERAPY; SUICIDE GENE; SYNCYTIUM; TROPISM; VESICULAR STOMATITIS VIRUS;

MUS; SIMPLEXVIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CELL- AND TISSUE-BASED THERAPY; DISEASE MODELS, ANIMAL; FEMALE; GENES, TRANSGENIC, SUICIDE; GENETIC THERAPY; GIANT CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INDUCED PLURIPOTENT STEM CELLS; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM METASTASIS; NEOPLASMS; NEURAL STEM CELLS; VIRAL ENVELOPE PROTEINS;

EID: 84881310534     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.123     Document Type: Article

References (38)

1. Cihova, M, Altanerova, V and Altaner, C (2011). Stem cell based cancer gene therapy. Mol Pharm 8: 1480-1487.
2. Binello, E and Germano, IM (2012). Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro-oncology 14: 256-265.
3. Shah, K (2012). Mesenchymal stem cells engineered for cancer therapy. Adv Drug Deliv Rev 64: 739-748.
4. Karnoub, AE, Dash, AB, Vo, AP, Sullivan, A, Brooks, MW, Bell, GW et al. (2007). Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563.
5. Galderisi, U, Giordano, A and Paggi, MG (2010). The bad and the good of mesenchymal stem cells in cancer: Boosters of tumor growth and vehicles for targeted delivery of anticancer agents. World J Stem Cells 2: 5-12.
6. Klopp, AH, Gupta, A, Spaeth, E, Andreeff, M and Marini, F 3rd (2011). Concise review: Dissecting a discrepancy in the literature: Do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29: 11-19.
7. Tang, Y, Shah, K, Messerli, SM, Snyder, E, Breakefield, X and Weissleder, R (2003). In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 14: 1247-1254.
8. Aboody, KS, Bush, RA, Garcia, E, Metz, MZ, Najbauer, J, Justus, KA et al. (2006). Development of a tumor-selective approach to treat metastatic cancer. PLoS ONE 1: E23.
9. Danks, MK, Yoon, KJ, Bush, RA, Remack, JS, Wierdl, M, Tsurkan, L et al. (2007). Tumortargeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 67: 22-25.
10. Frank, RT, Edmiston, M, Kendall, SE, Najbauer, J, Cheung, CW, Kassa, T et al. (2009). Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PLoS ONE 4: E8314.
11. Zhao, Y and Wang, S (2010). Human NT2 neural precursor-derived tumor-infiltrating cells as delivery vehicles for treatment of glioblastoma. Hum Gene Ther 21: 683-694.
12. Kim, JH, Kim, JY, Kim, SU and Cho, KG (2012). Therapeutic effect of genetically modified human neural stem cells encoding cytosine deaminase on experimental glioma. Biochem Biophys Res Commun 417: 534-540.
13. Yang, J, Lam, DH, Goh, SS, Lee, EX, Zhao, Y, Tay, FC et al. (2012). Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model. Stem Cells 30: 1021-1029.
14. Zhao, D, Najbauer, J, Annala, AJ, Garcia, E, Metz, MZ, Gutova, M et al. (2012). Human neural stem cell tropism to metastatic breast cancer. Stem Cells 30: 314-325.
15. Zhao, Y, Lam, DH, Yang, J, Lin, J, Tham, CK, Ng, WH et al. (2012). Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors. Gene Ther 19: 189-200.
16. Fischer, UM, Harting, MT, Jimenez, F, Monzon-Posadas, WO, Xue, H, Savitz, SI et al. (2009). Pulmonary passage is a major obstacle for intravenous stem cell delivery: The pulmonary first-pass effect. Stem Cells Dev 18: 683-692.
17. Bateman, A, Bullough, F, Murphy, S, Emiliusen, L, Lavillette, D, Cosset, FL et al. (2000). Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth. Cancer Res 60: 1492-1497.
18. Roche, S, Bressanelli, S, Rey, FA and Gaudin, Y (2006). Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G. Science 313: 187-191.
19. Florkiewicz, RZ and Rose, JK (1984). A cell line expressing vesicular stomatitis virus glycoprotein fuses at low pH. Science 225: 721-723.
20. Lee, ES, Gao, Z and Bae, YH (2008). Recent progress in tumor pH targeting nanotechnology. J Control Release 132: 164-170.
21. Zhang, X, Lin, Y and Gillies, RJ (2010). Tumor pH and its measurement. J Nucl Med 51: 1167-1170.
22. Roche, S, Rey, FA, Gaudin, Y and Bressanelli, S (2007). Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science 315: 843-848.
23. Roche, S, Albertini, AA, Lepault, J, Bressanelli, S and Gaudin, Y (2008). Structures of vesicular stomatitis virus glycoprotein: Membrane fusion revisited. Cell Mol Life Sci 65: 1716-1728.
24. Higuchi, H, Bronk, SF, Bateman, A, Harrington, K, Vile, RG and Gores, GJ (2000). Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: Implications for gene therapy. Cancer Res 60: 6396-6402.
25. Linardakis, E, Bateman, A, Phan, V, Ahmed, A, Gough, M, Olivier, K et al. (2002). Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion. Cancer Res 62: 5495-5504.
26. Errington, F, Bateman, A, Kottke, T, Thompson, J, Harrington, K, Merrick, A et al. (2006). Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy. Clin Cancer Res 12: 1333-1341.
27. Temchura, VV, Tenbusch, M, Nchinda, G, Nabi, G, Tippler, B, Zelenyuk, M et al. (2008). Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus. Vaccine 26: 3662-3672.
28. Mao, CP, Hung, CF, Kang, TH, He, L, Tsai, YC, Wu, CY et al. (2010). Combined administration with DNA encoding vesicular stomatitis virus G protein enhances DNA vaccine potency. J Virol 84: 2331-2339.
29. Bateman, AR, Harrington, KJ, Kottke, T, Ahmed, A, Melcher, AA, Gough, MJ et al. (2002). Viral fusogenic membrane glycoproteins kill solid tumor cells by nonapoptotic mechanisms that promote cross presentation of tumor antigens by dendritic cells. Cancer Res 62: 6566-6578.
30. Diaz, RM, Bateman, A, Emiliusen, L, Fielding, A, Trono, D, Russell, SJ et al. (2000). A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy. Gene Ther 7: 1656-1663.
31. Boulaire, J, Balani, P and Wang, S (2009). Transcriptional targeting to brain cells: Engineering cell type-specific promoter containing cassettes for enhanced transgene expression. Adv Drug Deliv Rev 61: 589-602.
32. Lei, Y, Lee, CL, Joo, KI, Zarzar, J, Liu, Y, Dai, B et al. (2011). Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases. Mol Ther 19: 942-950.
33. Heimpel, AM and Buchanan, LK (1967). Human feeding tests using a nuclearpolyhedrosis virus of Heliothis zea. J Invertebr Pathol 9: 55-57.
34. Lesch, HP, Makkonen, KE, Laitinen, A, Määttä, AM, Närvänen, O, Airenne, KJ et al. (2011). Requirements for baculoviruses for clinical gene therapy applications. J Invertebr Pathol 107 (suppl.): S106-S112.
35. Airenne, KJ, Hu, YC, Kost, TA, Smith, RH, Kotin, RM, Ono, C et al. (2013). Baculovirus: An insect-derived vector for diverse gene transfer applications. Mol Ther 21: 739-749.
36. Bak, XY, Yang, J and Wang, S (2010). Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy. Cancer Gene Ther 17: 721-729.
37. Zeng, J, Du, J, Zhao, Y, Palanisamy, N and Wang, S (2007). Baculoviral vectormediated transient and stable transgene expression in human embryonic stem cells. Stem Cells 25: 1055-1061.
38. Zeng, J, Du, J, Lin, J, Bak, XY, Wu, C and Wang, S (2009). High-efficiency transient transduction of human embryonic stem cell-derived neurons with baculoviral vectors. Mol Ther 17: 1585-1593.