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Volumn 263, Issue 5, 2013, Pages 385-391

The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk - A European multicentre study on treatment-resistant major depressive disorder

Author keywords

CYP1A2; CYP2C19; CYP2C9; CYP2D6; Cytochrome genes; Pharmocogenetics; Suicidality

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; GENOMIC DNA;

EID: 84881310365     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-012-0375-y     Document Type: Article
Times cited : (16)

References (45)
  • 1
    • 84881314570 scopus 로고    scopus 로고
    • WHO Accessed 17th March 2012
    • WHO (2012) Programmes and projects, mental health. http://www.who.int/ mental-health/management/depression/definition/en/ Accessed 17th March 2012
    • (2012) Programmes and Projects, Mental Health
  • 6
    • 84881312305 scopus 로고    scopus 로고
    • Eurostat: Causes of death in the EU(2006) EUROSTAT Accessed 12th January 2012
    • Eurostat: Causes of death in the EU(2006) EUROSTAT. Statistics in focus - Population and social conditions. 10:1-11. http://epp.eurostat.ec.europa.eu/ cache/ITY-OFFPUB/KS-NK-06-010/EN/KS-NK-06-010-EN.PDF. Accessed 12th January 2012
    • Statistics in Focus - Population and Social Conditions , vol.10 , pp. 1-11
  • 7
    • 64349104074 scopus 로고    scopus 로고
    • Suicide
    • 19376453 10.1016/S0140-6736(09)60372-X
    • Hawton K, van Heeringen K (2009) Suicide. Lancet 373(9672):1372-1381
    • (2009) Lancet , vol.373 , Issue.9672 , pp. 1372-1381
    • Hawton, K.1    Van Heeringen, K.2
  • 8
    • 0030890187 scopus 로고    scopus 로고
    • Suicide as an outcome for mental disorders. A meta-analysis
    • Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders: a meta-analysis. Br J Psychiatry 170:205-228 (Pubitemid 27117683)
    • (1997) British Journal of Psychiatry , vol.170 , Issue.MAR. , pp. 205-228
    • Harris, E.C.1    Barraclough, B.2
  • 11
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • DOI 10.1016/j.tips.2004.02.007, PII S0165614704000550
    • Ingelman-Sundberg M (2004) Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 25(4):193-200 (Pubitemid 38519910)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.4 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 12
    • 77952301353 scopus 로고    scopus 로고
    • Pharmacogenetic biomarkers as tools for improved drug therapy; Emphasis on the cytochrome P450 system
    • 20494117 10.1016/j.bbrc.2010.02.162 1:CAS:528:DC%2BC3cXmsVGlsb8%3D (Review)
    • Ingelman-Sundberg M, Sim SC (2010) Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system. Biochem Biophys Res Commun 396(1):90 (Review)
    • (2010) Biochem Biophys Res Commun , vol.396 , Issue.1 , pp. 90
    • Ingelman-Sundberg, M.1    Sim, S.C.2
  • 13
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • DOI 10.1038/sj.mp.4001494
    • Kirchheiner J, Nickchen K, Bauer M, Wong ML, Licinio J, Roots I, Brockmöller J (2004) Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry 9(5):442-473 (Review) (Pubitemid 38903502)
    • (2004) Molecular Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.-L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 14
    • 47749098274 scopus 로고    scopus 로고
    • How can we realize the promise of personalized antidepressant medicines?
    • 18628772 10.1038/nrn2453 1:CAS:528:DC%2BD1cXoslens7o%3D
    • Holsboer F (2008) How can we realize the promise of personalized antidepressant medicines? Nat Rev Neurosci 9(8):638-646
    • (2008) Nat Rev Neurosci , vol.9 , Issue.8 , pp. 638-646
    • Holsboer, F.1
  • 15
    • 70450203616 scopus 로고    scopus 로고
    • The role of pharmacogenetics in the treatment of depression and anxiety disorders
    • 19738481 10.1097/YIC.0b013e3283306a2f (Review)
    • Schosser A, Kasper S (2009) The role of pharmacogenetics in the treatment of depression and anxiety disorders. Int Clin Psychopharmacol 24(6):277-288 (Review)
    • (2009) Int Clin Psychopharmacol , vol.24 , Issue.6 , pp. 277-288
    • Schosser, A.1    Kasper, S.2
  • 16
    • 80051888635 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism
    • 21736534 10.1517/17425255.2011.597740 1:CAS:528:DC%2BC3MXhtVWmsLrK (Review)
    • Porcelli S, Fabbri C, Spina E, Serretti A, De Ronchi D (2011) Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism. Expert Opin Drug Metab Toxicol 7(9):1101-1115 (Review)
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , Issue.9 , pp. 1101-1115
    • Porcelli, S.1    Fabbri, C.2    Spina, E.3    Serretti, A.4    De Ronchi, D.5
  • 17
    • 77956941401 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressive treatment
    • 20047055 10.1007/s00406-009-0091-4
    • Zobel A, Maier W (2010) Pharmacogenetics of antidepressive treatment. Eur Arch Psychiatry Clin Neurosci 260(5):407-417
    • (2010) Eur Arch Psychiatry Clin Neurosci , vol.260 , Issue.5 , pp. 407-417
    • Zobel, A.1    Maier, W.2
  • 20
    • 79955796641 scopus 로고    scopus 로고
    • Pharmacogenomics of antidepressant treatment effects
    • 21485747
    • Licinio J, Wong ML (2011) Pharmacogenomics of antidepressant treatment effects. Dialogues Clin Neurosci 13(1):63-71
    • (2011) Dialogues Clin Neurosci , vol.13 , Issue.1 , pp. 63-71
    • Licinio, J.1    Wong, M.L.2
  • 22
    • 44849119612 scopus 로고    scopus 로고
    • Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample
    • DOI 10.1371/journal.pone.0001872
    • Peters EJ, Slager SL, Kraft JB, Jenkins GD, Reinalda MS, McGrath PJ, Hamilton SP (2008) Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample. PLoS ONE 3(4):e1872 (Pubitemid 351943829)
    • (2008) PLoS ONE , vol.3 , Issue.4
    • Peters, E.J.1    Slager, S.L.2    Kraft, J.B.3    Jenkins, G.D.4    Reinalda, M.S.5    McGrath, P.J.6    Hamilton, S.P.7
  • 24
  • 25
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C (2007) Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116(3):496-526 (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 26
    • 33645501005 scopus 로고    scopus 로고
    • Pharmacogenomics and antidepressant drugs
    • 16581694 10.1080/07853890600551045 1:CAS:528:DC%2BD28XjtVOisr0%3D
    • Binder EB, Holsboer F (2006) Pharmacogenomics and antidepressant drugs. Ann Med 38:82-94
    • (2006) Ann Med , vol.38 , pp. 82-94
    • Binder, E.B.1    Holsboer, F.2
  • 27
    • 48549093980 scopus 로고    scopus 로고
    • Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: An update
    • 18691982 10.1016/S0149-2918(08)80047-1 1:CAS:528:DC%2BD1MXltVyitL8%3D
    • Spina E, Santoro V, D'Arrigo C (2008) Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update. Clin Ther 30:1206-1227
    • (2008) Clin Ther , vol.30 , pp. 1206-1227
    • Spina, E.1    Santoro, V.2    D'Arrigo, C.3
  • 28
    • 84861481592 scopus 로고    scopus 로고
    • European group for the study of resistant depression (GSRD) - Where have we gone so far: Review of clinical and genetic findings
    • 22464339 10.1016/j.euroneuro.2012.02.006 1:CAS:528:DC%2BC38XltVanurc%3D
    • Schosser A, Serretti A, Souery D, Mendlewicz J, Zohar J, Montgomery S, Kasper S (2012) European group for the study of resistant depression (GSRD) - Where have we gone so far: review of clinical and genetic findings. Eur Neuropsychopharmacol 22(7):453-468
    • (2012) Eur Neuropsychopharmacol , vol.22 , Issue.7 , pp. 453-468
    • Schosser, A.1    Serretti, A.2    Souery, D.3    Mendlewicz, J.4    Zohar, J.5    Montgomery, S.6    Kasper, S.7
  • 30
    • 72949151592 scopus 로고
    • A rating scale for depression
    • 14399272 10.1136/jnnp.23.1.56 1:STN:280:DyaF3c7ltFyksw%3D%3D
    • Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
    • (1960) J Neurol Neurosurg Psychiatry , vol.23 , pp. 56-62
    • Hamilton, M.1
  • 31
    • 0035829361 scopus 로고    scopus 로고
    • Controlling the false discovery rate in behavior genetics research
    • DOI 10.1016/S0166-4328(01)00297-2, PII S0166432801002972
    • Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I (2001) Controlling the false discovery rate in behaviour genetics research. Behav Brain Res 125:279-284 (Pubitemid 33000466)
    • (2001) Behavioural Brain Research , vol.125 , Issue.1-2 , pp. 279-284
    • Benjamini, Y.1    Drai, D.2    Elmer, G.3    Kafkafi, N.4    Golani, I.5
  • 32
    • 0035238631 scopus 로고    scopus 로고
    • What can psychiatric genetics offer suicidology?
    • 11727895 1:STN:280:DC%2BD3MnotFersA%3D%3D
    • McGuffin P, Marusic A, Farmer A (2001) What can psychiatric genetics offer suicidology? Crisis 22(2):61-65
    • (2001) Crisis , vol.22 , Issue.2 , pp. 61-65
    • McGuffin, P.1    Marusic, A.2    Farmer, A.3
  • 33
    • 33645518693 scopus 로고    scopus 로고
    • Genetics of suicide
    • 16462816 10.1038/sj.mp.4001803 1:CAS:528:DC%2BD28XivFSmu7k%3D
    • Bondy B, Buettner A, Zill P (2006) Genetics of suicide. Mol Psychiatry 11(4):336-351
    • (2006) Mol Psychiatry , vol.11 , Issue.4 , pp. 336-351
    • Bondy, B.1    Buettner, A.2    Zill, P.3
  • 34
    • 13244249720 scopus 로고    scopus 로고
    • Family genetic studies, suicide, and suicidal behaviour
    • Brent DA, Mann JJ (2006) Family genetic studies, suicide, and suicidal behaviour. Am J Med Genet C Semin Med Genet 133C(1):13-24
    • (2006) Am J Med Genet C Semin Med Genet , vol.133 , Issue.1 , pp. 13-24
    • Brent, D.A.1    Mann, J.J.2
  • 36
    • 0035938897 scopus 로고    scopus 로고
    • Depression, suicide, and the national service framework
    • Davies S, Naik PC, Lee AS (2001) Depression, suicide, and the national service framework. BMJ 322(7301):1500-1501 (Pubitemid 32588342)
    • (2001) British Medical Journal , vol.322 , Issue.7301 , pp. 1500-1501
    • Davies, S.1    Naik, P.C.2    Lee, A.S.3
  • 38
    • 77955865554 scopus 로고    scopus 로고
    • High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases
    • 19907421 10.1038/clpt.2009.216 1:CAS:528:DC%2BC3cXhtVCntbfL
    • Zackrisson AL, Lindblom B, Ahlner J (2010) High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases. Clin Pharmacol Ther 88(3):354-359
    • (2010) Clin Pharmacol Ther , vol.88 , Issue.3 , pp. 354-359
    • Zackrisson, A.L.1    Lindblom, B.2    Ahlner, J.3
  • 41
    • 1242269894 scopus 로고    scopus 로고
    • Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: Ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
    • DOI 10.1007/s00228-003-0701-4
    • Kawanishi C, Lundgren S, Agren H, Bertilsson L (2004) Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study. Eur J Clin Pharmacol 59(11):803-807 (Pubitemid 38221657)
    • (2004) European Journal of Clinical Pharmacology , vol.59 , Issue.11 , pp. 803-807
    • Kawanishi, C.1    Lundgren, S.2    Agren, H.3    Bertilsson, L.4
  • 42
    • 42249096306 scopus 로고    scopus 로고
    • Stress, Genes and the Biology of Suicidal Behavior
    • DOI 10.1016/j.psc.2008.01.005, PII S0193953X0800018X
    • Currier D, Mann JJ (2008) Stress, genes and the biology of suicidal behavior. Psychiatr Clin N Am 31(2):247-269 (Review) (Pubitemid 351551422)
    • (2008) Psychiatric Clinics of North America , vol.31 , Issue.2 , pp. 247-269
    • Currier, D.1    Mann, J.J.2
  • 43
    • 11244334138 scopus 로고    scopus 로고
    • Value of measuring suicidal intent in the assessment of people attending hospital following self-poisoning or self-injury
    • DOI 10.1192/bjp.186.1.60
    • Harriss L, Hawton K, Zahl D (2005) Value of measuring suicidal intent in the assessment of people attending hospital following self-poisoning or self-injury. Br J Psychiatry 186:60-66 (Pubitemid 40070545)
    • (2005) British Journal of Psychiatry , vol.186 , Issue.JAN. , pp. 60-66
    • Harriss, L.1    Hawton, K.2    Zahl, D.3


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