Formulation and in vitro characterization of intranasal mucoadhesive microspheres of lamotrigine using chitosan by gluteraldehyde cross linking

International Journal of Pharma and Bio Sciences

Volumn 4, Issue 3, 2013, Pages

  Dave, Kapilesh ^a,b   Purohit, Suresh ^c  

^a JNU   (India)

^b Mandsaur Institute of Pharmacy   (India)

^c BANARAS HINDU UNIVERSITY   (India)

Author keywords

Antiepileptic; Evaporation; Lamotrigine; Microsphere; Solvent

Indexed keywords

CHITOSAN; EXCIPIENT; GLUTARALDEHYDE; LAMOTRIGINE; MICROSPHERE; POLYMER;

ARTICLE; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; EMULSION; ENCAPSULATION; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MUCOADHESION; PARTICLE SIZE; PROCESS OPTIMIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCANNING ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY;

EID: 84881290719     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Yie W. Chein, Novel drug delivery system. 2nd Edn, Vol 50, Marcel Dekker Inc. New York, 229-266 (2005).
2. David J. Begley, Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacology & Therapeutics, 104: 29-45 (2004).
3. In Koo Chun, Yeon Hong Lee, Kyung Eun Lee, and Hye Sun Gwak, Design and Evaluation of Levodopa Methyl Ester Intranasal Delivery Systems. Journal of Parkinson's Disease, 1 (1): 101-107 (2011).
4. Sakane T, Akizuki M, Yoshida M, Yamashita S, Nadai T, Hashida M and Sezaki H, Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity. J Pharm Pharmacol., 43 (6): 449-51 (1991).
5. Dyer AM, Hinchcliffe M, Watts P, Castile J, Jabbal-Gill I, Nankervis R, Smith A and Illum L, Nasal delivery of insulin using novel chitosan based formulations: a comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles. Pharm Res., 19 (7): 998-1008 (2002).
6. Henry R. Costantino, Lisbeth Illum, Gordon Brandt, Paul H. Johnson and Steven C. Quay, Intranasal delivery: Physicochemical and therapeutic aspects. Int. J Pharma. 337: 1-24 (2007).
7. Lan Tan, Jin-Tai Yu and Hua-Shi Guan, Intranasal anticonvulsive treatment: A prospective management of intractable epilepsy, Medical Hypotheses, 71: 542-545 (2008).
8. Daniel P. Wermeling, Intranasal delivery of antiepileptic medications for treatment of seizures. Neurotherapeutics, 6 (2): 352-358 (2009).
9. Drug Bank of Lamotrigine URL: http://www.drugbank.ca/drugs/DB00555
10. E. Gavini, A. B. Hegge, G. Rassu, V. Sanna, C. Testa, G. Pirisino, J. Karlsen and P. Giunchedi, Nasal administration of Carbamazepine using chitosan microspheres: In vitro/in vivo studies. Int. J. Pharma., 307 (1): 9-15 (2006).
11. Government of India. Ministry of health and family welfare. Indian Pharmacopoeia, Vol 2nd, The controller of publication, New Delhi, 667-669 (2007).
12. R. Dinarvand, S. Mahmoodi, E. Farboud, Effect of process variables on particle size of gelatin microspheres containing lactic acid, Pharm. Dev. Technol. 9 (3) (2004) 291-299.
13. Jag Mohan, Organic Spectroscopy: Principles and Applications. 2nd Edn, Narosa Publishing House, Kolkata, India (2008).
14. C. Dubernet, Thermoanalysis of microspheres. Thermochimica Acta, 248: 259-269 (1995).
15. O. I. Corrigan, Thermal analysis of spray dried products. Thermochimica Acta, 248: 248-258 (1995).
16. Cevher E, Orhan Z, Mulazimoglu L, Sensoy D, Alper M, Yildiz A, Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant staphylococcus aureus with prepared microspheres. Int J Pharm, 317: 127-35 (2006).
17. Mathew ST, Gayathri Devi S, Sandhya KV, Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration. AAPS Pharm Sci Tech, 8(1): Article 14:E1-9 (2007).
18. Trivedi P, Verma A, Garud N, Preparation and characterization of aceclofenac microspheres. Asian J Pharm,2:110-5 (2008).
19. Srivastava AK, Ridhurkar DN, Wadhwa S, Floating microspheres of cimetidine: formulation, characterization and in vivo evaluation. Acta Pharm, 55:277-85 (2005).
20. M.D.A. El-Humeed, I. W. K&away, Preparation and in vitro characterization of mucoadhesive polymeric microspheres as intra-nasal delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 44: 53-60 (1997).
21. S.B. Patil, K.K. Sawant, Chitosan microspheres as a delivery system for nasal insufflations. Colloids and Surfaces B: Biointerfaces, 84: 384-389 (2011).
22. Prahsant L. Pingale and Ravindra R.P., Effect of piper nigrum on in-vitro release of isoniazid from oral microspheres. International Journal of Pharma and Bio Sciences, 4 (1): 1027-1036 (2013).