Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers

Protein Science

Volumn 22, Issue 8, 2013, Pages 1100-1108

  Deshpande, Ashlesha ^a   Putcha, Balananda Dhurjati Kumar ^a   Kuruganti, Srilalitha ^a   Walter, Mark R ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Cytokine; Engineered FC; Heterodimer; IFNAR1; IFNAR2; Interferon; Surface plasmon resonance

Indexed keywords

ALPHA2A INTERFERON; HETERODIMER; HYBRID PROTEIN; INTERFERON RECEPTOR; INTERFERON RECEPTOR 1; INTERFERON RECEPTOR 2; MONOMER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOLOGICAL ACTIVITY; CELL GROWTH; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; HUMAN; IMMUNITY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; VALIDATION STUDY;

CYTOKINE; ENGINEERED FC; HETERODIMER; IFNAR1; IFNAR2; INTERFERON; SURFACE PLASMON RESONANCE;

IMMUNOGLOBULIN FC FRAGMENTS; INTERFERON-ALPHA; KINETICS; LIGANDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTOR, INTERFERON ALPHA-BETA; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE;

EID: 84881272936     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2285     Document Type: Article

References (38)

1. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O'Mahony L, Palomares O, Rhyner C, Ouaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA (2011) Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol 127:701-721, e1-e70.
2. Commins SP, Borish L, Steinke JW (2010) Immunologic messenger molecules: cytokines, interferons, and chemokines. J Allergy Clin Immunol 125:S53-S72.
3. Bublil EM, Yarden Y (2007) The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 19:124-134.
4. Hynes NE, Macdonald G (2009) ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 21: 177-184.
5. LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell 132:259-272.
6. Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC (2011) Structural linkage between ligand discrimination and receptor activation by Type I interferons. Cell 146:621-632.
7. Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR (2012) Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci USA 109: 12704-12709.
8. de Vos AM, Ultsch M, Kossiakoff AA (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306-312.
9. Wu Z, Johnson KW, Choi Y, Ciardelli TL (1995) Ligand binding analysis of soluble interleukin-2 receptor complexes by surface plasmon resonance. J Biol Chem 270: 16045-16051.
10. Chao H, Houston ME Jr, Grothe S, Kay CM, O'Connor-McCourt M, Irvin RT, Hodges RS (1996) Kinetic study on the formation of a de novo designed heterodimeric coiled-coil: use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains. Biochemistry 35:12175-12185.
11. Lata S, Piehler J (2006) Synthesis of a multivalent chelator lipid for stably tethering histidine-tagged proteins onto membranes. Nat Protoc 1:2104-2109.
12. Lata S, Piehler J (2005) Stable and functional immobilization of histidine-tagged proteins via multivalent chelator headgroups on a molecular poly(ethylene glycol) brush. Anal Chem 77:1096-1105.
13. Czajkowsky DM, Hu J, Shao Z, Pleass RJ (2012) Fcfusion proteins: new developments and future perspectives. EMBO Mol Med 4:1015-1028.
14. Ridgway JB, Presta LG, Carter P (1996) 'Knobs-intoholes' engineering of antibody CH3 domains for heavy chain heterodimerization. Protein Eng 9:617-621.
15. Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, Stark GR (2007) Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 6:975-990.
16. Uze G, Schreiber G, Piehler J, Pellegrini S (2007) The receptor of the type I interferon family. Curr Top Microbiol Immunol 316:71-95.
17. Platanias LC (2005) Mechanisms of type-I-and type-IIinterferon-mediated signalling. Nat Rev Immunol 5: 375-386.
18. Kalie E, Jaitin DA, Podoplelova Y, Piehler J, Schreiber G (2008) The stability of the ternary interferonreceptor complex rather than the affinity to the individual subunits dictates differential biological activities. J Biol Chem 283:32925-32936.
19. Jaks E, Gavutis M, Uze G, Martal J, Piehler J (2007) Differential receptor subunit affinities of type I interferons govern differential signal activation. J Mol Biol 366:525-539.
20. Cajean-Feroldi C, Nosal F, Nardeux PC, Gallet X, Guymarho J, Baychelier F, Sempe P, Tovey MG, Escary JL, Eid P (2004) Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity. Biochemistry 43:12498-12512.
21. Piehler J, Schreiber G (1999) Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2. J Mol Biol 289:57-67.
22. Lamken P, Lata S, Gavutis M, Piehler J (2004) Ligandinduced assembling of the type I interferon receptor on supported lipid bilayers. J Mol Biol 341:303-318.
23. Harris LJ, Larson SB, Hasel KW, McPherson A (1997) Refined structure of an intact IgG2a monoclonal antibody. Biochemistry 36:1581-1597.
24. Arndt KM, Pelletier JN, Muller KM (2002) Comparison of in vivo selection and rational design of heterodimeric coiled coils. Structure 10:1235-1248.
25. Glover JN, Harrison SC (1995) Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373:257-261.
26. Manneberg M, Friedlein A, Kurth H, Lahm HW, Fountoulakis M (1994) Structural analysis and localization of the carbohydrate moieties of a soluble human interferon gamma receptor produced in baculovirusinfected insect cells. Protein Sci 3:30-38.
27. Lewerenz M, Mogensen KE, Uze G (1998) Shared receptor components but distinct complexes for alpha and beta interferons. J Mol Biol 282:585-599.
28. Lazareno S, Birdsall NJ (1993) Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br J Pharmacol 109:1110-1119.
29. Ronnblom L, Alm GV, Eloranta ML (2011) The type I interferon system in the development of lupus. Semin Immunol 23:113-121.
30. Niewold TB, Hua J, Lehman TJ, Harley JB, Crow MK (2007) High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 8:492-502.
31. Ronnblom L, Alm GV, Eloranta ML (2009) Type I interferon and lupus. Curr Opin Rheumatol 21:471-477.
32. Yao Y, Richman L, Higgs BW, Morehouse CA, de los Reyes M, Brohawn P, Zhang J, White B, Coyle AJ, Kiener PA, Jallal B (2009) Neutralization of interferonalpha/ beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 60:1785-1796.
33. Diana J, Simoni Y, Furio L, Beaudoin L, Agerberth B, Barrat F, Lehuen A (2013) Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med 19:65-73.
34. Pestka S (2007) The interferons: 50 years after their discovery, there is much more to learn. J Biol Chem 282:20047-20051.
35. Kotenko SV (2011) IFN-lambdas. Curr Opin Immunol 23:583-590.
36. Studier FW (2005) Protein production by autoinduction in high density shaking cultures. Protein Expr Purif 41:207-234.
37. Konarev PV, Volkov VV, Sokolov AV, Koch MHJ, Svergun DI (2003) PRIMUS: aWindows PC-based systemfor smallangle scattering data analysis. J Appl Cryst 36:1277-1282.
38. Svergun DI (1999) Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys J 76:2879-2886.