Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-cell lung cancer cell line

Acta Biochimica et Biophysica Sinica

Volumn 45, Issue 2, 2013, Pages 115-122

  Li, Shuhai ^a   Tian, Hui ^a   Yue, Weiming ^a   Li, Lin ^a   Gao, Cun ^a   Si, Libo ^a   Li, Wenjun ^a   Hu, Wensi ^a   Qi, Lei ^a   Lu, Ming ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Angiogenesis; Metastasis associated protein 1; Non small cell lung cancer; RNA interference

Indexed keywords

HISTONE DEACETYLASE; MTA1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; CELL MOTION; DOWN REGULATION; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOPHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; HISTONE DEACETYLASES; HUMANS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; REPRESSOR PROTEINS;

MLCS; MLOWN;

EID: 84881262246     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gms113     Document Type: Article

References (39)

1. Brognard J, Clark AS, Ni Y and Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001, 61: 3986-3997.
2. Ren H, Tang X, Lee JJ, Feng L, Everett AD, Hong WK and Khuri FR, et al. Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer. J Clin Oncol 2004, 22: 3230-3237.
3. Hoffman PC, Mauer AM and Vokes EE. Lung cancer. Lancet 2000, 355: 479-485.
4. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006, 12: 895-904.
5. Toh Y and Nicolson GL. The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clin Exp Metastasis 2009, 26: 215-227.
6. Nawa A, Nishimori K, Lin P, Maki Y, Moue K, Sawada H and Toh Y, et al. Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J Cell Biochem 2000, 79: 202-212.
7. Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M and Vadlamudi RK, et al. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol 2001, 3: 30-37.
8. Nicolson GL, Nawa A, Toh Y, Taniguchi S, Nishimori K and Moustafa A. Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis 2003, 20: 19-24.
9. Hofer MD, Menke A, Genze F, Gierschik P and Giehl K. Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells. Br J Cancer 2004, 90: 455-462.
10. Qian H, Lu N, Xue L, Liang X, Zhang X, Fu M and Xie Y, et al. Reduced MTA1 expression by RNAi inhibits in vitro invasion and migration of esophageal squamous cell carcinoma cell line. Clin Exp Metastasis 2005, 22: 653-662.
11. Zhu X, Guo Y, Li X, Ding Y and Chen L. Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer. J Thorac Oncol 2010, 5: 1159-1166.
12. Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25: 402-408.
13. Li L, Tian H, Yue W, Zhu F, Li S and Li W. Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo. J Cell Physiol 2011, 226: 1860-1867.
14. Liang CC, Park AY and Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007, 2: 329-333.
15. Bae CH, Chen SM, Lee HM, Song SY and Kim YD. The effect of doxycycline on PMA-induced MUC5B expression via MMP-9 and p38 in NCI-H292 cells. Clin Exp Otorhinolaryngol 2011, 4: 177-183.
16. Wang Z, Banerjee S, Kong D, Li Y and Sarkar FH. Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells. Cancer Res 2007, 67: 8293-8300.
17. Sidransky D. Emerging molecular markers of cancer. Nat Rev Cancer 2002, 2: 210-219.
18. Kumar R, Wang RA and Bagheri-Yarmand R. Emerging roles of MTA family members in human cancers. Semin Oncol 2003, 30: 30-37.
19. Fearon ER. Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer. Cancer Cell 2003, 3: 307-310.
20. Manavathi B and Kumar R. Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem 2007, 282: 1529-1533.
21. Singh RR and Kumar R. MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer. J Mammary Gland Biol Neoplasia 2007, 12: 115-125.
22. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H and Balasenthil S, et al. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci USA 2006, 103: 6670-6675.
23. Gururaj AE, Holm C, Landberg G and Kumar R. Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Cell Cycle 2006, 5: 1407-1410.
24. Jang KS, Paik SS, Chung H, Oh YH and Kong G. MTA1 overexpression correlates significantly with tumor grade and angiogenesis in human breast cancers. Cancer Sci 2006, 97: 374-379.
25. Ryu SH, Chung YH, Lee H, Kim JA, Shin HD, Min HJ and Seo DD, et al. Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma. Hepatology 2008, 47: 929-936.
26. Miyake K, Yoshizumi T, Imura S, Sugimoto K, Batmunkh E, Kanemura H and Morine Y, et al. Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation. Pancreas 2008, 36: 1-9.
27. Yoo YG, Na TY, Seo HW, Seong JK, Park CK, Shin YK and Lee MO. Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 2008, 27: 3405-3413.
28. Kai L, Wang J, Ivanovic M, Chung YT, Laskin WB, Schulze-Hoepfner F and Mirochnik Y, et al. Targeting prostate cancer angiogenesis through metastasis-associated protein 1 (MTA1). Prostate 2011, 71: 268-280.
29. Yoo YG, Kong G and Lee MO. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J 2006, 25: 1231-1241.
30. Moon HE, Cheon H, Chun KH, Lee SK, Kim YS, Jung BK and Park JA, et al. Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Oncol Rep 2006, 16: 929-935.
31. Li SH, Tian H, Yue WM, Li L, Li WJ, Chen ZT and Hu WS, et al. Overexpression of metastasis-associated protein 1 is significantly correlated with tumor angiogenesis and poor survival in patients with early stage nonsmall cell lung cancer. Ann Surg Oncol 2011, 18: 2048-2056.
32. Zhu X, Zhang X, Wang H, Song Q, Zhang G, Yang L and Geng J, et al. MTA1 gene silencing inhibits invasion and alters the microRNA expression profile of human lung cancer cells. Oncol Rep 2012, 28: 218-224.
33. Littlepage LE, Sternlicht MD, Rougier N, Phillips J, Gallo E, Yu Y and Williams K, et al. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res 2010, 70: 2224-2234.
34. Choi JY, Jang YS, Min SY and Song JY. Overexpression of MMP-9 and HIF-1a in breast cancer cells under hypoxic conditions. J Breast Cancer 2011, 14: 88-95.
35. Yan C, Wang H, Toh Y and Boyd DD. Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation. J Biol Chem 2003, 278: 2309-2316.
36. Li JR, Li MQ, Bao JT and Li JZ. Correlation between expression of metastasis-associated gene 1 and matrix metalloproteinase 9 and invasion and metastasis of breast cancer. Zhonghua Yi Xue Za Zhi 2008, 88: 2278-2280.
37. Jiang Q, Zhang H and Zhang P. ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, cyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro. J Exp Clin Cancer Res 2011, 30: 60-70.
38. Shijubo N, Kojima H, Nagata M, Ohchi T, Suzuki A, Abe S and Sato N. Tumor angiogenesis of non-small cell lung cancer. Microsc Res Tech 2003, 60: 186-198.
39. D'Amico TA. Angiogenesis in non-small cell lung cancer. Semin Thorac Cardiovasc Surg 2004, 16: 13-18.