A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization

Methods in Molecular Biology

Volumn 986, Issue , 2013, Pages 217-226

  Natoni, Alessandro ^a   O'Dwyer, Michael ^a   Santocanale, Corrado ^a  

^a NONE

Author keywords

Cell Death; Chemotherapy; CLL; Lymph Nodes; Microenvironment; T cells

Indexed keywords

BORTEZOMIB; CYCLIN DEPENDENT KINASE INHIBITOR; FLUDARABINE; INTERLEUKIN 4; PHA 767491; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CD3 ANTIGEN; CD40 LIGAND;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CANCER CELL CULTURE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DEATH; CELL STRAIN 3T3; CHRONIC LYMPHATIC LEUKEMIA; COCULTURE; CONTROLLED STUDY; DRUG SCREENING; FIBROBLAST; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR MICROENVIRONMENT; ANIMAL; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; DRUG RESISTANCE; HAMSTER; HUMAN; LYMPH NODE; METABOLISM; METHODOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

3T3 CELLS; ANIMALS; ANTIGENS, CD3; ANTINEOPLASTIC AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL PROLIFERATION; CELLULAR MICROENVIRONMENT; CRICETINAE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPH NODES; MICE; TUMOR MICROENVIRONMENT;

MLCS; MLOWN;

EID: 84881238083     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-311-4_14     Document Type: Article

References (34)

1. Lanasa MC (2010) Novel insights into the biology of CLL. Hematology Am Soc Hematol Educ Program 2010:70-76
2. Burger JA (2011) Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2011:96-103
3. Ghia P, Chiorazzi N, Stamatopoulos K (2008) Microenvironmental in fluences in chronic lymphocytic leukaemia: the role of antigen stimulation. J Intern Med 264:549-562
4. Herishanu Y, Perez-Galan P, Liu D et al (2011) The lymph node microenvironment promotes B-cell receptor signaling. NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117:563-574
5. Jaksic O, Kardum-Skelin I, Jaksic B (2010) Chronic lymphocytic leukemia: insights from lymph nodes & bone marrow and clinical perspectives. Coll Antropol 34:309-313
6. Chiorazzi N (2007) Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells. Best Pract Res Clin Haematol 20:399-413
7. Granziero L, Ghia P, Circosta P et al (2001) Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 97: 2777-2783
8. Lampert IA, Wotherspoon A, Van Noorden S et al (1999) High expression of CD23 in the proliferation centers of chronic lymphocytic leukemia in lymph nodes and spleen. Hum Pathol 30:648-654
9. Vandewoestyne ML, Pede VC, Lambein KY et al (2011) Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles. Leukemia 25: 883-888
10. Munk Pedersen I, Reed J (2004) Microenvironmental interactions and survival of CLL B-cells. Leuk Lymphoma 45:2365-2372
11. Smit LA, Hallaert DY, Spijker R et al (2007) Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood 109:1660-1668
12. Vogler M, Butterworth M, Majid A et al (2009) Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood 113:4403-4413
13. Buggins AG, Pepper CJ (2010) The role of Bcl-2 family proteins in chronic lymphocytic leukaemia. Leuk Res 34:837-842
14. Natoni A, Murillo LS, Kliszczak AE et al (2011) Mechanisms of action of a dual Cdc7/ Cdk9 kinase inhibitor against quiescent and proliferating CLL cells. Mol Cancer Ther 10: 1624-1634
15. Burger JA, Ghia P, Rosenwald A et al (2009) The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 114:3367-3375
16. Hayden RE, Pratt G, Roberts C et al (2011) Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches. Leuk Lymphoma 53(4):537-549
17. Willimott S, Baou M, Huf S et al (2007) Separate cell culture conditions to promote proliferation or quiescent cell survival in chronic lymphocytic leukemia. Leuk Lymphoma 48:1647-1650
18. Willimott S, Baou M, Naresh K et al (2007) CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia. Br J Haematol 138:721-732
19. Neron S, Nadeau PJ, Darveau A et al (2011) Tuning of CD40-CD154 interactions in human B-lymphocyte activation: a broad array of in vitro models for a complex in vivo situation. Arch Immunol Ther Exp (Warsz) 59:25-40
20. Pepper C, Mahdi JG, Buggins AG et al (2011) Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2. Cell Prolif 44: 380-390
21. Hayden RE, Pratt G, Davies NJ et al (2009) Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14, PGJ2. Leukemia 23:292-304
22. Jak M, van Bochove GG, van Lier RA et al (2011) CD40 stimulation sensitizes CLL cells to rituximab-induced cell death. Leukemia 25:968-978
23. McCaig AM, Cosimo E, Leach MT et al (2011) Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. Br J Haematol 153(2):199-211
24. Tromp JM, Geest CR, Breij EC et al (2012) Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia. Clin Cancer Res 18:487-498
25. Jak M, van Bochove GG, Reits EA et al (2011) CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti- CD20 mAb GA101. Blood 118:5178-5188
26. Tonino SH, van Laar J, van Oers MH et al (2011) ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene 30:701-713
27. Dietrich S, Kramer OH, Hahn E et al (2012) Le flunomide induces apoptosis in fludarabineresistant and clinically refractory CLL cells. Clin Cancer Res 18:417-431
28. Hayden RE, Pratt G, Drayson MT et al (2010) Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrateand medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance. Haematologica 95:1889-1896
29. Hallaert DY, Jaspers A, van Noesel CJ et al (2008) c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches. Blood 112:5141-5149
30. Logue SE, Elgendy M, Martin SJ (2009) Expression, purification and use of recombinant annexin V for the detection of apoptotic cells. Nat Protoc 4:1383-1395
31. Baou M, Kohlhaas SL, Butterworth M et al (2010) Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells. Haematologica 95:1510-1518
32. Wright SJ, Robertson LE, O'Brien S et al (1994) The role of fludarabine in hematological malignancies. Blood Rev 8:125-134
33. Montagnoli A, Valsasina B, Croci V et al (2008) A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol 4:357-365
34. World Medical Organization (1996) Declaration of Helsinki. Br Med J 313:1448-1449