-
1
-
-
70349469565
-
Mechanisms of polycomb gene silencing: knowns and unknowns
-
Simon, J.A. and Kingston, R.E. (2009) Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell. Biol., 10, 697-708.
-
(2009)
Nat. Rev. Mol. Cell. Biol.
, vol.10
, pp. 697-708
-
-
Simon, J.A.1
Kingston, R.E.2
-
2
-
-
33745904714
-
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency
-
Almeida, A.M., Murakami, Y., Layton, D.M., Hillmen, P., Sellick, G.S., Maeda, Y., Richards, S., Patterson, S., Kotsianidis, I., Mollica, L. et al. (2006) Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Nat. Med., 12, 846-851.
-
(2006)
Nat. Med.
, vol.12
, pp. 846-851
-
-
Almeida, A.M.1
Murakami, Y.2
Layton, D.M.3
Hillmen, P.4
Sellick, G.S.5
Maeda, Y.6
Richards, S.7
Patterson, S.8
Kotsianidis, I.9
Mollica, L.10
-
3
-
-
70249117159
-
Inherited glycosylphosphatidyl inositol deficiency: a treatable CDG
-
Almeida, A., Layton, M. and Karadimitris, A. (2009) Inherited glycosylphosphatidyl inositol deficiency: a treatable CDG. Biochim. Biophys. Acta., 1792, 874-880.
-
(2009)
Biochim. Biophys. Acta.
, vol.1792
, pp. 874-880
-
-
Almeida, A.1
Layton, M.2
Karadimitris, A.3
-
4
-
-
34247229178
-
Targeted therapy for inherited GPI deficiency
-
Almeida, A.M., Murakami, Y., Baker, A., Maeda, Y., Roberts, I.A., Kinoshita, T., Layton, D.M. and Karadimitris, A. (2007) Targeted therapy for inherited GPI deficiency. N. Engl. J. Med., 356, 1641-1647.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1641-1647
-
-
Almeida, A.M.1
Murakami, Y.2
Baker, A.3
Maeda, Y.4
Roberts, I.A.5
Kinoshita, T.6
Layton, D.M.7
Karadimitris, A.8
-
5
-
-
0038676409
-
Inhibition of histone deacetylase activity by butyrate
-
Davie, J.R. (2003) Inhibition of histone deacetylase activity by butyrate. J. Nutr., 133, 2485S-2493S.
-
(2003)
J. Nutr.
, vol.133
-
-
Davie, J.R.1
-
6
-
-
84859868832
-
Modulation of the activity of sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer
-
Malek, A., Nunez, L.E., Magistri, M., Brambilla, L., Jovic, S., Carbone, G.M., Moris, F. and Catapano, C.V. (2012) Modulation of the activity of sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer. PLoS ONE, 7, e35130.
-
(2012)
PLoS ONE
, vol.7
-
-
Malek, A.1
Nunez, L.E.2
Magistri, M.3
Brambilla, L.4
Jovic, S.5
Carbone, G.M.6
Moris, F.7
Catapano, C.V.8
-
7
-
-
0025889742
-
Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo
-
Blume, S.W., Snyder, R.C., Ray, R., Thomas, S., Koller, C.A. and Miller, D.M. (1991) Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J. Clin. Invest., 88, 1613-1621.
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1613-1621
-
-
Blume, S.W.1
Snyder, R.C.2
Ray, R.3
Thomas, S.4
Koller, C.A.5
Miller, D.M.6
-
8
-
-
34249855554
-
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
-
Barceló , F., Scotta, C., Ortiz-Lombardía, M., Méndez, C., Salas, J.A. and Portugal, J. (2007) Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res., 35, 2215-2226.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 2215-2226
-
-
Barceló, F.1
Scotta, C.2
Ortiz-Lombardía, M.3
Méndez, C.4
Salas, J.A.5
Portugal, J.6
-
9
-
-
79951500297
-
CpG island chromatin: a platform for gene regulation
-
Blackledge, N.P. and Klose, R. (2011) CpG island chromatin: a platform for gene regulation. Epigenetics, 6, 147-152.
-
(2011)
Epigenetics
, vol.6
, pp. 147-152
-
-
Blackledge, N.P.1
Klose, R.2
-
10
-
-
79956330964
-
CpG islands and the regulation of transcription
-
Deaton, A.M. and Bird, A. (2011) CpG islands and the regulation of transcription. Genes Dev., 25, 1010-1022.
-
(2011)
Genes Dev.
, vol.25
, pp. 1010-1022
-
-
Deaton, A.M.1
Bird, A.2
-
11
-
-
67649669255
-
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
-
Ramirez-Carrozzi, V.R., Braas, D., Bhatt, D.M., Cheng, C.S., Hong, C., Doty, K.R., Black, J.C., Hoffmann, A., Carey, M. and Smale, S.T. (2009) A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell, 138, 114-128.
-
(2009)
Cell
, vol.138
, pp. 114-128
-
-
Ramirez-Carrozzi, V.R.1
Braas, D.2
Bhatt, D.M.3
Cheng, C.S.4
Hong, C.5
Doty, K.R.6
Black, J.C.7
Hoffmann, A.8
Carey, M.9
Smale, S.T.10
-
12
-
-
67649648237
-
Control of inducible gene expression by signal-dependent transcriptional elongation
-
Hargreaves, D.C., Horng, T. and Medzhitov, R. (2009) Control of inducible gene expression by signal-dependent transcriptional elongation. Cell, 138, 129-145.
-
(2009)
Cell
, vol.138
, pp. 129-145
-
-
Hargreaves, D.C.1
Horng, T.2
Medzhitov, R.3
-
13
-
-
78751590899
-
Silencing chromatin: comparing modes and mechanisms
-
Beisel, C. and Paro, R. (2011) Silencing chromatin: comparing modes and mechanisms. Nat. Rev. Genet., 12, 123-135.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 123-135
-
-
Beisel, C.1
Paro, R.2
-
14
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides, T. (2007) Chromatin modifications and their function. Cell, 128, 693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
15
-
-
70350500219
-
Polycomb group proteins: navigators of lineage pathways led astray in cancer
-
Bracken, A.P. and Helin, K. (2009) Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat. Rev. Cancer, 9, 773-784.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 773-784
-
-
Bracken, A.P.1
Helin, K.2
-
17
-
-
77953120646
-
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1andRNAPolymerase II to developmental regulators
-
Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jorgensen, H.F., Pereira, C.F., Leleu, M., Piccolo, F.M., Spivakov, M. et al. (2010) Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1andRNAPolymerase II to developmental regulators. Nat. Cell. Biol., 12, 618-624.
-
(2010)
Nat. Cell. Biol.
, vol.12
, pp. 618-624
-
-
Landeira, D.1
Sauer, S.2
Poot, R.3
Dvorkina, M.4
Mazzarella, L.5
Jorgensen, H.F.6
Pereira, C.F.7
Leleu, M.8
Piccolo, F.M.9
Spivakov, M.10
-
18
-
-
72249104107
-
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells
-
Shen, X., Kim, W., Fujiwara, Y., Simon, M.D., Liu, Y., Mysliwiec, M.R., Yuan, G.C., Lee, Y. and Orkin, S.H. (2009) Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell, 139, 1303-1314.
-
(2009)
Cell
, vol.139
, pp. 1303-1314
-
-
Shen, X.1
Kim, W.2
Fujiwara, Y.3
Simon, M.D.4
Liu, Y.5
Mysliwiec, M.R.6
Yuan, G.C.7
Lee, Y.8
Orkin, S.H.9
-
19
-
-
67649371461
-
DZNepis a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
-
Miranda, T.B., Cortez, C.C., Yoo, C.B., Liang, G., Abe, M., Kelly, T.K., Marquez, V.E. and Jones, P.A. (2009) DZNepis a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther., 8, 1579-1588.
-
(2009)
Mol.Cancer Ther.
, vol.8
, pp. 1579-1588
-
-
Miranda, T.B.1
Cortez, C.C.2
Yoo, C.B.3
Liang, G.4
Abe, M.5
Kelly, T.K.6
Marquez, V.E.7
Jones, P.A.8
-
20
-
-
79959590587
-
Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
-
Xie, Z., Bi, C., Cheong, L.L., Liu, S.C., Huang, G., Zhou, J., Yu, Q., Chen, C.S. and Chng, W.J. (2011) Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. PLoS ONE, 6, e21583.
-
(2011)
PLoS ONE
, vol.6
-
-
Xie, Z.1
Bi, C.2
Cheong, L.L.3
Liu, S.C.4
Huang, G.5
Zhou, J.6
Yu, Q.7
Chen, C.S.8
Chng, W.J.9
-
21
-
-
84867606040
-
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas
-
Zhang, X., Zhao, X., Fiskus, W., Lin, J., Lwin, T., Rao, R., Zhang, Y., Chan, J.C., Fu, K., Marquez, V.E. et al. (2012) Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas. Cancer Cell, 22, 506-523.
-
(2012)
Cancer Cell
, vol.22
, pp. 506-523
-
-
Zhang, X.1
Zhao, X.2
Fiskus, W.3
Lin, J.4
Lwin, T.5
Rao, R.6
Zhang, Y.7
Chan, J.C.8
Fu, K.9
Marquez, V.E.10
-
22
-
-
33847032960
-
The mammalian epigenome
-
Bernstein, B.E., Meissner, A. and Lander, E.S. (2007) The mammalian epigenome. Cell, 128, 669-681.
-
(2007)
Cell
, vol.128
, pp. 669-681
-
-
Bernstein, B.E.1
Meissner, A.2
Lander, E.S.3
-
23
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein, B.E., Mikkelsen, T.S., Xie, X., Kamal, M., Huebert, D.J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K. et al. (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell, 125, 315-326.
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
Kamal, M.4
Huebert, D.J.5
Cuff, J.6
Fry, B.7
Meissner, A.8
Wernig, M.9
Plath, K.10
-
24
-
-
33646872978
-
Chromatin signatures of pluripotent cell lines
-
Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jorgensen, H.F., John, R.M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M. et al. (2006) Chromatin signatures of pluripotent cell lines. Nat. Cell Biol., 8, 532-538.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 532-538
-
-
Azuara, V.1
Perry, P.2
Sauer, S.3
Spivakov, M.4
Jorgensen, H.F.5
John, R.M.6
Gouti, M.7
Casanova, M.8
Warnes, G.9
Merkenschlager, M.10
-
25
-
-
79953163994
-
Chromatin states in pluripotent, differentiated, and reprogrammed cells
-
Fisher, C.L. and Fisher, A.G. (2011) Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr. Opin. Genet. Dev., 21, 140-146.
-
(2011)
Curr. Opin. Genet. Dev.
, vol.21
, pp. 140-146
-
-
Fisher, C.L.1
Fisher, A.G.2
-
26
-
-
77951116072
-
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
-
Thomson, J.P., Skene, P.J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A.R., Deaton, A., Andrews, R., James, K.D. et al. (2010) CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature, 464, 1082-1086.
-
(2010)
Nature
, vol.464
, pp. 1082-1086
-
-
Thomson, J.P.1
Skene, P.J.2
Selfridge, J.3
Clouaire, T.4
Guy, J.5
Webb, S.6
Kerr, A.R.7
Deaton, A.8
Andrews, R.9
James, K.D.10
-
27
-
-
55449105221
-
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
-
Ku, M., Koche, R.P., Rheinbay, E., Mendenhall, E.M., Endoh, M., Mikkelsen, T.S., Presser, A., Nusbaum, C., Xie, X., Chi, A.S. et al. (2008) Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet., 4, e1000242.
-
(2008)
PLoS Genet.
, vol.4
-
-
Ku, M.1
Koche, R.P.2
Rheinbay, E.3
Mendenhall, E.M.4
Endoh, M.5
Mikkelsen, T.S.6
Presser, A.7
Nusbaum, C.8
Xie, X.9
Chi, A.S.10
-
28
-
-
84857190178
-
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
-
Lynch, M.D., Smith, A.J., De, G.M., Flenley, M., Hughes, J.R., Vernimmen, D., Ayyub, H., Sharpe, J.A., Sloane-Stanley, J.A., Sutherland, L. et al. (2012) An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J., 31, 317-329.
-
(2012)
EMBO J.
, vol.31
, pp. 317-329
-
-
Lynch, M.D.1
Smith, A.J.2
De, G.M.3
Flenley, M.4
Hughes, J.R.5
Vernimmen, D.6
Ayyub, H.7
Sharpe, J.A.8
Sloane-Stanley, J.A.9
Sutherland, L.10
-
29
-
-
78650684739
-
GC-rich sequence elements recruit PRC2 in mammalian ES cells
-
Mendenhall, E.M., Koche, R.P., Truong, T., Zhou, V.W., Issac, B., Chi, A.S., Ku, M. and Bernstein, B.E. (2010) GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet., 6, e1001244.
-
(2010)
PLoS Genet.
, vol.6
-
-
Mendenhall, E.M.1
Koche, R.P.2
Truong, T.3
Zhou, V.W.4
Issac, B.5
Chi, A.S.6
Ku, M.7
Bernstein, B.E.8
-
30
-
-
84863986133
-
Functions of DNA methylation: islands, start sites, gene bodies and beyond
-
Jones, P.A. (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet., 13, 484-492.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 484-492
-
-
Jones, P.A.1
-
31
-
-
84865755978
-
The accessible chromatin landscape of the human genome
-
Thurman, R.E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M.T., Haugen, E., Sheffield, N.C., Stergachis, A.B., Wang, H., Vernot, B. et al. (2012) The accessible chromatin landscape of the human genome. Nature, 489, 75-82.
-
(2012)
Nature
, vol.489
, pp. 75-82
-
-
Thurman, R.E.1
Rynes, E.2
Humbert, R.3
Vierstra, J.4
Maurano, M.T.5
Haugen, E.6
Sheffield, N.C.7
Stergachis, A.B.8
Wang, H.9
Vernot, B.10
-
32
-
-
0028104109
-
Sp1 elements protect a CpG island from de novo methylation
-
Brandeis, M., Frank, D., Keshet, I., Siegfried, Z., Mendelsohn, M., Nemes, A., Temper, V., Razin, A. and Cedar, H. (1994) Sp1 elements protect a CpG island from de novo methylation. Nature, 371, 435-438.
-
(1994)
Nature
, vol.371
, pp. 435-438
-
-
Brandeis, M.1
Frank, D.2
Keshet, I.3
Siegfried, Z.4
Mendelsohn, M.5
Nemes, A.6
Temper, V.7
Razin, A.8
Cedar, H.9
-
33
-
-
0027960055
-
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island
-
Macleod, D., Charlton, J., Mullins, J. and Bird, A.P. (1994) Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev., 8, 2282-2292.
-
(1994)
Genes Dev.
, vol.8
, pp. 2282-2292
-
-
Macleod, D.1
Charlton, J.2
Mullins, J.3
Bird, A.P.4
-
34
-
-
34047116826
-
Distribution, silencing potential and evolutionary impact of promoterDNAmethylation in the human genome
-
Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Paabo, S., Rebhan, M. and Schubeler, D. (2007) Distribution, silencing potential and evolutionary impact of promoterDNAmethylation in the human genome. Nat. Genet., 39, 457-466.
-
(2007)
Nat. Genet.
, vol.39
, pp. 457-466
-
-
Weber, M.1
Hellmann, I.2
Stadler, M.B.3
Ramos, L.4
Paabo, S.5
Rebhan, M.6
Schubeler, D.7
-
35
-
-
34547725157
-
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
-
Ooi, S.K., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument-Bromage, H., Tempst, P., Lin, S.P., Allis, C.D. et al. (2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature, 448, 714-717.
-
(2007)
Nature
, vol.448
, pp. 714-717
-
-
Ooi, S.K.1
Qiu, C.2
Bernstein, E.3
Li, K.4
Jia, D.5
Yang, Z.6
Erdjument-Bromage, H.7
Tempst, P.8
Lin, S.P.9
Allis, C.D.10
-
36
-
-
0030853287
-
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
-
Marin, M., Karis, A., Visser, P., Grosveld, F. and Philipsen, S. (1997) Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell, 89, 619-628.
-
(1997)
Cell
, vol.89
, pp. 619-628
-
-
Marin, M.1
Karis, A.2
Visser, P.3
Grosveld, F.4
Philipsen, S.5
|