Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

Journal of Biological Chemistry

Volumn 288, Issue 31, 2013, Pages 22809-22820

  Björkblom, Benny ^a,b   Adilbayeva, Altynai ^b   Maple Grødem, Jodi ^a,b   Piston, Dominik ^a,b   Ökvist, Mats ^c   Xu, Xiang Ming ^a,b   Brede, Cato ^a   Larsen, Jan Petter ^a   Møller, Simon Geir ^a,b,d  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF STAVANGER   (Norway)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING COPPER; GENETIC ALTERATIONS; METAL-BINDING PROTEIN; PARKINSON DISEASE;

CELL DEATH; DISEASES; PROTEINS;

METALS;

COPPER; DJ 1 PROTEIN; DOPAMINE; MERCURY;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR IMAGING; MOUSE; NONHUMAN; OXIDATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL DEATH; CYTOTOXICITY; DJ-1; METALS; OXIDATIVE STRESS; PARKINSON DISEASE;

ANIMALS; BASE SEQUENCE; CELL LINE; COPPER; DNA PRIMERS; DOPAMINE; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MERCURY; MICE; MODELS, MOLECULAR; ONCOGENE PROTEINS; OXIDATION-REDUCTION; PARKINSON DISEASE; PROTEIN BINDING;

EID: 84881221713     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.482091     Document Type: Article

References (37)

1. Hirsch, E., Graybiel, A. M., and Agid, Y. A. (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334, 345-348
2. Marsden, C. D. (1996) in Oxford Textbook of Medicine (Weatherall, D. J., Ledingham, J. G., and Warrell, D. A., eds) 3rd Ed., pp. 3998-4022, Oxford University Press, Oxford
3. Braak, H., Del Tredici, K., Rüb, U., de Vos, R. A., Jansen Steur, E. N., and Braak, E. (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211
4. Poewe, W. (2007) in Parkinson's Disease and Movement Disorders (Jankovic, J., and Tolosa, E., Eds) 5th Ed., Pp. 67-76, Lippincott Williams & Wilkins, Philadelphia
5. Wang, J. D., Huang, C. C., Hwang, Y. H., Chiang, J. R., Lin, J. M., and Chen, J. S. (1989) Manganese-induced parkinsonism: an outbreak due to an unrepaired ventilation control system in a ferromanganese smelter. Br. J. Ind. Med. 46, 856-859
6. Sikk, K., Haldre, S., Aquilonius, S. M., and Taba, P. (2011) Manganeseinduced Parkinsonism due to Ephedrone abuse. Parkinsons Dis. 2011, 865319
7. Gorell, J. M., Johnson, C. C., Rybicki, B. A., Peterson, E. L., Kortsha, G. X., Brown, G. G., and Richardson, R. J. (1999) Occupational exposure to manganese, copper, lead, iron, mercury, and zinc and the risk of Parkinson's disease. Neurotoxicology 20, 239-247
8. Semchuk, K. M., Love, E. J., and Lee, R. G. (1992) Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology 42, 1328-1335
9. Dexter, D. T., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F. R., Daniel, S. E., Lees, A. J., Jenner, P., and Marsden, C. D. (1991) Alterations in the levels of iron, ferritin, and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114, 1953-1975
10. Ngim, C. H., and Devathasan, G. (1989) Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson's disease. Neuroepidemiology 8, 128-141
11. Wirdefeldt, K., Adami, H. O., Cole, P., Trichopoulos, D., and Mandel, J. (2011) Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur. J. Epidemiol. 26, S1-S58
12. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259
13. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. relevance of iron in the pathogenesis of Parkinson's disease. J. Neurochem. 118, 939-957
14. Chandran, J. S., Lin, X., Zapata, A., Höke, A., Shimoji, M., Moore, S. O., Galloway, M. P., Laird, F. M., Wong, P. C., Price, D. L., Bailey, K. R., Crawley, J. N., Shippenberg, T., and Cai, H. (2008) Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol. Dis. 29, 505-514
15. Duhr, S., and Braun, D. (2006) Why molecules move along a temperature gradient. Proc. Natl. Acad. Sci. U.S.A. 103, 19678-19682
16. Schapira, A. H., and Jenner, P. (2011) Etiology and pathogenesis of Parkinson's disease. Mov. Disord. 26, 1049-1055
17. Ciarimboli, G. (2008) Organic cation transporters. Xenobiotica 38, 936-971
18. Hanson, G. T., Aggeler, R., Oglesbee, D., Cannon, M., Capaldi, R. A., Tsien, R. Y., and Remington, S. J. (2004) Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J. Biol. Chem. 279, 13044-13053
19. Tanner, C. M., Ottman, R., Goldman, S. M., Ellenberg, J., Chan, P., Mayeux, R., and Langston, J. W. (1999) Parkinson disease in twins: an etiologic study. JAMA 281, 341-346
20. Wirdefeldt, K., Gatz, M., Reynolds, C. A., Prescott, C. A., and Pedersen, N. L. (2011) Heritability of Parkinson disease in Swedish twins: a longitudinal study. Neurobiol. Aging 32, 1923
21. Marttila, R. J., Kaprio, J., Koskenvuo, M., and Rinne, U. K. (1988) Parkinson's disease in a nationwide twin cohort. Neurology 38, 1217-1219
22. Jomova, K., Vondrakova, D., Lawson, M., and Valko, M. (2010) Metals, oxidative stress and neurodegenerative disorders. Mol. Cell. Biochem. 345, 91-104
23. Liu, B., Gao, H. M., and Hong, J. S. (2003) Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ. Health Perspect. 111, 1065-1073
24. Díez, S. (2009) Human health effects of methylmercury exposure. Rev. Environ. Contam. Toxicol. 198, 111-132
25. Götz, M. E., Double, K., Gerlach, M., Youdim, M. B., and Riederer, P. (2004) The relevance of iron in the pathogenesis of Parkinson's disease. Ann. N.Y. Acad. Sci. 1012, 193-208
26. Blackinton, J., Ahmad, R., Miller, D. W., van der Brug, M. P., Canet-Avilés, R. M., Hague, S. M., Kaleem, M., and Cookson, M. R. (2005) Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization. Brain Res. Mol. Brain. Res. 134, 76-83
27. Görner, K., Holtorf, E., Odoy, S., Nuscher, B., Yamamoto, A., Regula, J. T., Beyer, K., Haass, C., and Kahle, P. J. (2004) Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. J. Biol. Chem. 279, 6943-6951
28. Malgieri, G., and Eliezer, D. (2008) Structural effects of Parkinson's disease linked DJ-1 mutations. Protein Sci. 17, 855-868
29. Ito, S., Kato, T., and Fujita, K. (1988) Covalent binding of catechols to proteins through the sulfhydryl-group. Biochem. Pharmacol. 37, 1707-1710
30. Akagawa, M., Ishii, Y., Ishii, T., Shibata, T., Yotsu-Yamashita, M., Suyama, K., and Uchida, K. (2006) Metal-catalyzed oxidation of protein-bound dopamine. Biochemistry 45, 15120-15128
31. Nyholm, D., Lennernäs, H., Gomes-Trolin, C., and Aquilonius, S. M. (2002) Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations. Clin. Neuropharmacol. 25, 89-96
32. Davis, S. J., and Vierstra, R. D. (1998) Soluble, highly fluorescent variants of green fluorescent protein (GFP) for use in higher plants. Plant Mol. Biol. 36, 521-528
33. Björkblom, B., Vainio, J. C., Hongisto, V., Herdegen, T., Courtney, M. J., and Coffey, E. T. (2008) All JNKs can kill, but nuclear localization is critical for neuronal death. J. Biol. Chem. 283, 19704-19713
34. Moore, D. J., Zhang, L., Dawson, T. M., and Dawson, V. L. (2003) A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. J. Neurochem. 87, 1558-1567
35. Studier, F. W. (2005) Protein production by auto-induction in high density shaking cultures. Protein Expr. Purif. 41, 207-234
36. Björkblom, B., Ostman, N., Hongisto, V., Komarovski, V., Filén, J. J., Nyman, T. A., Kallunki, T., Courtney, M. J., and Coffey, E. T. (2005) Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J. Neurosci. 25, 6350-6361
37. Leonard, G. A., Sole, V. A., Beteva, A., Gabadinho, J., Guijarro, M., Mc-Carthy, J., Marrocchelli, D., Nurizzo, D., McSweeney, S., and Mueller-Dieckmann, C.. (2009) Online collection and analysis of x-ray fluorescence spectra on the macromolecular crystallography beamlines of the ESRF. J. Appl. Crystallogr. 42, 333-335