Intra-cellular Staphylococcus aureus alone causes infection in vivo

European Cells and Materials

Volumn 25, Issue , 2012, Pages 341-350

  Hamza, Therwa ^a,b   Dietz, Matthew ^a   Pham, Danh ^a   Clovis, Nina ^a   Danley, Suzanne ^a   Li, Bingyun ^a,b,c  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c WVNano Initiative   (United States)

Author keywords

Chronic infection; In vivo; Infection recurrence; Intra cellular pathogen; Staphylococcus aureus

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIUM CULTURE; BLOOD CELL COUNT; BODY WEIGHT; BONE INFECTION; BONE RADIOGRAPHY; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE SEVERITY; HOST CELL; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; INTRACELLULAR MEMBRANE; MALE; NONHUMAN; OSTEOBLAST; PATHOGEN LOAD; PATHOGENESIS; RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

EID: 84881219463     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Almeida RA, Matthews KR, Cifrian E, Guidry AJ, Oliver SP (1996) Staphylococcus aureus invasion of bovine mammary epithelial cells. J Dairy Sci 79: 1021-1026.
2. Bayles KW, Wesson CA, Liou LE, Fox LK, Bohach GA, Trumble WR (1998) Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells. Infect Immun 66: 336-342.
3. Berendt T, Byren I (2004) Bone and joint infection. Clin Med 4: 510-518.
4. Boelens JJ, Dankert J, Murk JL, Weening JJ, van der Poll T, Dingemans KP, Koole L, Laman JD, Zaat SA (2000) Biomaterial-associated persistence of Staphylococcus epidermidis in pericatheter macrophages. J Infect Dis 181: 1337-1349.
5. Bosse MJ, Gruber HE, Ramp WK (2005) Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis: A case report. J Bone Joint Surg Am 87: 1343-1347.
6. Boyce BM, Lindsey BA, Clovis NB, Smith ES, Hobbs GR, Hubbard DF, Emery SE, Barnett JB, Li B (2012) Additive effects of exogenous IL-12 supplementation and antibiotic treatment in infection prophylaxis. J Orthop Res 30: 196-202.
7. Broekhuizen CA, de Boer L, Schipper K, Jones CD, Quadir S, Vandenbroucke-Grauls CM, Zaat SA (2008) Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri-implant tissue in mice despite rifampicin/vancomycin treatment. J Biomed Mater Res A 85: 498-505.
8. Canale ST (2003) Campbell's Operative Orthopaedics 10th ed. Mosby, St Louis, MO, pp 198-208.
9. Caver TE, O'Sullivan FX, Gold LI, Gresham HD (1996) Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice: IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection. J Clin Invest 98: 2496-2506.
10. Ciampolini J, Harding KG (2000) Pathophysiology of chronic bacterial osteomyelitis: Why do antibiotics fail so often? Postgrad Med J 76: 479-483.
11. Clarke SR, Foster SJ (2006) Surface adhesins of Staphylococcus aureus. Adv Microb Physiol 51: 187-224.
12. Clement S, Vaudaux P, Francois P, Schrenzel J, Huggler E, Kampf S, Chaponnier C, Lew D, Lacroix JS (2005) Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis. J Infect Dis 192: 1023-1028.
13. de Lissovoy G, Fraeman K, Hutchins V, Murphy D, Song D, Vaughn BB (2009) Surgical site infection: incidence and impact on hospital utilization and treatment costs. Am J Infect Control 37: 387-397.
14. Easmon CS, Lanyon H, Cole PJ (1978) Use of lysostaphin to remove cell-adherent staphylococci during in vitro assays of phagocyte function. Br J Exp Pathol 59: 381-385.
15. Ellington JK, Harris M, Webb L, Smith B, Smith T, Tan K, Hudson M (2003) Intracellular Staphylococcus aureus: A mechanism for the indolence of osteomyelitis. J Bone Joint Surg Br 85: 918-921.
16. Garzoni C, Kelley WL (2009) Staphylococcus aureus: new evidence for intracellular persistence. Trends Microbiol 17: 59-65.
17. Gresham HD, Lowrance JH, Caver TE, Wilson BS, Cheung AL, Lindberg FP (2000) Survival of Staphylococcus aureus inside neutrophils contributes to infection. J Immunol 164: 3713-3722.
18. Hamad MA, Skeldon AM, Valvano MA (2010) Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay. Appl Environ Microbiol 76: 3170-3176.
19. Hamrick TS, Diaz AH, Havell EA, Horton JR, Orndorff PE (2003) Influence of extracellular bactericidal agents on bacteria within macrophages. Infect Immun 71: 1016-1019.
20. Hamza T, Li B (2012) Staphylococcus aureus internalization and associated osteoblast responses. 2012 Meeting of the Orthopaedic Research Society, San Francisco, CA, USA, paper 919.
21. Hébert A, Sayasith K, Sénéchal S, Dubreuil P, Lagacé J (2000) Demonstration of intracellular Staphylococcus aureus in bovine mastitis alveolar cells and macrophages isolated from naturally infected cow milk. FEMS Microbiol Lett 193: 57-62.
22. Hudson MC, Ramp WK, Nicholson NC, Williams AS, Nousiainen MT (1995) Internalization of Staphylococcus aureus by cultured osteoblasts. Microb Pathog 19: 409-419.
23. Jevon M, Guo C, Ma B, Mordan N, Nair SP, Harris M, Henderson B, Bentley G, Meghji S (1999) Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts. Infect Immun 67: 2677-2681.
24. Johnson EN, Burns TC, Hayda RA, Hospenthal DR, Murray CK (2007) Infectious complications of open type III tibial fractures among combat casualties. Clin Infect Dis 45: 409-415.
25. Kapral FA, Shayegani MG (1959) Intracellular survival of staphylococci. J Exp Med 110: 123-138.
26. Kumar JK (2008) Lysostaphin: an antistaphylococcal agent. Appl Microbiol Biotechnol 80: 555-561.
27. Li B, Jiang B, Boyce BM, Lindsey BA (2009) Multilayer polypeptide nanoscale coatings incorporating IL-12 for the prevention of biomedical device-associated infections. Biomaterials 30: 2552-2558.
28. Li B, Jiang B, Dietz MJ, Smith ES, Clovis NB, Rao KMK (2010) Evaluation of local MCP-1 and IL-12 nanocoatings for infection prevention in open fractures. J Orthop Res 28: 48-54.
29. Lieberman JR, Callaway GH, Salvati EA, Pellicci PM, Brause BD (1994) Treatment of the infected total hip arthroplasty with a two-stage reimplantation protocol. Clin Orthop Relat Res 301: 205-212.
30. Lowrance JH, O'Sullivan FX, Caver TE, Waegell W, Gresham HD (1994) Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J Exp Med 180: 1693-1703.
31. Maurin M, Raoult D (2001) Use of aminoglycosides in treatment of infections due to intracellular bacteria. Antimicrob Agents Chemother 45: 2977-2986.
32. Melly MA, Thomison JB, Rogers DE (1960) Fate of staphylococci within human leukocytes. J Exp Med 112: 1121-1130.
33. Murray CK, Hsu JR, Solomkin JS, Keeling JJ, Andersen RC, Ficke JR, Calhoun JH (2008) Prevention and management of infections associated with combat-related extremity injuries. J Trauma 64 (Suppl): S239-S251.
34. Murray CK, Obremskey WT, Hsu JR, Andersen RC, Calhoun JH, Clasper JC, Whitman TJ, Curry TK, Fleming ME, Wenke JC, Ficke JR (2011) Prevention of infections associated with combat-related extremity injuries. J Trauma 71 (Suppl): S235-S257.
35. Patti JM, Höök M (1994) Microbial adhesins recognizing extracellular matrix macromolecules. Curr Opin Cell Biol 6: 752-758.
36. Plotkowski MC, de Bentzmann S, Pereira SH, Zahm JM, Bajolet-Laudinat O, Roger P, Puchelle E (1999) Pseudomonas aeruginosa internalization by human epithelial respiratory cells depends on cell differentiation, polarity, and junctional complex integrity. Am J Respir Cell Mol Biol 20: 880-890.
37. Proctor RA, van Langevelde P, Kristjansson M, Maslow JN, Arbeit RD (1995) Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin Infect Dis 20: 95-102.
38. Pull ter Gunne AF, Cohen DB (2009) Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery. Spine 34: 1422-1428.
39. Reilly SS, Hudson MC, Kellam JF, Ramp WK (2000) In vivo internalization of Staphylococcus aureus by embryonic chick osteoblasts. Bone 26: 63-70.
40. Rogers DE, Tompsett R (1952) The survival of staphylococci within human leukocytes. J Exp Med 95: 209-230.
41. Sax H, Lew D (1999) Osteomyelitis. Curr Infect Dis Rep 1: 261-266.
42. Sugarman B, Young EJ (1989) Infections associated with prosthetic devices: magnitude of the problem. Infect Dis Clin North Am 3: 1871-1898.
43. Takahira N, Itoman M, Higashi K, Uchiyama K, Miyabe M, Naruse K (2003) Treatment outcome of two-stage revision total hip arthroplasty for infected hip arthroplasty using antibiotic-impregnated cement spacer. J Orthop Sci 8: 26-31.
44. Verdrengh M, Tarkowski A (1997) Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infect Immun 65: 2517-2521.
45. Vriesema AJ, Beekhuizen H, Hamdi M, Soufan A, Lammers A, Willekens B, Bakker O, Welten AG, Veltrop MH, van De Gevel JS, Dankert J, Zaat SA (2000) Altered gene expression in Staphylococcus aureus upon interaction with human endothelial cells. Infect Immun 68: 1765-1772.
46. Wright KM, Friedland JS (2002) Differential regulation of chemokine secretion in tuberculous and staphylococcal osteomyelitis. J Bone Miner Res 17: 1680-1690.
47. Zalavras CG, Patzakis MJ (2003) Open fractures: evaluation and management. J Amer Acad Orthop Surg 11: 212-219.