Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 9, 2013, Pages 2026-2037

  Petrova, Mariya I ^a,b   Mathys, Leen ^c   Lebeer, Sarah ^a,b   Noppen, Sam ^c   Van Damme, Els J M ^d   Tanaka, Haruo ^e   Igarashi, Yasuhiro ^f   Vaneechoutte, Mario ^d   Vanderleyden, Jos ^a   Balzarini, Jan ^c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e IWAKI MEISEI UNIVERSITY   (Japan)

^f TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Adhesion; Antimicrobial agents; Antiretroviral therapy; Bacterial biofilms; HIV Aids; Lactic acid bacteria; Microbicides

Indexed keywords

CD209 ANTIGEN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM ISOLATION; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION CONTROL; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LACTOBACILLUS GASSERI; LACTOBACILLUS HELVETICUS; LACTOBACILLUS JENSENII; LACTOBACILLUS PLANTARUM; LACTOBACILLUS REUTERI; LACTOBACILLUS SALIVARIUS; MICROFLORA; NONHUMAN; VAGINA; VIRUS PARTICLE; VIRUS TRANSMISSION;

ADHESION; ANTIMICROBIAL AGENTS; ANTIRETROVIRAL THERAPY; BACTERIAL BIOFILMS; HIV/AIDS; LACTIC ACID BACTERIA; MICROBICIDES;

ANTI-HIV AGENTS; CELL LINE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LACTOBACILLUS; LECTINS; VAGINA;

EID: 84881218720     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt152     Document Type: Article

References (51)

1. Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol 2007; 5: 583-97.
2. François KO, Balzarini J. Potential of carbohydrate-binding agents as therapeutics against enveloped viruses. Med Res Rev 2012; 32: 349-87.
3. Lebeer S, Vanderleyden J, De Keersmaecker SC. Genes and molecules of lactobacilli supporting probiotic action. Microbiol Mol Biol Rev 2008; 72: 728-64.
4. Francius G, Lebeer S, Alsteens D et al. Detection, localization, and conformational analysis of single polysaccharide molecules on live bacteria. ACS Nano 2008; 2: 1921-9.
5. Lebeer S, Verhoeven TL, Francius G et al. Identification of a gene cluster for the biosynthesis of a long, galactose-rich exopolysaccharide in Lactobacillus rhamnosus GG and functional analysis of the priming glycosyltransferase. Appl Environ Microbiol 2009; 75: 3554-63.
6. Lebeer S, Claes IJ, Verhoeven TL et al. Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine. Microb Biotechnol 2011; 4: 368-74.
7. Reid G. Probiotic lactobacilli for urogenital health in women. J Clin Gastroenterol 2008; 42 Suppl 3: S234-6.
8. Ravel J, Gajer P, Abdo Z et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2011; 108 Suppl 1: 4680-7.
9. Geijtenbeek TB, Kwon DS, Torensma R et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100: 587-97.
10. Princen K, Hatse S, Vermeire K et al. Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists. Retrovirology 2004; 1: 2.
11. Kaku H, Van Damme EJ, Peumans WJ et al. Carbohydrate-binding specificity of the daffodil (Narcissus pseudonarcissus) and amaryllis (Hippeastrum hybr.) bulb lectins. Arch Biochem Biophys 1990; 279: 298-304.
12. Shibuya N, Goldstein IJ, Van Damme EJ et al. Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb. J Biol Chem 1988; 263: 728-34.
13. Tanaka H, Chiba H, Inokoshi J et al. Mechanism by which the lectin actinohivin blocks HIV infection of target cells. Proc Natl Acad Sci USA 2009; 106: 15633-8.
14. Lee RT, Gabius HJ, Lee YC. Thermodynamic parameters of the interaction of Urtica dioica agglutinin with N-acetylglucosamine and its oligomers. Glycoconj J 1998; 15: 649-55.
15. Scanlan CN, Pantophlet R, Wormald MR et al. The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of a12 mannose residues on the outer face of gp120. J Virol 2002; 76: 7306-21.
16. Fujikawa K, Tsukamoto Y, Oki T et al. Spectroscopic studies on the interaction of pradimicin BMY-28864 with mannose derivatives. Glycobiology 1998; 8: 407-14.
17. Van Damme EJM, Broekaert WF, Peumans WJ. The Urtica dioica agglutinin is a complex mixture of isolectins. Plant Physiol 1988; 86: 598-601.
18. Van Damme EJM, Allen AK, Peumans WJ. Related mannose-specific lectins from different species of the family Amaryllidaceae. Plant Physiol 1988; 73: 52-7.
19. Chiba H, Inokoshi J, Okamoto M et al. Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities. Biochem Biophys Res Commun 2001; 282: 595-601.
20. Oki T, Konishi M, Tomatsu K et al. Pradimicin, a novel class of potent antifungal antibiotics. J Antibiot (Tokyo) 1988; 41: 1701-4.
21. Saitoh K, Tenmyo O, Yamamoto S et al. Pradimicin S, a new pradimicin analog. I. Taxonomy, fermentation and biological activities. J Antibiot (Tokyo) 1993; 46: 580-8.
22. Saitoh K, Furumai T, Oki T et al. Pradimicin S, a new pradimicin analog. III. Application of the frit-FAB LC/MS technique to the elucidation of the pradimicin S biosynthetic pathway. J Antibiot (Tokyo) 1995; 48: 162-8.
23. Covens K, Dekeersmaeker N, Schrooten Y et al. Novel recombinant virus assay for measuring susceptibility ofhumanimmunodeficiency virus type 1 group M subtypes to clinically approved drugs. J Clin Microbiol 2009; 47: 2232-42.
24. Weber J, Weberova J, Carobene M et al. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. J Virol Methods 2006; 136: 102-17.
25. Kankainen M, Paulin L, Tynkkynen S et al. Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human-mucus binding protein. Proc Natl Acad Sci USA 2009; 106: 17193-8.
26. Chan RC, Reid G, Irvin RT et al. Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Infect Immun 1985; 47: 84-9.
27. Reid G. The scientific basis for probiotic strains of Lactobacillus. Appl Environ Microbiol 1999; 65: 3763-6.
28. Reid G, Bruce AW, Fraser N et al. Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol 2001; 30: 49-52.
29. Moore WE, Hash DE, Holdeman LV et al. Polyacrylamide slab gel electrophoresis of soluble proteins for studies of bacterial floras. Appl Environ Microbiol 1980; 39: 900-7.
30. Gasser F, Mandel M, Rogosa M. Lactobacillus jensenii sp.nov., a new representative of the subgenus Thermobacterium. J Gen Microbiol 1970; 62: 219-22.
31. Rogosa M, Wiseman RF, Mitchell JA et al. Species differentiation of oral lactobacilli from man including descriptions of Lactobacillus salivarius nov spec and Lactobacillus cellobiosus nov spec. J Bacteriol 1953; 65: 681-99.
32. Kleerebezem M, Boekhorst J, van Kranenburg R et al. Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci USA 2003; 100: 1990-5.
33. Blattner FR, Plunkett G III, Bloch CA et al. The complete genome sequence of Escherichia coli K-12. Science 1997; 277: 1453-62.
34. Vidwans SJ, Ireton K, Grossman AD. Possible role for the essential GTP-binding protein Obg in regulating the initiation of sporulation in Bacillus subtilis. J Bacteriol 1995; 177: 3308-11.
35. Hansen PA. Type strains of Lactobacillus species. A report by the taxonomic subcommittee on lactobacilli and closely related organisms. American Type Culture Collection, Rockville, MD, 1968.
36. Balzarini J, Van Laethem K, Hatse S et al. Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins. J Virol 2004; 78: 10617-27.
37. Balzarini J, Frančois KO, Van Laethem K et al. Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use. Antimicrob Agents Chemother 2010; 54: 1425-35.
38. Feinberg H, Mitchell DA, Drickamer K et al. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science 2001; 294: 2163-6.
39. Sawada Y, Numata K, Murakami T et al. Calcium-dependent anticandidal action of pradimicin A. J Antibiot (Tokyo) 1990; 43: 715-21.
40. Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol 2003; 1: 25-34.
41. Balzarini J, Hatse S, Vermeire K et al. Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection. Antimicrob Agents Chemother 2004; 48: 3858-70.
42. Balzarini J, Van Laethem K, Hatse S et al. Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the Achilles heel of HIV. J Biol Chem 2005; 280: 41005-14.
43. Hoorelbeke B, Huskens D, Férir Get al. Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope. Antimicrob Agents Chemother 2010; 54: 3287-301.
44. Bolton M, van der Straten A, Cohen CR. Probiotics: potential to prevent HIV and sexually transmitted infections in women. Sex Transm Dis 2008; 35: 214-25.
45. Cribby S, Taylor M, Reid G. Vaginal microbiota and the use of probiotics. Interdiscip Perspect Infect Dis 2008; 29: 256490.
46. KlebanoffSJ, CoombsRW. Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission. J Exp Med 1991; 174: 289-92.
47. Martin HL, Richardson BA, Nyange PM et al. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180: 1863-8.
48. Giomarelli B, Provvedi R, Meacci F et al. The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1. AIDS 2002; 16: 1351-6.
49. Inokoshi J, Chiba H, Asanuma S et al. Molecular cloning of actinohivin, a novel anti-HIV protein from an actinomycete, and its expression in Escherichia coli. Biochem Biophys Res Commun 2001; 281: 1261-5.
50. Huskens D, Van Laethem K, Vermeire K et al. Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12. Virology 2007; 360: 294-304.
51. Balzarini J, Van Laethem K, Daelemans D et al. Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus. J Virol 2007; 81: 362-73.