A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis

Antiviral Research

Volumn 100, Issue 1, 2013, Pages 29-37

  Martinez Gil, Luis ^a   Alamares Sapuay, Judith G ^a   Ramana Reddy, M V ^a   Goff, Peter H ^a   Premkumar Reddy, E ^a   Palese, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Influenza virus; Kinase inhibitor; Viral RNA synthesis

Indexed keywords

ANTIVIRUS AGENT; CYCLIN A; CYCLIN B; CYCLIN D1; CYCLIN D3; CYCLIN T1; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; ON 108050; ON 108080; ON 108110; ON 123300; ON 123790; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS RNA; NA PROTEIN, INFLUENZA A VIRUS; PHOSPHOTRANSFERASE INHIBITOR; SIALIDASE; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; MOUSE; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLUENZA; INFLUENZA VIRUS; METABOLISM; PHYSIOLOGY; VIRAL RNA SYNTHESIS; VIROLOGY;

INFLUENZA A VIRUS; NEWCASTLE DISEASE VIRUS; ORTHOMYXOVIRIDAE; VESICULAR STOMATITIS VIRUS;

INFLUENZA VIRUS; KINASE INHIBITOR; VIRAL RNA SYNTHESIS;

ANTIVIRAL AGENTS; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; NEURAMINIDASE; PROTEIN KINASE INHIBITORS; RNA, VIRAL; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84881188978     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.07.010     Document Type: Article

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