Genetic influences on the outcome of anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration

Ophthalmology

Volumn 120, Issue 8, 2013, Pages 1641-1648

  Abedi, Farshad ^a   Wickremasinghe, Sanjeewa ^a   Richardson, Andrea J ^a   Islam, Amirul F M ^a   Guymer, Robyn H ^a   Baird, Paul N ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BEVACIZUMAB; CFHR1 5 PROTEIN; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; COMPLEMENT FACTOR H RELATED; HIGH TEMPERATURE REQUIREMENT FACTOR A1; PROTEIN; RANIBIZUMAB; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; FEMALE; FOLLOW UP; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA MACULA AGE RELATED DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME; VISUAL ACUITY;

AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; COHORT STUDIES; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; COMPLEMENT SYSTEM PROTEINS; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; PROTEINS; RETREATMENT; SERINE ENDOPEPTIDASES; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY; WET MACULAR DEGENERATION;

EID: 84881183687     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2013.01.014     Document Type: Article

References (38)

1. P.J. Rosenfeld, D.M. Brown, J.S. Heier MARINA Study Group Ranibizumab for neovascular age-related macular degeneration N Engl J Med 355 2006 1419 1431
2. D.M. Brown, M. Michels, P.K. Kaiser ANCHOR Study Group Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR Study Ophthalmology 116 2009 57 65
3. CATT Research Group Ranibizumab and bevacizumab for neovascular age-related macular degeneration N Engl J Med 364 2011 1897 1908
4. IVAN Study Investigators U. Chakravarthy, S.P. Harding, and C.A. Rogers Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial Ophthalmology 119 2012 1399 1411
5. S.J. Clark, P.N. Bishop, and A.J. Day Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology Biochem Soc Trans 38 2010 1342 1348
6. J.L. Haines, M.A. Hauser, and S. Schmidt Complement factor H variant increases the risk of age-related macular degeneration Science 308 2005 419 421
7. D.D. Despriet, C.C. Klaver, and J.C. Witteman Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration JAMA 296 2006 301 309
8. M. Li, P. Atmaca-Sonmez, and M. Othman CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration Nat Genet 38 2006 1049 1054
9. J. Jakobsdottir, Y.P. Conley, and D.E. Weeks Susceptibility genes for age-related maculopathy on chromosome 10q26 Am J Hum Genet 77 2005 389 407
10. S.A. Fisher, G.R. Abecasis, and B.M. Yashar Meta-analysis of genome scans of age-related macular degeneration Hum Mol Genet 14 2005 2257 2264
11. J. Maller, S. George, and S. Purcell Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration Nat Genet 38 2006 1055 1059
12. D. Gibbs, Z. Yang, and R. Constantine Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration Vision Res 48 2008 685 689
13. N.P. Tang, B. Zhou, B. Wang, and R.B. Yu HTRA1 promoter polymorphism and risk of age-related macular degeneration: a meta-analysis Ann Epidemiol 19 2009 740 745
14. Y. Soysal, U.U. Inan, T. Kusbeci, and N. Imirzalioglu Age-related macular degeneration and association of CFH Y402H and LOC387715 A69S polymorphisms in a Turkish population DNA Cell Biol 31 2012 323 330
15. T. Lepre, R. Cascella, and F. Missiroli Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration [letter] Am J Ophthalmol 152 2011 325 326
16. Y. Tong, J. Liao, and Y. Zhang LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: a HuGE review and meta-analysis Mol Vis [serial online] 16 2010 1958 1981 Available at: http://www.molvis.org/molvis/v16/a213/ Accessed December 24, 2012
17. I. Kaur, S. Katta, and A. Hussain Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients Invest Ophthalmol Vis Sci 49 2008 1771 1776
18. Z. Yang, N.J. Camp, and H. Sun A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration Science 314 2006 992 993
19. N. Leveziel, N. Puche, and J. Zerbib Genetic factors associated with age-related macular degeneration [in French] Med Sci (Paris) 26 2010 509 515
20. T. Tsuchihashi, K. Mori, and K. Horie-Inoue Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration Ophthalmology 118 2011 93 100
21. S.P. Seitsonen, I.E. Jarvela, and S. Meri The effect of complement factor H Y402H polymorphism on the outcome of photodynamic therapy in age-related macular degeneration Eur J Ophthalmol 17 2007 943 949
22. X. Feng, J. Xiao, and B. Longville Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration Ophthalmology 116 2009 1908 1912
23. M. McKibbin, M. Ali, and S. Bansal CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration Br J Ophthalmol 96 2012 208 212
24. S.J. Teper, A. Nowinska, and J. Pilat Involvement of genetic factors in the response to a variable-dosing ranibizumab treatment regimen for age-related macular degeneration Mol Vis [serial online] 16 2010 2598 2604 Available at: http://www.molvis.org/molvis/v16/a278/ Accessed December 24, 2012
25. C. Nischler, H. Oberkofler, and C. Ortner Complement factor H Y402H gene polymorphism and response to intravitreal bevacizumab in exudative age-related macular degeneration [report online] Acta Ophthalmol 89 2011 e344 e349
26. B. Kloeckener-Gruissem, D. Barthelmes, and S. Labs Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD Invest Ophthalmol Vis Sci 52 2011 4694 4702
27. S.S. Wickremasinghe, J. Xie, and J. Lim Variants in the APOE gene are associated with improved outcome after anti-VEGF treatment for neovascular AMD Invest Ophthalmol Vis Sci 52 2011 4072 4079
28. R.K. Shuler Jr., S. Schmidt, and P. Gallins Phenotype analysis of patients with the risk variant LOC387715 (A69S) in age-related macular degeneration Am J Ophthalmol 145 2008 303 307
29. N. Fuse, M. Mengkegale, and A. Miyazawa Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration Am J Ophthalmol 151 2011 550 556
30. H. Jiang, Y. Qu, and G. Dang Analyses of single nucleotide polymorphisms and haplotype linkage of LOC387715 and the HTRA1 gene in exudative age-related macular degeneration in a Chinese cohort Retina 29 2009 974 979
31. M.T. Andreoli, M.A. Morrison, and B.J. Kim Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration Am J Ophthalmol 148 2009 869 874
32. A. Dewan, M. Liu, and S. Hartman HTRA1 promoter polymorphism in wet age-related macular degeneration Science 314 2006 989 992
33. L. Sobrin, R. Reynolds, and Y. Yu ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration Am J Ophthalmol 151 2011 345 352
34. J. Tocharus, A. Tsuchiya, and M. Kajikawa Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling Dev Growth Differ 46 2004 257 274
35. X. Ding, M. Patel, and C.C. Chan Molecular pathology of age-related macular degeneration Prog Retin Eye Res 28 2009 1 18
36. L. Zhang, S.L. Lim, and H. Du High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-beta family member growth differentiation factor 6 J Biol Chem 287 2012 1520 1526
37. J. Feher, I. Kovacs, and M. Artico Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration Neurobiol Aging 27 2006 983 993
38. A.J. Richardson, F.M. Islam, and K.Z. Aung An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration Invest Ophthalmol Vis Sci 51 2010 4932 4936