-
1
-
-
0026395163
-
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA
-
Houck KA, Ferrara N, Winer J, Cachianes G, Li B, et al. (1991) The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814.
-
(1991)
Mol Endocrinol
, vol.5
, pp. 1806-1814
-
-
Houck, K.A.1
Ferrara, N.2
Winer, J.3
Cachianes, G.4
Li, B.5
-
2
-
-
54549123309
-
VEGF-A splicing: the key to anti-angiogenic therapeutics?
-
Harper SJ, Bates DO, (2008) VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 8: 880-887.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 880-887
-
-
Harper, S.J.1
Bates, D.O.2
-
3
-
-
0037098860
-
VEGF-A165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
-
Bates DO, Cui TG, Doughty JM, Winkler M, Sugiono M, et al. (2002) VEGF-A165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res 62: 4123-4131.
-
(2002)
Cancer Res
, vol.62
, pp. 4123-4131
-
-
Bates, D.O.1
Cui, T.G.2
Doughty, J.M.3
Winkler, M.4
Sugiono, M.5
-
4
-
-
70349663980
-
VEGF121b, a new member of the VEGFxxxb family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo
-
Rennel E, Varey AHR, Churchill AJ, Wheatley ER, Stewart L, et al. (2009) VEGF121b, a new member of the VEGFxxxb family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br J Cancer 101: 1250-1257.
-
(2009)
Br J Cancer
, vol.101
, pp. 1250-1257
-
-
Rennel, E.1
Varey, A.H.R.2
Churchill, A.J.3
Wheatley, E.R.4
Stewart, L.5
-
5
-
-
40749102955
-
5-Aza-2′-deoxycytidine increases the expression of anti-angiogenic vascular endothelial growth factor 189b variant in human lung microvascular endothelial cells
-
Miller-Kasprzak E, Jagodzinski PP, (2008) 5-Aza-2′-deoxycytidine increases the expression of anti-angiogenic vascular endothelial growth factor 189b variant in human lung microvascular endothelial cells. Biomed Pharmacother 62: 158-163.
-
(2008)
Biomed Pharmacother
, vol.62
, pp. 158-163
-
-
Miller-Kasprzak, E.1
Jagodzinski, P.P.2
-
6
-
-
27744489034
-
Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor
-
Perrin RM, Konopatskaya O, Qiu Y, Harper S, Bates DO, et al. (2005) Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor. Diabetologia 48: 2422-2427.
-
(2005)
Diabetologia
, vol.48
, pp. 2422-2427
-
-
Perrin, R.M.1
Konopatskaya, O.2
Qiu, Y.3
Harper, S.4
Bates, D.O.5
-
7
-
-
7444240909
-
VEGF-A165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression
-
Woolard J, Wang WY, Bevan HS, Qiu Y, Morbidelli L, et al. (2004) VEGF-A165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res 64: 7822-7835.
-
(2004)
Cancer Res
, vol.64
, pp. 7822-7835
-
-
Woolard, J.1
Wang, W.Y.2
Bevan, H.S.3
Qiu, Y.4
Morbidelli, L.5
-
8
-
-
33947217234
-
Impaired glomerular maturation and lack of VEGF-A165b in Denys-Drash syndrome
-
Schumacher VA, Jeruschke S, Eitner F, Becker JU, Pitschke G, et al. (2007) Impaired glomerular maturation and lack of VEGF-A165b in Denys-Drash syndrome. J Am Soc Nephrol 18: 719-729.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 719-729
-
-
Schumacher, V.A.1
Jeruschke, S.2
Eitner, F.3
Becker, J.U.4
Pitschke, G.5
-
9
-
-
84881128683
-
Enhanced levels of VEGF and reduced levels of VEGFxxxb in the vitreous of patients with retinal vein occlusion
-
Michels D, Rennel ES, Feltgen N, Martin G, Stahl A, et al. (2008) Enhanced levels of VEGF and reduced levels of VEGFxxxb in the vitreous of patients with retinal vein occlusion. Acta Ophthalmol Scand 86: 59.
-
(2008)
Acta Ophthalmol Scand
, vol.86
, pp. 59
-
-
Michels, D.1
Rennel, E.S.2
Feltgen, N.3
Martin, G.4
Stahl, A.5
-
10
-
-
79961031252
-
Overexpression of VEGF-A165b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis
-
Manetti M, Guiducci S, Romano E, Ceccarelli C, Bellando-Randone S, et al. (2011) Overexpression of VEGF-A165b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis. Circ Res 109: e14-26.
-
(2011)
Circ Res
, vol.109
-
-
Manetti, M.1
Guiducci, S.2
Romano, E.3
Ceccarelli, C.4
Bellando-Randone, S.5
-
11
-
-
84861761532
-
Genetic variation in vascular endothelial growth factor-a and lung function
-
Simpson A, Custovic A, Tepper R, Graves P, Stern DA, et al. (2012) Genetic variation in vascular endothelial growth factor-a and lung function. Am J Respir Crit Care Med 185: 1197-1204.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 1197-1204
-
-
Simpson, A.1
Custovic, A.2
Tepper, R.3
Graves, P.4
Stern, D.A.5
-
12
-
-
77949318969
-
Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis
-
Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, et al. (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem 285: 5532-5540.
-
(2010)
J Biol Chem
, vol.285
, pp. 5532-5540
-
-
Nowak, D.G.1
Amin, E.M.2
Rennel, E.S.3
Hoareau-Aveilla, C.4
Gammons, M.5
-
13
-
-
83455263848
-
WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
-
Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, et al. (2011) WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing. Cancer Cell 20: 768-780.
-
(2011)
Cancer Cell
, vol.20
, pp. 768-780
-
-
Amin, E.M.1
Oltean, S.2
Hua, J.3
Gammons, M.V.4
Hamdollah-Zadeh, M.5
-
14
-
-
56349136033
-
Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors
-
Nowak DG, Woolard J, Amin EM, Konopatskaya O, Saleem MA, et al. (2008) Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors. J Cell Sci 121: 3487-3495.
-
(2008)
J Cell Sci
, vol.121
, pp. 3487-3495
-
-
Nowak, D.G.1
Woolard, J.2
Amin, E.M.3
Konopatskaya, O.4
Saleem, M.A.5
-
15
-
-
42149152015
-
VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
-
Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, et al. (2008) VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy. Br J Cancer 98: 1366-1379.
-
(2008)
Br J Cancer
, vol.98
, pp. 1366-1379
-
-
Varey, A.H.1
Rennel, E.S.2
Qiu, Y.3
Bevan, H.S.4
Perrin, R.M.5
-
16
-
-
84881162705
-
VEGF(165) b in the developing vasculatures of the fetal human eye
-
Baba T, McLeod DS, Edwards MM, Merges C, Sen T, et al. (2011) VEGF(165) b in the developing vasculatures of the fetal human eye. Dev Dyn.
-
(2011)
Dev Dyn
-
-
Baba, T.1
McLeod, D.S.2
Edwards, M.M.3
Merges, C.4
Sen, T.5
-
17
-
-
33645833000
-
Unbalanced alternative splicing and its significance in cancer
-
Venables JP, (2006) Unbalanced alternative splicing and its significance in cancer. Bioessays 28: 378-386.
-
(2006)
Bioessays
, vol.28
, pp. 378-386
-
-
Venables, J.P.1
-
18
-
-
2442694425
-
Transcriptome and genome conservation of alternative splicing events in humans and mice
-
Sugnet CW, Kent WJ, Ares M, Jr. Haussler D (2004) Transcriptome and genome conservation of alternative splicing events in humans and mice. Pac Symp Biocomput: 66-77.
-
(2004)
Pac Symp Biocomput
, pp. 66-77
-
-
Sugnet, C.W.1
Kent, W.J.2
Ares Jr., M.3
Haussler, D.4
-
19
-
-
33748596625
-
Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons
-
Zhang XH, Chasin LA, (2006) Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons. Proc Natl Acad Sci U S A 103: 13427-13432.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13427-13432
-
-
Zhang, X.H.1
Chasin, L.A.2
-
20
-
-
0037705467
-
Conservation of human alternative splice events in mouse
-
Thanaraj TA, Clark F, Muilu J, (2003) Conservation of human alternative splice events in mouse. Nucleic Acids Res 31: 2544-2552.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 2544-2552
-
-
Thanaraj, T.A.1
Clark, F.2
Muilu, J.3
-
21
-
-
1542563409
-
Initial sequencing and comparative analysis of the mouse genome
-
Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, et al. (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420: 520-562.
-
(2002)
Nature
, vol.420
, pp. 520-562
-
-
Waterston, R.H.1
Lindblad-Toh, K.2
Birney, E.3
Rogers, J.4
Abril, J.F.5
-
22
-
-
80052899736
-
The evolution of alternative splicing exons in vascular endothelial growth factor A. Gene
-
Xu J, Dou T, Liu C, Fu M, Huang Y, et al. (2011) The evolution of alternative splicing exons in vascular endothelial growth factor A. Gene. 487: 143-150.
-
(2011)
, vol.487
, pp. 143-150
-
-
Xu, J.1
Dou, T.2
Liu, C.3
Fu, M.4
Huang, Y.5
-
23
-
-
84860442891
-
Do anti-angiogenic VEGF (VEGFxxxb) isoforms exist? A cautionary tale
-
Harris S, Craze M, Newton J, Fisher M, Shima DT, et al. (2012) Do anti-angiogenic VEGF (VEGFxxxb) isoforms exist? A cautionary tale. PLoS One 7: e35231.
-
(2012)
PLoS One
, vol.7
-
-
Harris, S.1
Craze, M.2
Newton, J.3
Fisher, M.4
Shima, D.T.5
-
24
-
-
79955589140
-
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms
-
Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, et al. (2011) Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci 2011: 273-278.
-
(2011)
Chem Sci
, vol.2011
, pp. 273-278
-
-
Woolard, J.1
Vousden, W.2
Moss, S.J.3
Krishnakumar, A.4
Gammons, M.V.5
-
25
-
-
41649101428
-
The endogenous anti-angiogenic VEGF isoform, VEGF-A165b inhibits human tumour growth in mice
-
Rennel E, Waine E, Guan H, Schuler Y, Leenders W, et al. (2008) The endogenous anti-angiogenic VEGF isoform, VEGF-A165b inhibits human tumour growth in mice. Br J Cancer 98: 1250-1257.
-
(2008)
Br J Cancer
, vol.98
, pp. 1250-1257
-
-
Rennel, E.1
Waine, E.2
Guan, H.3
Schuler, Y.4
Leenders, W.5
-
26
-
-
34447316207
-
Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma
-
Pritchard-Jones RO, Dunn DB, Qiu Y, Varey AH, Orlando A, et al. (2007) Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Br J Cancer 97: 223-230.
-
(2007)
Br J Cancer
, vol.97
, pp. 223-230
-
-
Pritchard-Jones, R.O.1
Dunn, D.B.2
Qiu, Y.3
Varey, A.H.4
Orlando, A.5
-
27
-
-
0023884059
-
Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue
-
Jordana M, Schulman J, McSharry C, Irving LB, Newhouse MT, et al. (1988) Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis 137: 579-584.
-
(1988)
Am Rev Respir Dis
, vol.137
, pp. 579-584
-
-
Jordana, M.1
Schulman, J.2
McSharry, C.3
Irving, L.B.4
Newhouse, M.T.5
-
28
-
-
0025370967
-
Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence
-
Williams AC, Harper SJ, Paraskeva C, (1990) Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence. Cancer Res 50: 4724-4730.
-
(1990)
Cancer Res
, vol.50
, pp. 4724-4730
-
-
Williams, A.C.1
Harper, S.J.2
Paraskeva, C.3
-
29
-
-
80955180589
-
Levels of VEGF but not VEGF(165b) are increased in the vitreous of patients with retinal vein occlusion
-
e291
-
Ehlken C, Rennel ES, Michels D, Grundel B, Pielen A, et al. (2010) Levels of VEGF but not VEGF(165b) are increased in the vitreous of patients with retinal vein occlusion. Am J Ophthalmol 152: 298-303 e291.
-
(2010)
Am J Ophthalmol
, vol.152
, pp. 298-303
-
-
Ehlken, C.1
Rennel, E.S.2
Michels, D.3
Grundel, B.4
Pielen, A.5
-
30
-
-
77952752660
-
VEGF in the lung: a role for novel isoforms
-
Varet J, Douglas SK, Gilmartin L, Medford AR, Bates DO, et al. (2010) VEGF in the lung: a role for novel isoforms. Am J Physiol Lung Cell Mol Physiol 298: L768-774.
-
(2010)
Am J Physiol Lung Cell Mol Physiol
, vol.298
-
-
Varet, J.1
Douglas, S.K.2
Gilmartin, L.3
Medford, A.R.4
Bates, D.O.5
-
31
-
-
1642280409
-
Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF-A165b) mRNA and protein
-
Cui TG, Foster RR, Saleem M, Mathieson PW, Gillatt DA, et al. (2004) Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF-A165b) mRNA and protein. Am J Physiol Renal Physiol 286: F767-773.
-
(2004)
Am J Physiol Renal Physiol
, vol.286
-
-
Cui, T.G.1
Foster, R.R.2
Saleem, M.3
Mathieson, P.W.4
Gillatt, D.A.5
-
32
-
-
50549086120
-
Levels of vascular endothelial growth factor-A165b (VEGF-A165b are elevated in experimental glaucoma
-
Ergorul C, Ray A, Huang W, Darland D, Luo ZK, et al. (2008) Levels of vascular endothelial growth factor-A165b (VEGF-A165b are elevated in experimental glaucoma. Mol Vis 14: 1517-1524.
-
(2008)
Mol Vis
, vol.14
, pp. 1517-1524
-
-
Ergorul, C.1
Ray, A.2
Huang, W.3
Darland, D.4
Luo, Z.K.5
-
33
-
-
77957954487
-
Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth
-
Peiris-Pages M, Harper SJ, Bates DO, Ramani P, (2010) Balance of pro- versus anti-angiogenic splice isoforms of vascular endothelial growth factor as a regulator of neuroblastoma growth. J Pathol 222: 138-147.
-
(2010)
J Pathol
, vol.222
, pp. 138-147
-
-
Peiris-Pages, M.1
Harper, S.J.2
Bates, D.O.3
Ramani, P.4
-
34
-
-
84866354517
-
The balance of proangiogenic and antiangiogenic VEGFA isoforms regulate follicle development
-
McFee RM, Rozell TG, Cupp AS, (2012) The balance of proangiogenic and antiangiogenic VEGFA isoforms regulate follicle development. Cell Tissue Res 349: 635-647.
-
(2012)
Cell Tissue Res
, vol.349
, pp. 635-647
-
-
McFee, R.M.1
Rozell, T.G.2
Cupp, A.S.3
-
35
-
-
84869217914
-
Association Between VEGF Splice Isoforms And Progression Free Survival In Metastatic Colorectal Cancer Patients Treated With Bevacizumab
-
Bates DO, Catalano PJ, Symonds KE, Varey AHR, Ramani P, et al. (2012) Association Between VEGF Splice Isoforms And Progression Free Survival In Metastatic Colorectal Cancer Patients Treated With Bevacizumab. Clin Cancer Res in press.
-
(2012)
Clin Cancer Res in press
-
-
Bates, D.O.1
Catalano, P.J.2
Symonds, K.E.3
Varey, A.H.R.4
Ramani, P.5
-
36
-
-
79960690759
-
Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
-
Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P (2011) Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output. Blood.
-
(2011)
Blood
-
-
Ballmer-Hofer, K.1
Andersson, A.E.2
Ratcliffe, L.E.3
Berger, P.4
|