메뉴 건너뛰기




Volumn 65, Issue 4, 2013, Pages 491-503

Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties

Author keywords

5 Fluorouracil; Antitumor drug resistance; Doxorubicin; Hepatic cancer stem cells; Hepatocellular carcinoma

Indexed keywords

ALPHA FETOPROTEIN; CD133 ANTIGEN; CD19 ANTIGEN; CD56 ANTIGEN; DOXORUBICIN; EPITHELIAL CELL ADHESION MOLECULE; FLUOROURACIL; MICROSOMAL AMINOPEPTIDASE; OCTAMER TRANSCRIPTION FACTOR 4; RHODAMINE 123; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

EID: 84881161146     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-012-9511-9     Document Type: Article
Times cited : (27)

References (103)
  • 1
    • 77953170540 scopus 로고    scopus 로고
    • CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance
    • 10.1158/0008-5472.CAN-09-3463 1:CAS:528:DC%2BC3cXmslWgtLs%3D
    • Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, Iwakuma T (2010) CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 70:4602-4612
    • (2010) Cancer Res , vol.70 , pp. 4602-4612
    • Adhikari, A.S.1    Agarwal, N.2    Wood, B.M.3    Porretta, C.4    Ruiz, B.5    Pochampally, R.R.6    Iwakuma, T.7
  • 3
    • 47749116454 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells
    • 10.1074/jbc.M800109200 1:CAS:528:DC%2BD1cXntFSmsrw%3D
    • Bourguignon LY, Peyrollier K, Xia W, Gilad E (2008) Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem 283:17635-17651
    • (2008) J Biol Chem , vol.283 , pp. 17635-17651
    • Bourguignon, L.Y.1    Peyrollier, K.2    Xia, W.3    Gilad, E.4
  • 5
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • 10.1016/S0092-8674(03)00392-1
    • Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 5:643-655
    • (2003) Cell , vol.5 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 7
    • 84861193535 scopus 로고    scopus 로고
    • MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells
    • 10.1111/j.1742-4658.2012.08589.x 1:CAS:528:DC%2BC38Xpt1equr0%3D
    • Cheng W, Liu T, Wan X, Gao Y, Wang H (2012) MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells. FEBS J 279:2047-2059
    • (2012) FEBS J , vol.279 , pp. 2047-2059
    • Cheng, W.1    Liu, T.2    Wan, X.3    Gao, Y.4    Wang, H.5
  • 9
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • 10.1002/hep.21227 1:CAS:528:DC%2BD28XnsFWjur0%3D
    • Chiba T, Kita K, Zheng YW, Yokosuka O, Saisho H, Iwama A, Nakauchi H, Taniguchi H (2006) Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44:240-251
    • (2006) Hepatology , vol.44 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.W.3    Yokosuka, O.4    Saisho, H.5    Iwama, A.6    Nakauchi, H.7    Taniguchi, H.8
  • 12
    • 77950810261 scopus 로고    scopus 로고
    • Comparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC)
    • Dhanasekaran R, Kooby DA, Staley CA, Kauh JS, Khanna V, Kim HS (2010) Comparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC). J Surg Oncol 101:476-480
    • (2010) J Surg Oncol , vol.101 , pp. 476-480
    • Dhanasekaran, R.1    Kooby, D.A.2    Staley, C.A.3    Kauh, J.S.4    Khanna, V.5    Kim, H.S.6
  • 13
    • 0028862265 scopus 로고
    • Epirubicin, cisplatin and infusional 5-fluorouracil (5-FU) (ECF) in hepatobiliary tumours
    • 10.1016/0959-8049(95)00323-B
    • Ellis PA, Norman A, Hill A, O'Brien ME, Nicolson M, Hickish T, Cunningham D (1995) Epirubicin, cisplatin and infusional 5-fluorouracil (5-FU) (ECF) in hepatobiliary tumours. Eur J Cancer 10:1594-1598
    • (1995) Eur J Cancer , vol.10 , pp. 1594-1598
    • Ellis, P.A.1    Norman, A.2    Hill, A.3    O'Brien, M.E.4    Nicolson, M.5    Hickish, T.6    Cunningham, D.7
  • 14
    • 72449142264 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-alpha for the treatment of advanced hepatocellular carcinoma with portal vein tumor thrombosis
    • 10.3109/00365520903367262
    • Eun JR, Lee HJ, Moon HJ, Kim TN, Kim JW, Chang JC (2009) Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-alpha for the treatment of advanced hepatocellular carcinoma with portal vein tumor thrombosis. Scand J Gastroenterol 44:1477-1486
    • (2009) Scand J Gastroenterol , vol.44 , pp. 1477-1486
    • Eun, J.R.1    Lee, H.J.2    Moon, H.J.3    Kim, T.N.4    Kim, J.W.5    Chang, J.C.6
  • 17
    • 79959517589 scopus 로고    scopus 로고
    • Comparison of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma
    • 10.1016/j.rx.2010.07.010 1:STN:280:DC%2BC3MjltFKltQ%3D%3D
    • Ferrer Puchol MD, la Parra C, Esteban E, Vaño M, Forment M, Vera A, Cosín O (2011) Comparison of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma. Radiologia 53:246-253
    • (2011) Radiologia , vol.53 , pp. 246-253
    • Ferrer Puchol, M.D.1    La Parra, C.2    Esteban, E.3    Vaño, M.4    Forment, M.5    Vera, A.6    Cosín, O.7
  • 18
    • 0028085089 scopus 로고
    • The kit ligand, stem cell factor
    • 10.1016/S0065-2776(08)60508-8 1:CAS:528:DyaK2cXkt1Kqtrg%3D
    • Galli SJ, Zsebo KM, Geissler EN (1994) The kit ligand, stem cell factor. Adv Immunol 55:1-96
    • (1994) Adv Immunol , vol.55 , pp. 1-96
    • Galli, S.J.1    Zsebo, K.M.2    Geissler, E.N.3
  • 19
    • 0025828970 scopus 로고
    • Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter
    • 10.1007/BF01232978 1:CAS:528:DyaK3MXit1als7o%3D
    • Geissler EN, Liao M, Brook JD (1991) Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet 17:207-214
    • (1991) Somat Cell Mol Genet , vol.17 , pp. 207-214
    • Geissler, E.N.1    Liao, M.2    Brook, J.D.3
  • 20
    • 0013243216 scopus 로고    scopus 로고
    • Stem cell identification and sorting using the Hoeschst 33342 side population (SP)
    • unit 9.18
    • Goodell MA (2001) Stem cell identification and sorting using the Hoeschst 33342 side population (SP). In: Current protocols in cytometry, unit 9.18
    • (2001) Current Protocols in Cytometry
    • Goodell, M.A.1
  • 21
    • 80054937192 scopus 로고    scopus 로고
    • Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas
    • 10.1111/j.1365-2559.2011.03993.x
    • Guo Y, Liu S, Wang P, Zhao S, Wang F, Bing L, Zhang Y, Ling EA, Gao J, Hao A (2011) Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology 4:763-775
    • (2011) Histopathology , vol.4 , pp. 763-775
    • Guo, Y.1    Liu, S.2    Wang, P.3    Zhao, S.4    Wang, F.5    Bing, L.6    Zhang, Y.7    Ling, E.A.8    Gao, J.9    Hao, A.10
  • 23
    • 18844392836 scopus 로고    scopus 로고
    • Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues
    • 10.1016/j.cell.2005.02.018
    • Hochedlinger K, Yamada Y, Beard C, Jaenisch R (2005) Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 3:465-477
    • (2005) Cell , vol.3 , pp. 465-477
    • Hochedlinger, K.1    Yamada, Y.2    Beard, C.3    Jaenisch, R.4
  • 24
    • 0033854015 scopus 로고    scopus 로고
    • Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer
    • 10.1053/jhep.2000.9409 1:CAS:528:DC%2BD3cXlvVyjtrk%3D
    • Ikeda K, Arase Y, Saitoh S, Kobayashi M, Suzuki Y, Suzuki F, Tsubota A, Chayama K, Murashima N, Kumada H (2000) Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology 32:228-232
    • (2000) Hepatology , vol.32 , pp. 228-232
    • Ikeda, K.1    Arase, Y.2    Saitoh, S.3    Kobayashi, M.4    Suzuki, Y.5    Suzuki, F.6    Tsubota, A.7    Chayama, K.8    Murashima, N.9    Kumada, H.10
  • 25
    • 84860367617 scopus 로고    scopus 로고
    • EpCAM and its potential role in tumor-initiating cells
    • 10.4161/cam.18953
    • Imrich S, Hachmeister M, Gires O (2012) EpCAM and its potential role in tumor-initiating cells. Cell Adh Migr 6:30-38
    • (2012) Cell Adh Migr , vol.6 , pp. 30-38
    • Imrich, S.1    Hachmeister, M.2    Gires, O.3
  • 26
    • 84860752172 scopus 로고    scopus 로고
    • Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145
    • Jia Y, Liu H, Zhuang Q, Xu S, Yang Z, Li J, Lou J, Zhang W (2012) Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol Rep 6:1865-1872
    • (2012) Oncol Rep , vol.6 , pp. 1865-1872
    • Jia, Y.1    Liu, H.2    Zhuang, Q.3    Xu, S.4    Yang, Z.5    Li, J.6    Lou, J.7    Zhang, W.8
  • 27
    • 0344011434 scopus 로고    scopus 로고
    • Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis
    • 1:CAS:528:DC%2BD3sXpsFGju7w%3D
    • Kim M, Morshead CM (2003) Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis. J Neurosci 23:10703-10709
    • (2003) J Neurosci , vol.23 , pp. 10703-10709
    • Kim, M.1    Morshead, C.M.2
  • 29
    • 0033652599 scopus 로고    scopus 로고
    • Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus-an hepatocellular carcinoma differ according to infected hepatitis virus-an analysis of 236 consecutive patients with a single lesion
    • 10.1053/jhep.2000.20237 1:STN:280:DC%2BD3M%2FntFegsA%3D%3D
    • Koike Y, Shiratori Y, Sato S, Obi S, Teratani T, Imamura M, Hamamura K, Imai Y, Yoshida H, Shiina S, Omata M (2000) Risk factors for recurring hepatocellular carcinoma differ according to infected hepatitis virus-an hepatocellular carcinoma differ according to infected hepatitis virus-an analysis of 236 consecutive patients with a single lesion. Hepatology 32:1216-1223
    • (2000) Hepatology , vol.32 , pp. 1216-1223
    • Koike, Y.1    Shiratori, Y.2    Sato, S.3    Obi, S.4    Teratani, T.5    Imamura, M.6    Hamamura, K.7    Imai, Y.8    Yoshida, H.9    Shiina, S.10    Omata, M.11
  • 30
    • 33845499286 scopus 로고    scopus 로고
    • Stem cell factor levels do increase in patients subsequent to hepatectomy with the extent of parenchymal loss
    • 10.1016/j.transproceed.2006.10.111 1:CAS:528:DC%2BD28XhtlarsbbN
    • Krieg A, Schulte Am EJ, Schmelzle M (2006) Stem cell factor levels do increase in patients subsequent to hepatectomy with the extent of parenchymal loss. Transplant Proc 38:3556-3558
    • (2006) Transplant Proc , vol.38 , pp. 3556-3558
    • Krieg, A.1    Schulte Am, E.J.2    Schmelzle, M.3
  • 31
    • 0035872948 scopus 로고    scopus 로고
    • Effects of long-term postoperative interferonalpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial
    • 10.7326/0003-4819-134-10-200105150-00010 1:CAS:528:DC%2BD3MXktF2gs70%3D
    • Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Yamazaki O, Shiomi S, Tamori A, Oka H, Igawa S, Kuroki T, Kinoshita H (2001) Effects of long-term postoperative interferonalpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial. Ann Intern Med 134:963-967
    • (2001) Ann Intern Med , vol.134 , pp. 963-967
    • Kubo, S.1    Nishiguchi, S.2    Hirohashi, K.3    Tanaka, H.4    Shuto, T.5    Yamazaki, O.6    Shiomi, S.7    Tamori, A.8    Oka, H.9    Igawa, S.10    Kuroki, T.11    Kinoshita, H.12
  • 34
    • 0023765990 scopus 로고    scopus 로고
    • Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial
    • Lai CL, Wu PC, Chan GC, Lok AS, Lin HJ (1998) Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial. Cancer 3:479-483
    • (1998) Cancer , vol.3 , pp. 479-483
    • Lai, C.L.1    Wu, P.C.2    Chan, G.C.3    Lok, A.S.4    Lin, H.J.5
  • 35
    • 60549083706 scopus 로고    scopus 로고
    • Inhibition of CD44 expression by small interfering RNA to suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo
    • 1:CAS:528:DC%2BD1cXjtlygs7s%3D
    • Li CZ, Liu B, Wen ZQ, Li HY (2008) Inhibition of CD44 expression by small interfering RNA to suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo. Folia Biol (Praha) 6:180-186
    • (2008) Folia Biol (Praha) , vol.6 , pp. 180-186
    • Li, C.Z.1    Liu, B.2    Wen, Z.Q.3    Li, H.Y.4
  • 36
    • 78049303163 scopus 로고    scopus 로고
    • Downregulation of ABCG2 expression in glioblastoma cancer stem cells with miRNA-328 may decrease their chemoresistance
    • Li WQ, Li YM, Tao BB, Lu YC, Hu GH, Liu HM, He J, Xu Y, Yu HY (2010) Downregulation of ABCG2 expression in glioblastoma cancer stem cells with miRNA-328 may decrease their chemoresistance. Med Sci Monit 10:HY27-HY30
    • (2010) Med Sci Monit , vol.10
    • Li, W.Q.1    Li, Y.M.2    Tao, B.B.3    Lu, Y.C.4    Hu, G.H.5    Liu, H.M.6    He, J.7    Xu, Y.8    Yu, H.Y.9
  • 37
    • 0030867119 scopus 로고    scopus 로고
    • Non-surgical treatment of hepatocellular carcinoma
    • 10.1111/j.1440-1746.1997.tb00516.x 1:CAS:528:DyaK2sXnvFKqurw%3D
    • Lin DY, Lin SM, Liaw YF (1997) Non-surgical treatment of hepatocellular carcinoma. J Gastroenterol Hepatol 12:S319-S328
    • (1997) J Gastroenterol Hepatol , vol.12
    • Lin, D.Y.1    Lin, S.M.2    Liaw, Y.F.3
  • 38
    • 84863729298 scopus 로고    scopus 로고
    • Co-expression of Oct-4 and Nestin in human breast cancers
    • 10.1007/s11033-011-1398-6 1:CAS:528:DC%2BC38XksVChtLY%3D
    • Liu C, Cao X, Zhang Y, Xu H, Zhang R, Wu Y, Lu P, Jin F (2012) Co-expression of Oct-4 and Nestin in human breast cancers. Mol Biol Rep 39:5875-5881
    • (2012) Mol Biol Rep , vol.39 , pp. 5875-5881
    • Liu, C.1    Cao, X.2    Zhang, Y.3    Xu, H.4    Zhang, R.5    Wu, Y.6    Lu, P.7    Jin, F.8
  • 39
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 40
    • 0032879468 scopus 로고    scopus 로고
    • Prognsis of hepatocellular carcinoma: The BCLC staging classification
    • 10.1055/s-2007-1007122 1:STN:280:DyaK1Mvks1Grsg%3D%3D
    • Llovet JM, Bru C, Bruix J (1999) Prognsis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19:329-338
    • (1999) Semin Liver Dis , vol.19 , pp. 329-338
    • Llovet, J.M.1    Bru, C.2    Bruix, J.3
  • 41
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • 10.1053/j.gastro.2007.04.025 1:CAS:528:DC%2BD2sXnvFOgsr4%3D
    • Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY (2007) Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132:2542-2556
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6    Zheng, B.J.7    Guan, X.Y.8
  • 42
    • 51649119918 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    • 10.1158/1541-7786.MCR-08-0035 1:CAS:528:DC%2BD1cXoslCgtrc%3D
    • Ma S, Chan KW, Lee TK, Tang KH, Wo JY, Zheng BJ, Guan XY (2008) Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 6:1146-1153
    • (2008) Mol Cancer Res , vol.6 , pp. 1146-1153
    • Ma, S.1    Chan, K.W.2    Lee, T.K.3    Tang, K.H.4    Wo, J.Y.5    Zheng, B.J.6    Guan, X.Y.7
  • 43
    • 25444517339 scopus 로고    scopus 로고
    • Identification of novel resident pulmonary stem cells: Form and function of the lung side population
    • 10.1634/stemcells.2005-0039
    • Majka SM, Beutz MA, Hagen M, Izzo AA, Voelkel N, Helm KM (2005) Identification of novel resident pulmonary stem cells: form and function of the lung side population. Stem Cells 23:1073-1081
    • (2005) Stem Cells , vol.23 , pp. 1073-1081
    • Majka, S.M.1    Beutz, M.A.2    Hagen, M.3    Izzo, A.A.4    Voelkel, N.5    Helm, K.M.6
  • 44
    • 65649140491 scopus 로고    scopus 로고
    • Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma
    • 10.1038/labinvest.2009.15 1:CAS:528:DC%2BD1MXltV2hur4%3D
    • Mansuroglu T, Ramadori P, Dudás J, Malik I, Hammerich K, Füzesi L, Ramadori G (2009) Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma. Lab Invest 89:562-574
    • (2009) Lab Invest , vol.89 , pp. 562-574
    • Mansuroglu, T.1    Ramadori, P.2    Dudás, J.3    Malik, I.4    Hammerich, K.5    Füzesi, L.6    Ramadori, G.7
  • 45
    • 4344657061 scopus 로고    scopus 로고
    • Silent right ventricular myocardial infarction: The Q wave never lies
    • 10.1136/hrt.2003.032789 1:STN:280:DC%2BD2cvgs1aqtw%3D%3D
    • Martin TN, Dargie H (2004) Silent right ventricular myocardial infarction: the Q wave never lies. Heart 90:1002
    • (2004) Heart , vol.90 , pp. 1002
    • Martin, T.N.1    Dargie, H.2
  • 46
    • 0642370769 scopus 로고    scopus 로고
    • Concentration of 5-FU after hepatic artery infusion chemotherapy for liver metastases of colorectal cancer
    • Maruyama S, Ando M, Watayo T (2003) Concentration of 5-FU after hepatic artery infusion chemotherapy for liver metastases of colorectal cancer. Gan To Kagaku Ryoho 30:1635-1638
    • (2003) Gan to Kagaku Ryoho , vol.30 , pp. 1635-1638
    • Maruyama, S.1    Ando, M.2    Watayo, T.3
  • 49
    • 78649648616 scopus 로고    scopus 로고
    • In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2)
    • 10.1007/978-3-642-14541-4-9 1:CAS:528:DC%2BC3MXmsFWrs7k%3D
    • Meyer zu Schwabedissen HE, Kroemer HK (2011) In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol 201:325-371
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 325-371
    • Meyer Zu Schwabedissen, H.E.1    Kroemer, H.K.2
  • 50
    • 84863143391 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • Mikhail S, He AR (2011) Liver cancer stem cells. Int J Hepatol 2011:486954
    • (2011) Int J Hepatol , vol.2011 , pp. 486954
    • Mikhail, S.1    He, A.R.2
  • 51
    • 0037806031 scopus 로고    scopus 로고
    • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    • 10.1016/S0092-8674(03)00393-3 1:CAS:528:DC%2BD3sXksFehur4%3D
    • Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642
    • (2003) Cell , vol.113 , pp. 631-642
    • Mitsui, K.1    Tokuzawa, Y.2    Itoh, H.3    Segawa, K.4    Murakami, M.5    Takahashi, K.6    Maruyama, M.7    Maeda, M.8    Yamanaka, S.9
  • 52
    • 79952993517 scopus 로고    scopus 로고
    • Multidrug efflux pumps and cancer stem cells: Insights into multidrug resistance and therapeutic development
    • 10.1038/clpt.2011.14 1:CAS:528:DC%2BC3MXjs1Clsrs%3D
    • Moitra K, Lou H, Dean M (2011) Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development. Clin Pharmacol Ther 89:491-502
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 491-502
    • Moitra, K.1    Lou, H.2    Dean, M.3
  • 53
    • 0042424676 scopus 로고    scopus 로고
    • Skeletal muscle engraftment potential of adult mouse skin side population cells
    • 10.1073/pnas.1133179100 1:CAS:528:DC%2BD3sXmtlyktL4%3D
    • Montanaro F, Liadaki K, Volinski J, Flint A, Kunkel LM (2003) Skeletal muscle engraftment potential of adult mouse skin side population cells. Proc Natl Acad Sci USA 100:9336-9341
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9336-9341
    • Montanaro, F.1    Liadaki, K.2    Volinski, J.3    Flint, A.4    Kunkel, L.M.5
  • 54
    • 5844370499 scopus 로고    scopus 로고
    • Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma prevention study group
    • 10.1056/NEJM199606133342402 1:CAS:528:DyaK28XksVCgsLk%3D
    • Muto Y, Moriwaki H, Ninomiya M, Adachi S, Saito A, Takasaki KT, Tanaka T, Tsurumi K, Okuno M, Tomita E, Nakamura T, Kojima T (1996) Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma prevention study group. N Engl J Med 334:1561-1567
    • (1996) N Engl J Med , vol.334 , pp. 1561-1567
    • Muto, Y.1    Moriwaki, H.2    Ninomiya, M.3    Adachi, S.4    Saito, A.5    Takasaki, K.T.6    Tanaka, T.7    Tsurumi, K.8    Okuno, M.9    Tomita, E.10    Nakamura, T.11    Kojima, T.12
  • 55
    • 80455144217 scopus 로고    scopus 로고
    • Embolization of hepatocellular carcinoma with drug-eluting beads: Doxorubicin tissue concentration and distribution in patient liver explants
    • 10.1016/j.jhep.2011.03.024 1:CAS:528:DC%2BC3MXhsV2mt7zO
    • Namur J, Citron SJ, Sellers MT, Dupuis MH, Wassef M, Manfait M, Laurent A (2011) Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants. J Hepatol 55:1332-1338
    • (2011) J Hepatol , vol.55 , pp. 1332-1338
    • Namur, J.1    Citron, S.J.2    Sellers, M.T.3    Dupuis, M.H.4    Wassef, M.5    Manfait, M.6    Laurent, A.7
  • 56
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • 10.1038/74199 1:CAS:528:DC%2BD3cXisVCjsbo%3D
    • Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376
    • (2000) Nat Genet , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 58
    • 34250888086 scopus 로고    scopus 로고
    • Repetitive short-course hepatic arterial infusion chemotherapy with high-dose 5-fluorouracil and cisplatin in patients with advanced hepatocellular carcinoma
    • 10.1002/cncr.22759
    • Park JY, Ahn SH, Yoon YJ, Kim JK, Lee HW, Lee do Y, Chon CY, Moon YM, Han KH (2007) Repetitive short-course hepatic arterial infusion chemotherapy with high-dose 5-fluorouracil and cisplatin in patients with advanced hepatocellular carcinoma. Cancer 110:129-137
    • (2007) Cancer , vol.110 , pp. 129-137
    • Park, J.Y.1    Ahn, S.H.2    Yoon, Y.J.3    Kim, J.K.4    Lee, H.W.5    Lee Do, Y.6    Chon, C.Y.7    Moon, Y.M.8    Han, K.H.9
  • 59
    • 22244433866 scopus 로고    scopus 로고
    • Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    • 10.1158/0008-5472.CAN-05-0592 1:CAS:528:DC%2BD2MXmt1egsrk%3D
    • Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG (2005) Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res 65:6207-6219
    • (2005) Cancer Res , vol.65 , pp. 6207-6219
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3    Zhou, J.4    Claypool, K.5    Tang, D.G.6
  • 60
    • 78650122336 scopus 로고    scopus 로고
    • Dynamic versus static ABCG2 inhibitors to sensitize drug resistant cancer cells
    • 10.1371/journal.pone.0015276
    • Peng H, Qi J, Dong Z, Zhang JT (2010) Dynamic versus static ABCG2 inhibitors to sensitize drug resistant cancer cells. PLoS ONE 5:e15276
    • (2010) PLoS ONE , vol.5 , pp. 15276
    • Peng, H.1    Qi, J.2    Dong, Z.3    Zhang, J.T.4
  • 63
    • 79955904096 scopus 로고    scopus 로고
    • Differentiating of banked human umbilical cord blood-derived mesenchymal stem cells into insulin-secreting cells
    • 10.1007/s11626-010-9356-5 1:CAS:528:DC%2BC3MXht1entL4%3D
    • Phuc PV, Nhung TH, Loan DT, Chung DC, Ngoc PK (2011) Differentiating of banked human umbilical cord blood-derived mesenchymal stem cells into insulin-secreting cells. In Vitro Cell Dev Biol Anim 47:54-63
    • (2011) Vitro Cell Dev Biol Anim , vol.47 , pp. 54-63
    • Phuc, P.V.1    Nhung, T.H.2    Loan, D.T.3    Chung, D.C.4    Ngoc, P.K.5
  • 65
    • 84856680480 scopus 로고    scopus 로고
    • Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis
    • 10.1245/s10434-011-2132-2
    • Pilati P, Mocellin S, Bertazza L, Galdi F, Briarava M, Mammano E, Tessari E, Zavagno G, Nitti D (2012) Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis. Ann Surg Oncol 19:402-408
    • (2012) Ann Surg Oncol , vol.19 , pp. 402-408
    • Pilati, P.1    Mocellin, S.2    Bertazza, L.3    Galdi, F.4    Briarava, M.5    Mammano, E.6    Tessari, E.7    Zavagno, G.8    Nitti, D.9
  • 66
    • 84866707150 scopus 로고    scopus 로고
    • Safety and feasibility of same-day discharge of patients with unresectable hepatocellular carcinoma treated with doxorubicin drug-eluting bead transcatheter chemoembolization
    • 10.1016/j.jvir.2012.07.003
    • Prajapati HJ, Rafi S, El-Rayes BF, Kauh JS, Kooby DA, Kim HS (2012) Safety and feasibility of same-day discharge of patients with unresectable hepatocellular carcinoma treated with doxorubicin drug-eluting bead transcatheter chemoembolization. J Vasc Interv Radiol 23:1286-1293
    • (2012) J Vasc Interv Radiol , vol.23 , pp. 1286-1293
    • Prajapati, H.J.1    Rafi, S.2    El-Rayes, B.F.3    Kauh, J.S.4    Kooby, D.A.5    Kim, H.S.6
  • 67
    • 33644752698 scopus 로고    scopus 로고
    • Stem cell factor and its receptor c-kit as targets for inflammatory diseases
    • 10.1016/j.ejphar.2005.12.067 1:CAS:528:DC%2BD28XitVKgs7g%3D
    • Reber L, Da Silva CA, Frossard N (2006) Stem cell factor and its receptor c-kit as targets for inflammatory diseases. Eur J Pharmacol 533:327-340
    • (2006) Eur J Pharmacol , vol.533 , pp. 327-340
    • Reber, L.1    Da Silva, C.A.2    Frossard, N.3
  • 70
    • 70349912085 scopus 로고    scopus 로고
    • Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models
    • 10.4161/cc.8.19.9758 1:CAS:528:DC%2BC3cXmslKms7k%3D
    • Sabisz M, Skladanowski A (2009) Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models. Cell Cycle 8:3208-3217
    • (2009) Cell Cycle , vol.8 , pp. 3208-3217
    • Sabisz, M.1    Skladanowski, A.2
  • 72
    • 84859577135 scopus 로고    scopus 로고
    • Hepatocellular carcinoma stem cells: Origins and roles in hepatocarcinogenesis and disease progression
    • Shen Y, Cao D (2012) Hepatocellular carcinoma stem cells: origins and roles in hepatocarcinogenesis and disease progression. Front Biosci (Elite Ed) 4:1157-1169
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 1157-1169
    • Shen, Y.1    Cao, D.2
  • 73
    • 0037327686 scopus 로고    scopus 로고
    • Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury
    • 1:CAS:528:DC%2BD3sXht1Cmtrs%3D
    • Simpson K, Hogaboam CM, Kunkel SL (2003) Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab Invest 83:199-206
    • (2003) Lab Invest , vol.83 , pp. 199-206
    • Simpson, K.1    Hogaboam, C.M.2    Kunkel, S.L.3
  • 74
    • 0024009418 scopus 로고
    • 5-FU and HCFU concentrations in serum and tissues in hepatocellular carcinoma after HCFU oral administration
    • 1:STN:280:DyaL1c3ksFGitA%3D%3D
    • Suenaga M (1988) 5-FU and HCFU concentrations in serum and tissues in hepatocellular carcinoma after HCFU oral administration. Gan No Rinsho 34:744-748
    • (1988) Gan No Rinsho , vol.34 , pp. 744-748
    • Suenaga, M.1
  • 75
    • 33750809196 scopus 로고    scopus 로고
    • Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
    • 10.1016/j.bbrc.2006.10.128 1:CAS:528:DC%2BD28Xht1CqtrzK
    • Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T, Moriwaki H (2006) Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun 351:820-824
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 820-824
    • Suetsugu, A.1    Nagaki, M.2    Aoki, H.3    Motohashi, T.4    Kunisada, T.5    Moriwaki, H.6
  • 76
    • 33645772227 scopus 로고    scopus 로고
    • Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
    • 10.1016/j.ccr.2006.03.003 1:CAS:528:DC%2BD28XjvFeiuro%3D
    • Sun L, Hui AM, Su Q (2006) Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 9:287-300
    • (2006) Cancer Cell , vol.9 , pp. 287-300
    • Sun, L.1    Hui, A.M.2    Su, Q.3
  • 78
    • 75549088882 scopus 로고    scopus 로고
    • EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma
    • 10.1016/j.jhep.2009.10.026 1:CAS:528:DC%2BC3cXhs1artL4%3D
    • Terris B, Cavard C, Perret C (2010) EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma. J Hepatol 52:280-281
    • (2010) J Hepatol , vol.52 , pp. 280-281
    • Terris, B.1    Cavard, C.2    Perret, C.3
  • 79
    • 77957663369 scopus 로고    scopus 로고
    • Leukemia stem cells and new strategies to overcome resistance to therapy
    • 10.2174/157488810791824485 1:CAS:528:DC%2BC3cXhtFertb%2FM
    • Thomas X, Cannas G (2010) Leukemia stem cells and new strategies to overcome resistance to therapy. Curr Stem Cell Res Ther 5:277-286
    • (2010) Curr Stem Cell Res Ther , vol.5 , pp. 277-286
    • Thomas, X.1    Cannas, G.2
  • 80
    • 79953789525 scopus 로고    scopus 로고
    • Revisiting the ABCs of multidrug resistance in cancer chemotherapy
    • 10.2174/138920111795164048 1:CAS:528:DC%2BC3MXls1OhsLo%3D
    • Tiwari AK, Sodani K, Dai CL, Ashby CR Jr, Chen ZS (2011) Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Curr Pharm Biotechnol 12:570-594
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 570-594
    • Tiwari, A.K.1    Sodani, K.2    Dai, C.L.3    Ashby Jr., C.R.4    Chen, Z.S.5
  • 81
    • 79960805359 scopus 로고    scopus 로고
    • Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma
    • 10.1111/j.1600-0714.2011.01015.x 1:CAS:528:DC%2BC3MXht1ymsrnO
    • Tsai LL, Yu CC, Chang YC, Yu CH, Chou MY (2011) Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med 40:621-628
    • (2011) J Oral Pathol Med , vol.40 , pp. 621-628
    • Tsai, L.L.1    Yu, C.C.2    Chang, Y.C.3    Yu, C.H.4    Chou, M.Y.5
  • 83
    • 61449234114 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma
    • 10.1007/s00280-008-0817-4 1:CAS:528:DC%2BD1MXitlWhsb8%3D
    • Uhm JE, Park JO, Lee J, Park YS, Park SH, Yoo BC, Paik SW, Koh KC, Kang WK, Lim HY (2009) A phase II study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma. Cancer Chemother Pharmacol 63:929-935
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 929-935
    • Uhm, J.E.1    Park, J.O.2    Lee, J.3    Park, Y.S.4    Park, S.H.5    Yoo, B.C.6    Paik, S.W.7    Koh, K.C.8    Kang, W.K.9    Lim, H.Y.10
  • 84
    • 24644458808 scopus 로고    scopus 로고
    • The sural artery perforator flap for coverage of defects of the knee and tibia
    • 10.1080/02844310410004964
    • Umemoto Y, Adachi Y, Ebisawa K (2005) The sural artery perforator flap for coverage of defects of the knee and tibia. Scand J Plast Reconstr Surg Hand Surg 39:209-212
    • (2005) Scand J Plast Reconstr Surg Hand Surg , vol.39 , pp. 209-212
    • Umemoto, Y.1    Adachi, Y.2    Ebisawa, K.3
  • 87
    • 84862264948 scopus 로고    scopus 로고
    • Targeting prostate cancer stem cells for cancer therapy
    • 10.1038/nbt.2112
    • Wang G, Wang Z, Sarkar FH, Wei W (2012) Targeting prostate cancer stem cells for cancer therapy. Discov Med 13:135-142
    • (2012) Discov Med , vol.13 , pp. 135-142
    • Wang, G.1    Wang, Z.2    Sarkar, F.H.3    Wei, W.4
  • 88
    • 0346244093 scopus 로고    scopus 로고
    • Isolation and characterization of functional mammary gland stem cells
    • 10.1046/j.1365-2184.36.s.1.3.x 1:CAS:528:DC%2BD3sXpsFChtr8%3D
    • Welm B, Behbod F, Goodell MA, Rosen JM (2003) Isolation and characterization of functional mammary gland stem cells. Cell Prolif 36:17-32
    • (2003) Cell Prolif , vol.36 , pp. 17-32
    • Welm, B.1    Behbod, F.2    Goodell, M.A.3    Rosen, J.M.4
  • 89
    • 77954251791 scopus 로고    scopus 로고
    • World Health Organisation No. 207. February 2006
    • World Health Organisation (2006) Cancer fact sheet, No. 207. February 2006
    • (2006) Cancer Fact Sheet
  • 90
    • 0037738561 scopus 로고    scopus 로고
    • Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells
    • Wulf GG, Luo KL, Jackson KA, Brenner MK, Goodell MA (2003) Cells of the hepatic side population contribute to liver regeneration and can be replenished with bone marrow stem cells. Haematologica 88:368-378
    • (2003) Haematologica , vol.88 , pp. 368-378
    • Wulf, G.G.1    Luo, K.L.2    Jackson, K.A.3    Brenner, M.K.4    Goodell, M.A.5
  • 91
    • 77649196191 scopus 로고    scopus 로고
    • The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor
    • 10.1093/carcin/bgp232 1:CAS:528:DC%2BC3cXhsVWjurs%3D
    • Xu XL, Xing BC, Han HB, Zhao W, Hu MH, Xu ZL, Li JY, Xie Y, Gu J, Wang Y, Zhang ZQ (2010) The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. Carcinogenesis 31:167-174
    • (2010) Carcinogenesis , vol.31 , pp. 167-174
    • Xu, X.L.1    Xing, B.C.2    Han, H.B.3    Zhao, W.4    Hu, M.H.5    Xu, Z.L.6    Li, J.Y.7    Xie, Y.8    Gu, J.9    Wang, Y.10    Zhang, Z.Q.11
  • 92
    • 84864681330 scopus 로고    scopus 로고
    • Current status of hepatocellular carcinoma treatment in Japan: Hepatic arterial infusion chemotherapy
    • 1:CAS:528:DC%2BC38XhsVKjtbfM
    • Yamashita T (2012) Current status of hepatocellular carcinoma treatment in Japan: hepatic arterial infusion chemotherapy. Clin Drug Investig 32:15-23
    • (2012) Clin Drug Investig , vol.32 , pp. 15-23
    • Yamashita, T.1
  • 93
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma
    • 10.1158/0008-5472.CAN-07-6013 1:CAS:528:DC%2BD1cXislagu78%3D
    • Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, Budhu A, Zanetti KA, Chen Y (2008) EpCAM and alpha-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma. Cancer Res 68:1451-1461
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3    Kim, J.W.4    Ye, Q.5    Jia, H.6    Budhu, A.7    Zanetti, K.A.8    Chen, Y.9
  • 94
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • 10.1053/j.gastro.2008.12.004 1:CAS:528:DC%2BD1MXjslSju78%3D
    • Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX (2009) EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136:1012-1024
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6    Jia, H.7    Ye, Q.8    Qin, L.X.9
  • 95
    • 84979823955 scopus 로고    scopus 로고
    • Expressions of CD34 and CD117 in human hepatocellular carcinomas and the clinical significance
    • 1:CAS:528:DC%2BC3MXhtlCqtbbF
    • Yan WW, Huang A, Li YG, Wang SS, Dai GH (2011) Expressions of CD34 and CD117 in human hepatocellular carcinomas and the clinical significance. Zhonghua Gan Zang Bing Za Zhi 19:588-593
    • (2011) Zhonghua Gan Zang Bing Za Zhi , vol.19 , pp. 588-593
    • Yan, W.W.1    Huang, A.2    Li, Y.G.3    Wang, S.S.4    Dai, G.H.5
  • 97
    • 34547830309 scopus 로고    scopus 로고
    • Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3 K/Akt pathway
    • 10.1007/s10620-007-9759-7 1:CAS:528:DC%2BD2sXoslGisLg%3D
    • Yasuda A, Sawai H, Takahashi H (2007) Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3 K/Akt pathway. Dig Dis Sci 52:2292-2300
    • (2007) Dig Dis Sci , vol.52 , pp. 2292-2300
    • Yasuda, A.1    Sawai, H.2    Takahashi, H.3
  • 99
    • 84856102517 scopus 로고    scopus 로고
    • The biology of cancer stem cells and its clinical implication in hepatocellular carcinoma
    • 10.5009/gnl.2012.6.1.29 1:CAS:528:DC%2BC38Xmt1ylsLk%3D
    • Yoon SK (2012) The biology of cancer stem cells and its clinical implication in hepatocellular carcinoma. Gut Liver 6:29-40
    • (2012) Gut Liver , vol.6 , pp. 29-40
    • Yoon, S.K.1
  • 100
    • 77957599212 scopus 로고    scopus 로고
    • Expression of Oct4 in HCC and modulation to wnt/β-catenin and TGF-β signal pathways
    • 10.1007/s11010-010-0509-3 1:CAS:528:DC%2BC3cXhtFOktb3E
    • Yuan F, Zhou W, Zou C, Zhang ZHuH, Dai Z, Zhang Y (2010) Expression of Oct4 in HCC and modulation to wnt/β-catenin and TGF-β signal pathways. Mol Cell Biochem 343:155-162
    • (2010) Mol Cell Biochem , vol.343 , pp. 155-162
    • Yuan, F.1    Zhou, W.2    Zou, C.3    Zhang, Z.4    Dai, Z.5    Zhang, Y.6
  • 102
    • 77949891635 scopus 로고    scopus 로고
    • Cancer stem/progenitor cells are highly enriched in CD133+ CD44+ population in hepatocellular carcinoma
    • 10.1002/ijc.24728 1:CAS:528:DC%2BC3cXisFemtLk%3D
    • Zhu Z, Hao X, Yan M, Yao M, Ge C, Gu J, Li J (2010) Cancer stem/progenitor cells are highly enriched in CD133+ CD44+ population in hepatocellular carcinoma. Int J Cancer 126:2067-2078
    • (2010) Int J Cancer , vol.126 , pp. 2067-2078
    • Zhu, Z.1    Hao, X.2    Yan, M.3    Yao, M.4    Ge, C.5    Gu, J.6    Li, J.7
  • 103
    • 79952116168 scopus 로고    scopus 로고
    • Analysis on the expression of the stem cells related genes in hepatocellular carcinoma cell lines
    • 1:CAS:528:DC%2BC3cXhsFyrtLk%3D
    • Zou C, Yuan FJ, Zhou WB, Huang L, Wang J, Zhang YS (2009) Analysis on the expression of the stem cells related genes in hepatocellular carcinoma cell lines. Zhonghua Gan Zang Bing Za Zhi 17:599-602
    • (2009) Zhonghua Gan Zang Bing Za Zhi , vol.17 , pp. 599-602
    • Zou, C.1    Yuan, F.J.2    Zhou, W.B.3    Huang, L.4    Wang, J.5    Zhang, Y.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.