Co-expression of Oct-4 and nestin in human breast cancers

Molecular Biology Reports

Volumn 39, Issue 5, 2012, Pages 5875-5881

  Liu, Caigang ^a   Cao, Xuezhao ^a   Zhang, Yanjun ^a   Xu, Hong ^b   Zhang, Ruishan ^b   Wu, Yunfei ^a   Lu, Ping ^a   Jin, Feng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Tumor Hospital of Liaoning Province   (China)

Author keywords

Breast cancer; Nestin; Oct 4; Stem cell; Survival

Indexed keywords

CD24 ANTIGEN; HERMES ANTIGEN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; POU5F1 PROTEIN, HUMAN;

ADULT; ARTICLE; BREAST CANCER; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOGENICITY; DISEASE ASSOCIATION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LYMPH NODE METASTASIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; BREAST TUMOR; CANCER STEM CELL; DEMOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; MULTICELLULAR SPHEROID; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; TUMOR CELL CULTURE; TUMOR GENE;

ADULT; ANTIGENS, CD24; ANTIGENS, CD44; BREAST NEOPLASMS; DEMOGRAPHY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASTIC STEM CELLS; NERVE TISSUE PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; PROPORTIONAL HAZARDS MODELS; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84863729298     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1398-6     Document Type: Article

References (16)

1. Zorzi M, Guzzinati S, Puliti D, Paci E (2010) A simple method to estimate the episode and programme sensitivity of breast cancer screening programmes. J Med Screen 17:132-138
2. Dowling EC, Klabunde C, Patnick J, Ballard-Barbash R; for the International Cancer Screening Network (ICSN) (2010) Breast and cervical cancer screening programme implementation in 16 countries. J Med Screen 17:139-146
3. Faghih Z, Erfani N, Razmkhah M, Sameni S, Talei A, Ghaderi A (2009) Interleukin13 haplotypes and susceptibility of Iranian women to breast cancer. Mol Biol Rep 36(7):1923-1928
4. Akisik E, Yazici H, Dalay N (2011) ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. Mol Biol Rep 38(1):343-348
5. Fabrizi E, di Martino S, Pelacchi F, Ricci-Vitiani L (2010) Therapeutic implications of colon cancer stem cells. World J Gastroenterol 16:3871-3877
6. Ginestier C, Charafe-Jauffret E, Birnbaum D (2010) Targeting breast cancer stem cells: fishing season open! Breast Cancer Res 12:312
7. Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF (2007) The prognostic role of a gene signature from tumorigenic breastcancer cells. N Engl J Med 356:217-226
8. Monsef N, Soller M, Isaksson M, Abrahamsson PA, Panagopoulos I (2009) The expression of pluripotency marker Oct 3/4 in prostate cancer and benign prostate hyperplasia. Prostate 69: 909-916
9. Park D, Xiang AP, Mao FF, Zhang L, Di CG, Liu XM, Shao Y, Ma BF, Lee JH, Ha KS, Walton N, Lahn BT (2010) Nestin is required for the proper self-renewal of neural stem cells. Stem Cells 28:2162-2171
10. Liu C, Chen B, Zhu J, Zhang R, Yao F, Jin F, Xu H, Lu P (2010) Clinical implications for nestin protein expression in breast cancer. Cancer Sci 101:815-819
11. Liu CG, Lu Y, Wang BB, Zhang YJ, Zhang RS, Lu Y, Chen B, Xu H, Jin F, Lu P (2011) Clinical implications of stem cell gene oct-4 expression in breast cancer. Ann Surg 253(6):1165-1171
12. Grimshaw MJ, Cooper L, Papazisis K, Coleman JA, Bohnenkamp HR, Chiapero-Stanke L, Taylor-Papadimitriou J, Burchell JM (2008) Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 10:R52
13. Tai MH, Chang CC, Kiupel M, Webster JD, Olson LK, Trosko JE (2005) Oct-4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 26:495-502
14. Naik RP, Jin D, Chuang E, Gold EG, Tousimis EA, Moore AL, Christos PJ, de Dalmas T, Donovan D, Rafii S, Vahdat LT (2008) Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer. Breast Cancer Res Treat 107:133-138
15. Guo J, Zhou J, Ying X, Men Y, Li RJ, Zhang Y, Du J, Tian W, Yao HJ, Wang XX, Ju RJ, Lu WL (2010) Effects of stealth liposomal daunorubicin plus tamoxifen on the breast cancer and cancer stem cells. J Pharm Pharm Sci 13:136-151
16. Li H, Cherukuri P, Li N, Cowling V, Spinella M, Cole M, Godwin AK, Wells W, DiRenzo J (2007) Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. Cancer Res 67:501-510