Minimizing the endophthalmitis rate following intravitreal injections using 0.25 % povidone-iodine irrigation and surgical mask

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 251, Issue 8, 2013, Pages 1885-1890

  Shimada, Hiroyuki ^a   Hattori, Takayuki ^a   Mori, Ryusaburo ^a   Nakashizuka, Hiroyuki ^a   Fujita, Kyoko ^a   Yuzawa, Mitsuko ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Bevacizumab; Conjunctival flora; Endophthalmitis; Eye drape; Eyelid speculum; Face mask; Intravitreal injection; Oral flora; Pegaptanib; Povidone iodine; Ranibizumab; Vascular endothelial growth factor

Indexed keywords

BEVACIZUMAB; LEVOFLOXACIN; PEGAPTANIB; POVIDONE IODINE; RANIBIZUMAB; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

ARTICLE; BACTERIAL FLORA; CONJUNCTIVA; DISINFECTION; DRUG EFFICACY; ENDOPHTHALMITIS; HOSPITAL DEPARTMENT; HUMAN; INFECTION CONTROL; INFECTION RATE; INJECTION SITE; JAPAN; LAVAGE; MAJOR CLINICAL STUDY; MEDICAL SPECIALIST; MICROFLORA; MOUTH CAVITY; NURSE; OUTPATIENT DEPARTMENT; PHYSICIAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL DRAPE; SURGICAL MASK; UNIVERSITY HOSPITAL; VITREOUS BODY;

ANGIOGENESIS INHIBITORS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIBODIES, MONOCLONAL, HUMANIZED; APTAMERS, NUCLEOTIDE; CONJUNCTIVA; ENDOPHTHALMITIS; EYE INFECTIONS, BACTERIAL; HUMANS; INTRAVITREAL INJECTIONS; LEVOFLOXACIN; MASKS; POVIDONE-IODINE; RETROSPECTIVE STUDIES; THERAPEUTIC IRRIGATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84881160968     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-013-2274-y     Document Type: Article

References (47)

1. Moss JM, Sanislo SR, Ta CN (2009) A prospective randomized evaluation of topical gatifloxacin on conjunctival flora in patients undergoing intravitreal injections. Ophthalmology 116:1498-1501
2. Stewart JM, Srivastava SK, Fung AE, Mahmoud TH, Telander DG, Hariprasad SM, Ober MD, Mruthyunjaya P (2011) Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study. Ocul Immunol Inflamm 19:32-38
3. Miño de Kaspar H, Chang RT, Singh K, Egbert PR, Blumenkranz MS, Ta CN (2005) Prospective randomized comparison of 2 different methods of 5 % povidone-iodine applications for anterior segment intraocular surgery. Arch Ophthalmol 123:161-165
4. Berkelman RL, Holland BW, Anderson RL (1982) Increased bactericidal activity of dilute preparations of povidone-iodine solutions. J Clin Microbiol 15:635-639
5. Jaffe GJ, Martin D, Callanan D, Pearson PA, Levy B, Comstock T, Fluocinolone Acetonide Uveitis Study Group (2006) Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. Ophthalmology 113:1020-1027
6. Shimada H, Arai S, Nakashizuka H, Hattori T, Yuzawa M (2011) Reduction of anterior chamber contamination rate after cataract surgery by intraoperative irrigation with 0.25 % povidone-iodine. Am J Ophthalmol 151:11-17
7. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M (2013) Reduction of vitreous contamination rate after 25-gauge vitrectomy by surface irrigation with 0.25 % povidone-iodine. Retina 33(1):143-151
8. Schimel AM, Scott IU, Flynn HW Jr (2011) Endophthalmitis after intravitreal injections: should the use of face masks be the standard of care? Arch Ophthalmol 129:1607-1609
9. McCannel CA (2011) Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents: causative organisms and possible prevention strategies. Retina 31:654-661
10. Doshi RR, Leng T, Fung AE (2012) Reducing oral flora contamination of intravitreal injection with face mask or silence. Retina 32:473-476
11. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, MARINA Study Group (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419-1431
12. Fung AE, Rosenfeld PJ, Reichel E (2006) The International Intravitreal Bevacizumab Safety Survey: using the internet to assess drug safety worldwide. Br J Ophthalmol 90:1344-1349
13. Singerman LJ, Masonson H, Patel M, Adamis AP, Buggage R, Cunningham E, Goldbaum M, Katz B, Guyer D (2008) Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial. Br J Ophthalmol 92:1606-1611
14. Fintak DR, Shah GK, Blinder KJ, Regillo CD, Pollack J, Heier JS, Hollands H, Sharma S (2008) Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina 28:1395-1399
15. Mason JO 3rd, White MF, Feist RM, Thomley ML, Albert MA, Persaud TO, Yunker JJ, Vail RS (2008) Incidence of acute onset endophthalmitis following intravitreal bevacizumab (Avastin) injection. Retina 28:564-567
16. Pilli S, Kotsolis A, Spaide RF, Slakter J, Freund KB, Sorenson J, Klancnik J, Cooney M (2008) Endophthalmitis associated with intravitreal anti-vascular endothelial growth factor therapy injections in an office setting. Am J Ophthalmol 145:879-882
17. Wu L, Martínez-Castellanos MA, Quiroz-Mercado H, Arevalo JF, Berrocal MH, Farah ME, Maia M, Roca JA, Rodriguez FJ, Pan American Collaborative Retina Group (PACORES) (2008) Twelve-month safety of intravitreal injections of bevacizumab (Avastin): results of the Pan-American Collaborative Retina Study Group (PACORES). Graefes Arch Clin Exp Ophthalmol 246:81-87
18. Diago T, McCannel CA, Bakri SJ, Pulido JS, Edwards AO, Pach JM (2009) Infectious endophthalmitis after intravitreal injection of antiangiogenic agents. Retina 29:601-605
19. Artunay O, Yuzbasioglu E, Rasier R, Sengül A, Bahcecioglu H (2009) Incidence and management of acute endophthalmitis after intravitreal bevacizumab (Avastin) injection. Eye (Lond) 23:2187-2193
20. Klein KS, Walsh MK, Hassan TS, Halperin LS, Castellarin AA, Roth D, Driscoll S, Prenner JL (2009) Endophthalmitis after anti-VEGF injections. Ophthalmology 116:1225
21. Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T, ANCHOR Study Group (2009) Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 116:57-65
22. Lima LH, Zweifel SA, Engelbert M, Sorenson JA, Slakter JS, Cooney MJ, Klancnik JM, Yannuzzi LA, Freund KB (2009) Evaluation of safety for bilateral same-day intravitreal injections of antivascular endothelial growth factor therapy. Retina 29:1213-1217
23. Bhavsar AR, Googe JM Jr, Stockdale CR, Bressler NM, Brucker AJ, Elman MJ, Glassman AR (2009) Diabetic Retinopathy Clinical Research Network. Risk of endophthalmitis after intravitreal drug injection when topical antibiotics are not required: the diabetic retinopathy clinical research network laser-ranibizumab-triamcinolone clinical trials. Arch Ophthalmol 127:1581-1583
24. Moshfeghi AA, Rosenfeld PJ, Flynn HW Jr, Schwartz SG, Davis JL, Murray TG, Smiddy WE, Berrocal AM, Dubovy SR, Lee WH, Albini TA, Lalwani GA, Kovach JL, Puliafito CA (2011) Endophthalmitis after intravitreal anti-vascular endothelial growth factor antagonists: a six-year experience at a university referral center. Retina 31:662-668
25. Inoue M, Kobayakawa S, Sotozono C, Komori H, Tanaka K, Suda Y, Matsushima H, Kinoshita S, Senoo T, Tochikubo T, Kadonosono K (2011) Evaluation of the incidence of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor. Ophthalmologica 226:145-150
26. Shah CP, Garg SJ, Vander JF, Brown GC, Kaiser RS, Haller JA, Post-Injection Endophthalmitis (PIE) Study Team (2011) Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. Ophthalmology 118:2028-2034
27. Inman ZD, Anderson NG (2011) Incidence of endophthalmitis after intravitreal injection of antivascular endothelial growth factor medications using topical lidocaine gel anesthesia. Retina 31:669-672
28. Chen E, Lin MY, Cox J, Brown DM (2011) Endophthalmitis after intravitreal injection: the importance of viridans streptococci. Retina 31:1525-1533
29. Bhatt SS, Stepien KE, Joshi K (2011) Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate. Retina 31:2032-2036
30. Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ; CATT Research Group (2011) Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med 364:1897-1908
31. Lad EM, Maltenfort MG, Leng T (2012) Effect of lidocaine gel anesthesia on endophthalmitis rates following intravitreal injection. Ophthalmic Surg Lasers Imaging 43:115-120
32. Cheung CS, Wong AW, Lui A, Kertes PJ, Devenyi RG, Lam WC (2012) Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections. Ophthalmology 119:1609-1614
33. Lundström M, Wejde G, Stenevi U, Thorburn W, Montan P (2007) Endophthalmitis after cataract surgery: a nationwide prospective study evaluating incidence in relation to incision type and location. Ophthalmology 114:866-870
34. Oshika T, Hatano H, Kuwayama Y, Ogura Y, Ohashi Y, Oki K, Uno T, Usui N, Yoshitomi F (2007) Incidence of endophthalmitis after cataract surgery in Japan. Acta Ophthalmol Scand 85:848-851
35. Doshi RR, Leng T, Fung AE (2011) Povidone-iodine before lidocaine gel anesthesia achieves surface antisepsis. Ophthalmic Surg Lasers Imaging 42:346-349
36. Wen JC, McCannel CA, Mochon AB, Garner OB (2011) Bacterial dispersal associated with speech in the setting of intravitreous injections. Arch Ophthalmol 129:1551-1554
37. Van den Broek PJ, Buys LF, Van Furth R (1982) Interaction of povidone-iodine compounds, phagocytic cells, and microorganisms. Antimicrob Agents Chemother 22:593-597
38. Jiang J, Wu M, Shen T (2009) The toxic effect of different concentrations of povidone iodine on the rabbit's cornea. Cutan Ocul Toxicol 28:119-124
39. Whitacre MM, Crockett RS (1990) Tolerance of intravitreal povidone-iodine in rabbit eyes. Curr Eye Res 9:725-732
40. Trost LW, Kivilcim M, Peyman GA, Aydin E, Kazi AA (2007) The effect of intravitreally injected povidone-iodine on Staphylococcus epidermidis in rabbit eyes. J Ocul Pharmacol Ther 23:70-77
41. Green-Simms AE, Ekdawi NS, Bakri SJ (2011) Survey of intravitreal injection techniques among retinal specialists in the United States. Am J Ophthalmol 151:329-332
42. Hyon JY, Eser I, O'Brien TP (2009) Kill rates of preserved and preservative-free topical 8-methoxy fluoroquinolones against various strains of Staphylococcus. J Cataract Refract Surg 35:1609-1613
43. Wykoff CC, Flynn HW Jr, Rosenfeld PJ (2011) Prophylaxis for endophthalmitis following intravitreal injection: antisepsis and antibiotics. Am J Ophthalmol 152:717-719
44. Halachmi-Eyal O, Lang Y, Keness Y, Miron D (2009) Preoperative topical moxifloxacin 0.5 % and povidone-iodine 5.0 % versus povidone-iodine 5.0 % alone to reduce bacterial colonization in the conjunctival sac. J Cataract Refract Surg 35:2109-2114
45. Costello P, Bakri SJ, Beer PM, Singh RJ, Falk NS, Peters GB, Melendez JA (2006) Vitreous penetration of topical moxifloxacin and gatifloxacin in humans. Retina 26:191-195
46. Milder E, Vander J, Shah C, Garg S (2012) Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection. Ophthalmology 119:1420-1424
47. Stewart MW (2011) Endophthalmitis after injections of anti-vascular endothelial growth factor drugs. Retina 31:1981-1982