The toxic effect of different concentrations of povidone iodine on the rabbit's cornea

Cutaneous and Ocular Toxicology

Volumn 28, Issue 3, 2009, Pages 119-124

  Jiang, Jin ^a,b   Wu, Miaoqin ^a   Shen, Ting ^a  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Antisepsis; Cornea; Polyvinylpyrrolidone iodine; Povidone iodine; Toxicity

Indexed keywords

POVIDONE IODINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA EDEMA; CORNEA EPITHELIUM; CORNEA INJURY; DISEASE SEVERITY; DRUG INSTILLATION; DRUG SAFETY; EXPERIMENTAL RABBIT; NONHUMAN;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CELL COUNT; CONJUNCTIVA; CORNEA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, CORNEAL; EPITHELIUM, CORNEAL; OPHTHALMIC SOLUTIONS; OPHTHALMOLOGIC SURGICAL PROCEDURES; POVIDONE-IODINE; PREOPERATIVE CARE; RABBITS; TOXICITY TESTS;

ORYCTOLAGUS CUNICULUS;

EID: 70350680971     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.1080/15569520903080511     Document Type: Article

References (21)

1. Aaberg TM, Flynn HW, Schiffman J, Newton J. Nosocomial acuteonset postoperative endophthalmitis survey. Ophthalmology 1998; 105:1004-1010.
2. Powe NR, Shein OD, Gieser SC, Tielsch JM, Luthra R, Javitt J, Steinberq EP. Synthesis of the literature on visual acuity and complications following cataract extraction with intraocular lens implantation. Arch Ophthalmol 1994; 112:239-252.
3. Ciulla TA, Starr MB, Masket S. Bacterial endophthalmitis prophylaxis for cataract surgery. An evidence-based update. Ophthalmology 2002; 109:13-24.
4. Zamora JL. Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions. Am J Surg 1986; 151:400-406.
5. Benevento WJ, Murray P, Reed CA, Pepose JS. The sensitivity of Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex type II to disinfection with povidone-iodine. Am J Ophthalmol 1990; 109:329-333.
6. Apt L, Isenberg SJ, Yoshimori R. Antimicrobial preparation of the eye for surgery. J Hosp Infect 1985; 6:163-172.
7. Apt L, Isenberg SJ, Yoshimori R, Paez JH. Chemical preparation of the eye in ophthalmic surgery. III. Effect of povidone-iodine on the conjunctiva. Arch Ophthalmol 1984; 102:728-729.
8. MacRae SM, Brown B, Edelhauser HF. The corneal toxicity of presurgical skin antiseptics. Am J Ophthalmol 1984; 97:221-232.
9. Klie F, Blge-Rasmussen I, Jensen OL. The effect of polyvinylpyrrolidone- iodine as a disinfectant in eye surgery. Acta Ophthalmol 1986; 64:67-71.
10. Roberts SM, Severin GA, Lavach JD. Antibacterial activity of dilute povidone-iodine solutions used for ocular surface disinfection in dogs. Am J Vet Res 1986; 47:1207-1210.
11. Caldwell DR, Kastl PR, Cook J, Simon J. Povidone-iodine: Its effi- cacy as a preoperative conjunctival and periocular preparation. Ann Ophthalmol 1984; 16:577-580.
12. Isenberg SJ, Apt L, Yoshimori R, Khward S. Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidoneiodine on the conjunctiva with prophylactic antibiotic. Arch Ophthalmol 1985; 103:1340-1346.
13. Wille H. Assessment of possible toxic effects of polyvinylpyrrolidoneiodine upon the human eye in conjunction with cataract extraction. An endothelial specular microscope study. Acta Ophthalmol 1982; 60:955-960.
14. Alp BN, Elibol O, Sargon MF, Aslan OS, Yanyali A, Karabas L, Talu H, Caglar Y. The effect of povidone iodine on the corneal endothelium. Cornea 2000; 19:546-550.
15. Lacey RW, Catto A. Action of povidone-iodine against methicillin- sensitive and resistant cultures of Staphylococcus aureus. Postgrad Med J 1993; 69(suppl 3):S78-S83.
16. Apt L, Isenberg SJ, Yoshimori R. The effect of povidone-iodine solution applied at the conclusion of ophthalmic surgery. Am J Ophthalmol 1995; 119: 701-705.
17. Isenberg SJ, Apt L, Yoshimori R. Efficacy of topical povidoneiodine during the first week after ophthalmic surgery. Am J Ophthalmol 1997; 124:31-35.
18. Isenberg SJ. The ocular application of povidone-iodine. Community Eye Health 2003; 16(46):30-31.
19. Panda A, Venkateswarlu K, Angra SK, Mohan M. Changes in the corneal endothelial cell count as a function of age. Indian J Ophthalmol 1985; 33:221-223.
20. Grimes SR, Hollsten D, Nauschuetz WF, Whiddon RG, Trevino SB. Effect of povidone-iodine irrigation on the preoperative chemical preparation of the eye. Mil Med 1992; 157:111-113.
21. Naor J, Savion N, Blumenthal M, Assia EI. Corneal endothelial cytotoxicity of diluted povidone-iodine. J Cataract Refract Surg 2001; 27:941-947.