Magnetic iron oxide nanoparticles for multimodal imaging and therapy of cancer

International Journal of Molecular Sciences

Volumn 14, Issue 8, 2013, Pages 15910-15930

  Thomas, Reju ^a   Park, In Kyu ^b   Jeong, Yong Yeon ^a  

^a Chonnam National University Research Institute of Medical Sciences   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

CT; MRI; Multifunctional; Multimodal; PET; SPECT; Spion; Theranostics

Indexed keywords

DEXTRAN COATED CROSS LINKED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE GLUTAMYLPROLYLPROLYLTHREONINE CONJUGATE; DOXORUBICIN; GADOLINIUM; GOLD IRON OXIDE NANOPARTICLE; GOLD NANOPARTICLE; INDIUM MESOTHELIN MONOCLONAL ANTIBODY SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE IN 111; MANGANESE DOPED MAGNETISM ENGINEERED IRON OXIDE NANOPARTICLE; NANOCARRIER; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; PACLITAXEL; SMALL INTERFERING RNA; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TECHNETIUM SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE TC 99M; THERMALLY CROSS LINKED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANTIBODY LABELING; CANCER DIAGNOSIS; CANCER THERAPY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HYPERTHERMIC THERAPY; IMAGE ANALYSIS; LUNG CANCER; LUNG CARCINOMA; MAGNETIC HYPERTHERMIA; MEDICAL RESEARCH; NANOIMAGING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL INSTRUMENTATION; PHYSICAL CHEMISTRY; POSITRON EMISSION TOMOGRAPHY; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CONTRAST MEDIA; EARLY DETECTION OF CANCER; FERRIC COMPOUNDS; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MICE; MULTIMODAL IMAGING; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84881159307     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140815910     Document Type: Review

References (70)

1. Na, H.B.; Song, I.C.; Hyeon, T. Inorganic nanoparticles for mri contrast agents. Adv. Mater. 2009, 21, 2133-2148.
2. Willmann, J.K.; van Bruggen, N.; Dinkelborg, L.M.; Gambhir, S.S. Molecular imaging in drug development. Nat. Rev. Drug Discov. 2008, 7, 591-607.
3. Kirui, D.K.; Khalidov, I.; Wang, Y.; Batt, C.A. Targeted near-ir hybrid magnetic nanoparticles for in vivo cancer therapy and imaging. Nanomed. Nanotechnol. Biol. Med. 2012, 9, 702-711.
4. Misri, R.; Meier, D.; Yung, A.C.; Kozlowski, P.; Hafeli, U.O. Development and evaluation of a dual-modality (mri/spect) molecular imaging bioprobe. Nanomed. Nanotechnol. Biol. Med. 2012, 8, 1007-1016.
5. Torres Martin de Rosales, R.; Tavare, R.; Glaria, A.; Varma, G.; Protti, A.; Blower, P.J. ((9)(9)m)tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjugate Chem. 2011, 22, 455-465.
6. Jennings, L.E.; Long, N.J. 'Two is better than one'-Probes for dual-modality molecular imaging. Chem. Commun. (Camb.) 2009, 3511-3524.
7. Heidt, T.; Nahrendorf, M. Multimodal iron oxide nanoparticles for hybrid biomedical imaging. NMR Biomed. 2012, 26, 756-765.
8. Yoo, D.; Lee, J.-H.; Shin, T.-H.; Cheon, J. Theranostic magnetic nanoparticles. Acc. Chem. Res. 2011, 44, 863-874.
9. Rosen, J.E.; Chan, L.; Shieh, D.B.; Gu, F.X. Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomed. Nanotechnol. Biol. Med. 2012, 8, 275-290.
10. Gu, F.X.; Karnik, R.; Wang, A.Z.; Alexis, F.; Levy-Nissenbaum, E.; Hong, S.; Langer, R.S.; Farokhzad, O.C. Targeted nanoparticles for cancer therapy. Nano Today 2007, 2, 14-21.
11. Yu, M.K.; Park, J.; Jon, S. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics 2012, 2, 3-44.
12. Nurunnabi, M.; Khatun, Z.; Moon, W.C.; Lee, G.; Lee, Y.K. Heparin based nanoparticles for cancer targeting and noninvasive imaging. Quant. Imaging Med. Surg. 2012, 2, 219-226.
13. Cai, W.; Chen, X. Nanoplatforms for targeted molecular imaging in living subjects. Small 2007, 3, 1840-1854.
14. Yoo, M.K.; Kim, I.Y.; Kim, E.M.; Jeong, H.J.; Lee, C.M.; Jeong, Y.Y.; Akaike, T.; Cho, C.S. Superparamagnetic iron oxide nanoparticles coated with galactose-carrying polymer for hepatocyte targeting. J. Biomed. Biotechnol. 2007, 2007, 94740.
15. Thorek, D.L.; Chen, A.K.; Czupryna, J.; Tsourkas, A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann. Biomed. Eng. 2006, 34, 23-38.
16. Jun, Y.W.; Lee, J.H.; Cheon, J. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew. Chem. Int. Ed. Engl. 2008, 47, 5122-5135.
17. Lee, G.Y.; Qian, W.P.; Wang, L.; Wang, Y.A.; Staley, C.A.; Satpathy, M.; Nie, S.; Mao, H.; Yang, L. Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and mri of pancreatic cancer. ACS Nano 2013, 7, 2078-2089.
18. Lamanna, G.; Kueny-Stotz, M.; Mamlouk-Chaouachi, H.; Ghobril, C.; Basly, B.; Bertin, A.; Miladi, I.; Billotey, C.; Pourroy, G.; Begin-Colin, S.; et al. Dendronized iron oxide nanoparticles for multimodal imaging. Biomaterials 2011, 32, 8562-8573.
19. Lee, D.E.; Koo, H.; Sun, I.C.; Ryu, J.H.; Kim, K.; Kwon, I.C. Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem. Soc. Rev. 2012, 41, 2656-2672.
20. Wang, Y.-X.; Hussain, S.; Krestin, G. Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in mr imaging. Eur. Radiol. 2001, 11, 2319-2331.
21. Liu, G.; Gao, J.; Ai, H.; Chen, X. Applications and potential toxicity of magnetic iron oxide nanoparticles. Small 2013, 9, 1533-1545.
22. Zeng, L.; Ren, W.; Zheng, J.; Cui, P.; Wu, A. Ultrasmall water-soluble metal-iron oxide nanoparticles as t1-weighted contrast agents for magnetic resonance imaging. Phys. Chem. Chem. Phys. 2012, 14, 2631-2636.
23. Kumar, K.; Nightingale, A.M.; Krishnadasan, S.H.; Kamaly, N.; Wylenzinska-Arridge, M.; Zeissler, K.; Branford, W.R.; Ware, E.; deMello, A.J.; deMello, J.C. Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor. J. Mater. Chem. 2012, 22, 4704.
24. Osborne, E.A.; Atkins, T.M.; Gilbert, D.A.; Kauzlarich, S.M.; Liu, K.; Louie, A.Y. Rapid microwave-assisted synthesis of dextran-coated iron oxide nanoparticles for magnetic resonance imaging. Nanotechnology 2012, 23, 215602.
25. Belaid, S.; Laurent, S.; Vermeech, M.; Elst, L.V.; Perez-Morga, D.; Muller, R.N. A new approach to follow the formation of iron oxide nanoparticles synthesized by thermal decomposition. Nanotechnology 2013, 24, 055705.
26. Ling, D.; Hyeon, T. Chemical design of biocompatible iron oxide nanoparticles for medical applications. Small 2013, 9, 1450-1466.
27. Gupta, A.K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26, 3995-4021.
28. O'Farrell, A.; Shnyder, S.; Marston, G.; Coletta, P.; Gill, J. Non-invasive molecular imaging for preclinical cancer therapeutic development. Br. J. Pharmacol. 2013, 169, 719-735.
29. Hendee WR, M.C. Magnetic resonance imaging. Part1-physical principles. West. J. Med. 1984, 141, 491-500.
30. Ntziachristos, V.; Bremer, C.; Weissleder, R. Fluorescence imaging with near-infrared light: New technological advances that enable in vivo molecular imaging. Eur. Radiol. 2003, 13, 195-208.
31. Pierce, M.C.; Javier, D.J.; Richards-Kortum, R. Optical contrast agents and imaging systems for detection and diagnosis of cancer. Int. J. Cancer 2008, 123, 1979-1990.
32. Shah, K.; Weissleder, R. Molecular optical imaging: Applications leading to the development of present day therapeutics. Neurotherapeutics 2005, 2, 215-225.
33. Wang, H. Agents that induce pseudo-allergic reaction. Drug Discov. Ther. 2011, 5, 211-219.
34. Goldman, L.W. Principles of ct and ct technology. J. Nuclear Med. Technol. 2007, 35, 115-128; quiz 129-130.
35. Hasebroock, K.M.; Serkova, N.J. Toxicity of mri and ct contrast agents. Expert Opin. Drug Metabol. Toxicol. 2009, 5, 403-416.
36. Giljohann, D.A.; Seferos, D.S.; Daniel, W.L.; Massich, M.D.; Patel, P.C.; Mirkin, C.A. Gold nanoparticles for biology and medicine. Angew. Chem. Int. Ed. Engl. 2010, 49, 3280-3294.
37. Cassidy, P.J.; Radda, G.K. Molecular imaging perspectives. J. R. Soc. Interface R. Soc. 2005, 2, 133-144.
38. Nahrendorf, M.; Zhang, H.; Hembrador, S.; Panizzi, P.; Sosnovik, D.E.; Aikawa, E.; Libby, P.; Swirski, F.K.; Weissleder, R. Nanoparticle pet-ct imaging of macrophages in inflammatory atherosclerosis. Circulation 2008, 117, 379-387.
39. Sosnovik, D.E.; Nahrendorf, M.; Weissleder, R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation 2007, 115, 2076-2086.
40. Park, J.H.; von Maltzahn, G.; Ruoslahti, E.; Bhatia, S.N.; Sailor, M.J. Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angew. Chem. Int. Ed. Engl. 2008, 47, 7284-7288.
41. Josephson, L.; Kircher, M.F.; Mahmood, U.; Tang, Y.; Weissleder, R. Near-infrared fluorescent nanoparticles as combined mr/optical imaging probes. Bioconjugate Chem. 2002, 13, 554-560.
42. Cha, E.J.; Jang, E.S.; Sun, I.C.; Lee, I.J.; Ko, J.H.; Kim, Y.I.; Kwon, I.C.; Kim, K.; Ahn, C.H. Development of mri/nirf 'activatable' multimodal imaging probe based on iron oxide nanoparticles. J. Control. Release 2011, 155, 152-158.
43. He, X.; Gao, J.; Gambhir, S.S.; Cheng, Z. Near-infrared fluorescent nanoprobes for cancer molecular imaging: Status and challenges. Trends Mol. Med. 2010, 16, 574-583.
44. Lee, H.; Yu, M.K.; Park, S.; Moon, S.; Min, J.J.; Jeong, Y.Y.; Kang, H.-W.; Jon, S. Thermally cross-linked superparamagnetic iron oxide nanoparticles: Synthesis and application as a dual imaging probe for cancer in vivo. J. Am. Chem. Soc. 2007, 129, 12739-12745.
45. Medarova, Z.; Pham, W.; Kim, Y.; Dai, G.; Moore, A. In vivo imaging of tumor response to therapy using a dual-modality imaging strategy. Int. J. Cancer 2006, 118, 2796-2802.
46. Moore, A.; Medarova, Z.; Potthast, A.; Dai, G. In vivo targeting of underglycosylated muc-1 tumor antigen using a multimodal imaging probe. Cancer Res. 2004, 64, 1821-1827.
47. Wang, Y.X. Superparamagnetic iron oxide based mri contrast agents: Current status of clinical application. Quant. Imag. Med. Surg. 2011, 1, 35-40.
48. Kim, D.-K.; Kim, J.-W.; Jeong, Y.-Y.; Jon, S.-Y. Antibiofouling polymer coated gold@iron oxide nanoparticle (gion) as a dual contrast agent for ct and mri. Bull. Korean Chem. Soc. 2009, 30, 1855-1857.
49. Kim, D.; Yu, M.K.; Lee, T.S.; Park, J.J.; Jeong, Y.Y.; Jon, S. Amphiphilic polymer-coated hybrid nanoparticles as ct/mri dual contrast agents. Nanotechnology 2011, 22, 155101.
50. Cherry, S.R. Multimodality imaging: Beyond pet/ct and spect/ct. Semin. Nuclear Med. 2009, 39, 348-353.
51. Yang, X.; Hong, H.; Grailer, J.J.; Rowland, I.J.; Javadi, A.; Hurley, S.A.; Xiao, Y.; Yang, Y.; Zhang, Y.; Nickles, R.J.; et al. Crgd-functionalized, dox-conjugated, and (6)(4)cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and pet/mr imaging. Biomaterials 2011, 32, 4151-4160.
52. Lee, H.Y.; Li, Z.; Chen, K.; Hsu, A.R.; Xu, C.; Xie, J.; Sun, S.; Chen, X. Pet/mri dual-modality tumor imaging using arginine-glycine-aspartic (rgd)-conjugated radiolabeled iron oxide nanoparticles. J. Nuclear Med. 2008, 49, 1371-1379.
53. Torres Martin de Rosales, R.; Tavare, R.; Paul, R.L.; Jauregui-Osoro, M.; Protti, A.; Glaria, A.; Varma, G.; Szanda, I.; Blower, P.J. Synthesis of 64cu(ii)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: In vivo evaluation as dual-modality pet-mri agent. Angew. Chem. Int. Ed. Engl. 2011, 50, 5509-5513.
54. Rimkus, G.; Gruttner, C.; Bremer-Streck, S.; Herrmann, K.H.; Krumbein, I.; Reichenbach, J.R.; Foerster, M.; Kaiser, W.A.; Hilger, I. Mvcam-1 specific iron oxide nanoparticles based probes for multimodal imaging purposes. Biomed. Technik. Biomed. Eng. 2012, doi:10.1515/bmt-2012-4100
55. Madru, R.; Kjellman, P.; Olsson, F.; Wingardh, K.; Ingvar, C.; Stahlberg, F.; Olsrud, J.; Latt, J.; Fredriksson, S.; Knutsson, L.; et al. 99mtc-labeled superparamagnetic iron oxide nanoparticles for multimodality spect/mri of sentinel lymph nodes. J. Nuclear Med. 2012, 53, 459-463.
56. Santra, S.; Kaittanis, C.; Grimm, J.; Perez, J.M. Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging. Small 2009, 5, 1862-1868.
57. Drake, P.; Cho, H.-J.; Shih, P.-S.; Kao, C.-H.; Lee, K.-F.; Kuo, C.-H.; Lin, X.-Z.; Lin, Y.-J. Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia. J. Mater. Chem. 2007, 17, 4914.
58. Silva, A.C.; Oliveira, T.R.; Mamani, J.B.; Malheiros, S.M.; Malavolta, L.; Pavon, L.F.; Sibov, T.T.; Amaro, E., Jr.; Tannus, A.; Vidoto, E.L.; et al. Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment. Int. J. Nanomed. 2011, 6, 591-603.
59. Zhao, Q.; Wang, L.; Cheng, R.; Mao, L.; Arnold, R.D.; Howerth, E.W.; Chen, Z.G.; Platt, S. Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models. Theranostics 2012, 2, 113-121.
60. Laurent, S.; Dutz, S.; Hafeli, U.O.; Mahmoudi, M. Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles. Adv. Colloid Interface Sci. 2011, 166, 8-23.
61. Lee, J.H.; Lee, K.; Moon, S.H.; Lee, Y.; Park, T.G.; Cheon, J. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and sirna delivery. Angew. Chem. Int. Ed. Engl. 2009, 48, 4174-4179.
62. Quan, Q.; Xie, J.; Gao, H.; Yang, M.; Zhang, F.; Liu, G.; Lin, X.; Wang, A.; Eden, H.S.; Lee, S.; et al. Hsa coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy. Mol. Pharm. 2011, 8, 1669-1676.
63. Yu, M.K.; Jeong, Y.Y.; Park, J.; Park, S.; Kim, J.W.; Min, J.J.; Kim, K.; Jon, S. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew. Chem. Int. Ed. Engl. 2008, 47, 5362-5365.
64. Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J.; Gao, J.; Li, X.; Chen, X. Pet/nirf/mri triple functional iron oxide nanoparticles. Biomaterials 2010, 31, 3016-3022.
65. Dey, S.; Maiti, T.K. Superparamagnetic nanoparticles and rnai-mediated gene silencing: Evolving class of cancer diagnostics and therapeutics. J. Nanomater. 2012, 2012, 1-15.
66. Lim, J.; Clements, M.A.; Dobson, J. Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis. PLoS One 2012, 7, doi:10.1371/journal.pone.0051350
67. Dobson, J. Gene therapy progress and prospects: Magnetic nanoparticle-based gene delivery. Gene Ther. 2006, 13, 283-287.
68. Waerzeggers, Y.; Monfared, P.; Viel, T.; Winkeler, A.; Voges, J.; Jacobs, A.H. Methods to monitor gene therapy with molecular imaging. Methods 2009, 48, 146-160.
69. Chen, Y.; Wang, W.; Lian, G.; Qian, C.; Wang, L.; Zeng, L.; Liao, C.; Liang, B.; Huang, B.; Huang, K.; et al. Development of an mri-visible nonviral vector for sirna delivery targeting gastric cancer. Int. J. Nanomed. 2012, 7, 359-368.
70. Hoskins, C.; Min, Y.; Gueorguieva, M.; McDougall, C.; Volovick, A.; Prentice, P.; Wang, Z.; Melzer, A.; Cuschieri, A.; Wang, L. Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application. J. Nanobiotechnol. 2012, 10, 27.