Whole body irradiation induces cutaneous dendritic cells depletion via NF-κB activation

Cellular Physiology and Biochemistry

Volumn 32, Issue 1, 2013, Pages 200-209

  Yang, Yanyong ^a   Cui, Jianguo ^a   Gao, Fu ^a   Li, Bailong ^a   Liu, Cong ^a   Zhang, Pei ^a   Huang, Yijuan ^a   Liu, Wen ^a   Liu, Hu ^a   Cai, Jianming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dendritic cells; Migration; NF B; Whole body irradiation

Indexed keywords

CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; FLUORESCEIN ISOTHIOCYANATE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; UPREGULATION; WHOLE BODY RADIATION; ANIMAL CELL; CELL COUNT; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; LYMPH NODE; REAL TIME POLYMERASE CHAIN REACTION; SKIN CELL; WESTERN BLOTTING;

ANIMALS; CELL MOVEMENT; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; FEMALE; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PROLINE; SKIN; THIOCARBAMATES; TOLL-LIKE RECEPTOR 4; UP-REGULATION; WHOLE-BODY IRRADIATION;

EID: 84881121602     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000350136     Document Type: Article

References (31)

1. Ryan JL: Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol 2012;132:985-993.
2. Cummings RJ, Gerber SA, Judge JL, Ryan JL, Pentland AP, Lord EM: Exposure to Ionizing Radiation Induces the Migration of Cutaneous Dendritic Cells by a CCR7-Dependent Mechanism. J Immunol 2012;189:4247-4257.
3. Bennett CL, Van Rijn E, Jung S, Inaba K, Steinman R-M, Kapsenberg ML, Clausen BE: Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 2005;169:569-576.
4. Randolph GJ: Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators. Semin Immunol 2001;13:267-274.
5. Cole S: Long-term effects of local ionizing radiation treatment on Langerhans cells in mouse footpad epidermis. J Invest Dermatol 1986;87:608-612.
6. Cummings RJ, Mitra S, Foster TH, Lord EM: Migration of skin dendritic cells in response to ionizing radiation exposure. Radiat Res 2009;171:687-697.
7. Liu C, Lin J, Zhao L, Yang Y, Gao F, Li B, Cui J, Cai J: Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis. Int J Biol Sci 2011;7:168-179.
8. Robbiani DF, Finch RA, Jager D, Muller WA, Sartorelli AC, Randolph GJ: The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 2000;103:757-768.
9. Ratzinger G, Stoitzner P, Ebner S, Lutz MB, Layton GT, Rainer C, Senior RM, Shipley JM, Fritsch P, Schuler G, Romani N: Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skin. J Immunol 2002;168:4361-4371.
10. Haridas S, Bowers M, Tusano J, Mehojah J, Kirkpatrick M, Eburnham DK: The impact of Meth A fibrosarcoma derived EMAP II on dendritic cell migration. Cytokine 2008;44:304-309.
11. Lin J, Liu C, Gao F, Mitchel R-E, Zhao L, Yang Y, Lei J, Cai J: MiR-200c enhances radiosensitivity of human breast cancer cells. J Cell Biochem 2013;114:606-615.
12. Hatfield P, Merrick A, Harrington K, Vile R, Bateman A, Selby P, Melcher A: Radiation-induced cell death and dendritic cells: potential for cancer immunotherapy? Clin Oncol (R Coll Radiol) 2005;17:1-11.
13. Hegde S, Pahne J, Smola-Hess S: Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NF-kappaB binding activity and CCR7 expression. FASEB J 2004;18:1439-441.
14. Sasaki H, Zhu L, Fukuda S, Maulik N: Inhibition of NF kappa B activation by pyrrolidine dithiocarbamate prevents in vivo hypoxia/reoxygenation-mediated myocardial angiogenesis. Int J Tissue React 2000;22:93-100.
15. Alaniz L, Rizzo M, Piccioni F, Aquino JB, Malvivini M, Atorrasagasti C, Bayo J, Echeverria I, Sarobe P, Mazzolini G: Low molecular weight hyaluronan preconditioning of tumor-pulsed dendritic cells increases their migratory ability and induces immunity against murine colorectal carcinoma. Cancer Immunol Immunother 2011;60:1383-1395.
16. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998;392:245-252.
17. Rao V, Saunes M, Jorstad S, Moen T: In vitro experiments demonstrate that monocytes and dendritic cells are rendered apoptotic by extracorporeal photochemotherapy, but exhibit unaffected surviving and maturing capacity after 30 Gy gamma irradiation. Scand J Immunol 2008;68:645-651.
18. Martin-Fontecha A, Lanzavecchia A, Sallusto F: Dendritic cell migration to peripheral lymph nodes. Handb Exp Pharmacol 2009;188:31-49.
19. Colvin B-L, Matta BM, Thomson AW: Dendritic cells and chemokine-directed migration in transplantation: where are we headed? Clin Lab Med 2008;28:375-384.
20. Alvarez D, Vollmann EH, von Andrian UH: Mechanisms and consequences of dendritic cell migration. Immunity 2008;29:325-42.
21. Ohl L, Mohaupt M, Czeloth N, Hintzen G, Kiafard Z, Zwirner J, Blankenstein T, Henning G, Forster R: CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004;21:279-288.
22. Johnson LA, Jackson DG: Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration. Int Immunol 2010;22:839-849.
23. Murphy, PM: Double duty for CCL21 in dendritic cell trafficking. Immunity 2010;32:590-592.
24. Hansson M, Lundgren A, Elgbratt K, Quiding-Jarbrink M, Svennerholm A-M, Johansson E-L: Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3beta) after exposure to Helicobacter pylori. Microbes Infect 2006;8:841-850.
25. Jang M-H, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, Guo Z, Umemoto E, Ebisuno Y, Yang B-G, Seoh JY, Lipp M, Kiyono H, Miyasaka M: CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 2006;176:803-810.
26. Luckey TD: Radiation hormesis: the good, the bad, and the ugly. Dose Response 2006;4:169-190.
27. Pahl HL: Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999;18:6853-6866.
28. Stoitzner P, Zanella M, Ortner U, Lukas M, Tagwerker A, Janke K, Lutz MB, Schuler G, Echtenacher B, Ryffel B, Koch F, Romani N: Migration of langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-alpha and IL-1beta. J Leukoc Biol 1999;66:462-470.
29. Muller JR, Siebenlist U: Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. J Biol Chem 2003;278:2006-2012.
30. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X: Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood 2004;103:413-421.
31. Liu SF, Ye X, Malik AB: Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. Circulation 1999;100:1330-1337.