A mycobacteriophage-derived trehalose-6,6=-dimycolatebinding peptide containing both antimycobacterial and anti-inflammatory abilities

FASEB Journal

Volumn 27, Issue 8, 2013, Pages 3067-3077

  Wei, Lin ^a,b   Wu, Jing ^a,c   Liu, Han ^a,c   Yang, Hailong ^a   Rong, Mingqiang ^a   Li, Dongsheng ^a   Zhang, Pinghu ^d,e   Han, Junyou ^e   Lai, Ren ^a,b  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d CHINA PHARMACEUTICAL UNIVERSITY   (China)

^e JILIN UNIVERSITY   (China)

Author keywords

Cord factor; Cytokine; Immunoregulative effects; Mouse model; Mycobacterium tuberculosis

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIMYCOBACTERIAL AGENT; CORD FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PK 34; PROTEIN KINASE B; RIFAMPICIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CYTOKINE; IMMUNOLOGICAL ADJUVANT; PEPTIDE; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING AFFINITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG BINDING; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; GRANULOMA; GRANULOMATOUS INFLAMMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IMMUNOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; ISOELECTRIC POINT; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIOPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; LUNG; MACROPHAGE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PATHOLOGY; TUBERCULOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL LINE; CORD FACTORS; CYTOKINES; FEMALE; LUNG; MACROPHAGES; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOBACTERIOPHAGES; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RIFAMPIN; TUBERCULOSIS;

EID: 84881120554     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-227454     Document Type: Article

References (33)

1. Haydel, S. E. (2010) Extensively drug-resistant tuberculosis: a sign of the times and an impetus for antimicrobial discovery. Pharmaceuticals (Basel) 3, 2268-2290
2. Bloom, B. R., and Murray, C. J. (1992) Tuberculosis: commentary on a reemergent killer. Science 257, 1055-1064
3. Centers for Disease Control Prevention (2006) Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004. MMWR Recomm. Rep. 55, 301-305
4. Raviglione, M. C., and Smith, I. (2007) XDR tuberculosisimplications for global public health. N. Engl. J. Med. 356, 656-659
5. Liu, J., Dehbi, M., Moeck, G., Arhin, F., Bauda, P., Bergeron, D., Callejo, M., Ferretti, V., Ha, N., Kwan, T., McCarty, J., Srikumar, R., Williams, D., Wu, J. J., Gros, P., Pelletier, J., and DuBow, M. (2004) Antimicrobial drug discovery through bacteriophage genomics. Nat. Biotechnol. 22, 185-191
6. Nechaev, S., and Severinov, K. (1999) Inhibition of Escherichia coli RNA polymerase by bacteriophage T7 gene 2 protein. J. Mol. Biol. 289, 815-826
7. Orsini, G., Ouhammouch, M., Le Caer, J. P., and Brody, E. N. (1993) The asiA gene of bacteriophage T4 codes for the anti-sigma 70 protein. J. Bacteriol. 175, 85-93
8. Mallory, J. B., Alfano, C., and McMacken, R. (1990) Host virus interactions in the initiation of bacteriophage lambda DNA replication. Recruitment of Escherichia coli DnaB helicase by lambda P replication protein. J. Biol. Chem. 265, 13297-14307
9. Odegrip, R., Schoen, S., Haggard-Ljungquist, E., Park, K., and Chattoraj, D. K. (2000) The interaction of bacteriophage P2 B protein with Escherichia coli DnaB helicase. J. Virol. 74, 4057-4063
10. Yoong, P., Schuch, R., Nelson, D., and Fischetti, V. A. (2006) PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis. J. Bacteriol. 188, 2711-2714
11. Schuch, R., Nelson, D., and Fischetti, V. A. (2002) A bacteriolytic agent that detects and kills Bacillus anthracis. Nature 418, 884-889
12. Loeffler, J. M., Nelson, D., and Fischetti, V. A. (2001) Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase. Science 294, 2170-2172
13. Hatfull, G. F. (2010) Mycobacteriophages: genes and genomes. Annu. Rev. Microbiol. 64, 331-356
14. Figueiredo, R., Moiteiro, C., Medeiros, M. A., da Silva, P. A., Ramos, D., Spies, F., Ribeiro, M. O., Lourenço, M. C., Júnior, I. N., Gaspar, M. M., Cruz, M. E., Curto, M. J., Franzblau, S. G., Orozco, H., Aguilar, D., Hernandez-Pando, R., and Costa, M. C. (2009) Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H(37)Rv, MDR and NRP Mycobacterium tuberculosis. Bioorg. Med. Chem. 17, 503-511
15. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63
16. Welsh, K. J., Hwang, S. A., Hunter, R. L., Kruzel, M. L., and Actor, J. K. (2010) Lactoferrin modulation of mycobacterial cord factor trehalose 6-6=-dimycolate induced granulomatous response. Transl. Res. 156, 207-215
17. McNerney, R., Traoré H. (2005) Mycobacteriophage and their application to disease control. J. Appl. Microbiol. 99, 223-233
18. Schoolnik, G. K., Summers, W. C., and Watson, J. D. (2004) Phage offer a real alternative. Nat. Biotechnol. 22, 505-506
19. Ma, Y., Liu, C., Liu, X., Wu, J., Yang, H., Wang, Y., Li, J., Yu, H., and Lai, R. (2010) Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics 95, 66-71
20. Li, J., Xu, X., Xu, C., Zhou, W., Zhang, K., Yu, H., Zhang, Y., Zheng, Y., Rees, H. H., Lai, R., Yang, D., and Wu, J. (2007) Anti-infection peptidomics of amphibian skin. Mol. Cell. Proteomics 6, 882-894
21. Matsunaga, I., and Moody, D. B. (2009) Mincle is a long sought receptor for mycobacterial cord factor. J. Exp. Med. 206, 2865-2868
22. Hunter, R. L., Olsen, M. R., Jagannath, C., and Actor, J. K. (2006) Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease. Ann. Clin. Lab. Sci. 36, 371-386
23. Bekierkunst, A., Levij, I. S., Yarkoni, E., Vilkas, E., Adam, A., and Lederer, E. (1969) Granuloma formation induced in mice by chemically defined mycobacterial fractions. J. Bacteriol. 100, 95-102
24. Geisel, R. E., Sakamoto, K., Russell, D. G., and Rhoades, E. R. (2005) In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates. J. Immunol. 174, 5007-5015
25. Paige, C., and Bishai, W. R. (2010) Penitentiary or penthouse condo: the tuberculous granuloma from the microbe's point of view. Cell. Microbiol. 12, 301-309
26. Co, D. O., Hogan, L. H., Kim, S. I., and Sandor, M. (2004) Mycobacterial granulomas: keys to a long-lasting hostpathogen relationship. Clin. Immunol. 113, 130-136
27. Chan, J., and Flynn, J. (2004) The immunological aspects of latency in tuberculosis. Clin. Immunol. 110, 2-12
28. Cooper, A. M., and Khader, S. A. (2008) The role of cytokines in the initiation, expansion, and control of cellular immuniy to tuberculosis. Immunol. Rev. 226, 191-204
29. Lee W. B., Kang J. S., Yan J. J., Lee M. S., Jeon B. Y., Cho, S. N., and Kim, Y. J. (2012) Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the mincle pathway. PLoS Pathog. 8, e1002614
30. Chang, L., and Karin, M. (2001) Mammalian MAP kinase signaling cascades. Nature 410, 37
31. Ojaniemi, M., Glumoff, V., Harju, K., Liljeroos, M., Vuori, K., and Hallman, M. (2003) Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur. J. Immunol. 33, 597-605
32. Kim, J. H., Na, H. J., Kim, C. K., Kim, J. Y., Ha, K. S., Lee, H., Chung, H. T., Kwon, H. J., Kwon, Y. G., and Kim, Y. M. (2008) The non-provitamin A carotenoid, lutein, inhibits NF-B-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-B-inducing kinase pathways: role of H2O2 in NF-B activation. Free Radic. Biol. Med. 45, 885-896
33. Leal, I. S., Smedegard, B., Andersen, P., and Appelberg, R. (1999) Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine. Infect. Immun. 67, 5747-5754