DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues

Regulatory Peptides

Volumn 186, Issue , 2013, Pages 26-35

  Harstad, Eric B ^a   Rosenblum, Jonathan S ^b   Gorrell, Mark D ^c   Achanzar, William E ^a   Minimo, Lauro ^b,d   Wu, Jiangyue ^b   Rosini Marthaler, Laura ^a   Gullo, Russell ^a   Ordway, Nicole D ^a   Kirby, Mark S ^a   Chadwick, Kristina D ^a   Cosma, Gregory N ^a,e   Moyer, Carolyn F ^a,f  

^a BRISTOL MYERS SQUIBB   (United States)

^b ACTIVX BIOSCIENCES INC   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d St Francis De Sales Center for Priestly Formation   (United States)

^e GENENTECH INC   (United States)

^f AMGEN INC   (United States)

Author keywords

Dipeptidyl peptidase; DPP4; DPP8; DPP9; Monkey; Rat

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE 9; DIPEPTIDYL PEPTIDASE IV; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; EPITHELIUM CELL; FEMALE; GENE FUNCTION; GENE IDENTIFICATION; IMMUNOHISTOCHEMISTRY; LYMPHOID CELL; MACACA FASCICULARIS; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; SPECIES DIFFERENCE; TISSUE CHARACTERIZATION;

CDNA; COMPLEMENTARY DNA; DIPEPTIDYL PEPTIDASE; DPP; DPP4; DPP8; DPP9; IGG; IMMUNOGLOBULIN G; MESSENGER RNA; MICROLITER; MONKEY; MRNA; NANOGRAM; NG; PBS; PHOSPHATE BUFFERED SALINE; RAT; ΜL;

AMINO ACID SEQUENCE; ANIMALS; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; FEMALE; GENE EXPRESSION; KIDNEY; MACACA FASCICULARIS; MALE; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PANCREAS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 84881103262     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2013.07.003     Document Type: Article

References (48)

1. Gorrell M.D., Gysbers V., McCaughan G.W. CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol 2001, 54:249-264.
2. Lambeir A.-M., Durinx C., Scharpé S., De Meester I. Dipeptidyl peptidase IV from bench to bedside: an update on structural properties, functions and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 2003, 40:209-294.
3. Rosenblum J.R., Kozarich J.W. Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Curr Opin Chem Biol 2003, 7:496-504.
4. Kirby M.S., Yu D.M.T., O'Connor S., Gorrell M.D. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clin Sci 2010, 118:31-41.
5. Gorrell M.D. Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin Sci 2005, 108:277-292.
6. Mentlein R. Therapeutic assessment of glucagon-like peptide-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential antidiabetic drugs. Expert Opin Investig Drugs 2005, 14:57-64.
7. Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract 2006, 60:1454-1470.
8. Drucker D.J. The role of gut hormones in glucose homeostasis. J Clin Invest 2007, 117:24-32.
9. Yu D.M.T., Yao T.-W., Chowdhury S., Nadvi N.A., Osborne B., Church W.B., McCaughan G.W., Gorrell M.D. The dipeptidyl peptidase IV family in cancer and cell biology. FEBS J 2010, 277:1126-1144.
10. Wilson C.H., Indarto D., Doucet A., Pogson L.D., Pitman M.R., Menz R.I., McNicholas K., Overall C.M., Abbott C.A. Identifying natural substrates for dipeptidyl peptidase 8 (DP8) and DP9 using terminal amine isotopic labeling of substrates, TAILS, reveals in vivo roles in cellular homeostasis and energy metabolism. J Biol Chem 2013, 288(20):13936-13949.
11. Abbott C.A., Yu D.M.T., Woollatt E., Sutherland G.R., McCaughan G.W., Gorrell M.D. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur J Biochem 2000, 267:6140-6150.
12. Olson C., Wagtmann N. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. Gene 2002, 299:185-193.
13. Qi S.Y., Riviere P.J., Trojnar J., Junien J.L., Akinsanya K.O. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Biochem J 2003, 373:179-189.
14. Ajami K., Abbott C.A., McCaughan G.W., Gorrell M.D. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Biochim Biophys Acta 2004, 16791:18-28.
15. Maes M.B., Dubois V., Brandt I., Lambeir A.-M., Van der Veken P., Augustyns K., Cheng J.D., Chen X., Scharpé S., Meester I.D. Dipeptidyl peptidase 8/9-like activity in human leukocytes. J Leukoc Biol 2007, 81:1252-1257.
16. Dubois V., Ginneken C.V., De Cock H., Lambier A.-M., Van der Veken P., Augustyns K., Chen X., Scharpe S., De Meester I. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. J Histochem Cytochem 2009, 57(6):531-541.
17. Hartel S., Gossrau R., Hanski C., Reutter W. Dipeptidyl peptidase (DPP)IV in rat organs. Comparison of immunohistochemistry and activity histochemistry. Histochemistry 1988, 892:151-161.
18. McCaughan G.W., Wickson J.E., Creswick P.F., Gorrell M.D. Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence. Hepatology 1990, 11:534-544.
19. Hartel-Schenk S., Gossrau R., Reutter W. Comparative immunohistochemistry and histochemistry of dipeptidyl peptidase IV in rat organs during development. Histochem J 1990, 22:567-578.
20. Karl T., Chwalisz W.T., Wedekind D., Hedrich H.J., Hoffmann T., Jacobs R., Pabst R., von Hörsten S. Localization, transmission, spontaneous mutations, and variation of function of the dpp4 (dipeptidyl-peptidase IV; CD26) gene in rats. Regul Pept 2003, 115:81-90.
21. Bjelke J.R., Christensen J., Nielsen P.F., Branner S., Kanstrup A.B., Wagtmann N., Rasmussen H.B. Dipeptidyl peptidase 8 and 9 specificity and molecular characterization compared to dipeptidyl peptidase IV. Biochem J 2006, 396(2):391-399.
22. Ajami K., Pitman M.R., Wilson C.H., Park J., Menz R.I., Starr A.E., Cox J.H., Abbott C.A., Overall C.M., Gorrell M.D. Inflammatory protein-10, interferon-inducible T cell chemo-attractant and stromal cell-derived factors 1α and 1β are novel substrates of dipeptidyl peptidase 8. FEBS Lett 2008, 582:819-825.
23. Geiss-Friedlander R., Parmentier N., Moller U., Urlaub H., Van den Eynde B., Melchior F. The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline containing peptides. J Biol Chem 2009, 284(40):27211-27219.
24. Yu D.M.T., Ajami K., Gall M.G., Park J., Lee C.S., Evans K., McLaughlin E.A., Pitman M.R., Abbott C.A., McCaughan G.W., Gorrell M.D. The in vivo expression of dipeptidyl peptidases 8 and 9. J Histochem Cytochem 2009, 57(11):1025-1040.
25. Lankas G.R., Leiting B., Roy R.S., Eiermann G.J., Beconi M.G., Biftu T., Chan C.-C., Edmondson S., Feeney W.P., He H., Ippolito D.E., Kim D., Lyons K.A., Ok H.O., Patel R.A., Petrov A.N., Pryor K.A., Qian X., Reigle L., Woods A., Wu J.K., Zaller D., Zhang X., Zhu L., Weber A.E., Thornberry N.A. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 2005, 54:2988-2994.
26. Ansorge S., Bank U., Heimburg A., Helmuth M., Koch G., Tadje J., Lendeckel U., Wolke C., Neubert K., Faust J., Fuchs P., Reinhold D., Thielitz A., Täger M. Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med 2009, 47(3):253-261.
27. Chowdhury S., Chen Y., Yao T.-W., Ajami K., Wang X.M., Popov Y., Schuppan D., Bertolino P., McCaughan G.W., Yu D.M., Gorrell M.D. Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol 2013, 19(19):2883-2893.
28. Yu D.M.T., Wang X.M., McCaughan G.W., Gorrell M.D. Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. FEBS J 2006, 273:2447-2460.
29. Yao T.-W., Kim W.-S., Yu D.M., Sharbeen G., McCaughan G.W., Choi K.-Y., Xia P., Gorrell M.D. A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling. Mol Cancer Res 2011, 9:948-959.
30. Schade J., Stephan M., Schmiedl A., Wagner L., Niestroj A.J., Demuth H.U., Frerker N., Klemann C., Raber K.A., Pabst R., von Horsten S. Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats. J Histochem Cytochem 2008, 56(2):147-155.
31. Zhu H., Zhou Z.M., Lu L., Xu M., Wang H., Li J.M., Sha J.H. Expression of a novel dipeptidyl peptidase 8 (DPP8) transcript variant, DPP8-v3, in human testis. Asian J Androl 2005, 7:245-255.
32. Pilla E., Möller U., Sauer G., Mattiroli F., Melchior F., Geiss-Friedlander R. A novel SUMO1-specific interacting motif in Dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J Biol Chem 2012, 287:44320-44329.
33. Rosenblum J.S., Minimo L., Liu Y., et al. The case against toxicity from dpp8/9 inhibition 2007, American Diabetes Association, [Poster 519].
34. Burkey B.F., Hoffman P.K., Hassiepen U., Trappe J., Juedes M., Foley J.E. Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited. Diabetes Obes Metab 2008, 10:1057-1061.
35. Wu J.J., Tang H.K., Yeh T.K., Chen C.M., Shy H.S., Chu Y.R., Chien C.H., Tsai T.Y., Huang Y.C., Huang Y.L., Huang C.H., Tseng H.Y., Jiaang W.T., Chao Y.S., Chen X. Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol 2009, 78:203-210.
36. Patricelli M.P., Giang D.K., Stamp L.M., Burbaum J.J. Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes. Proteomics 2001, 1:1067-1071.
37. Okerberg E.S., Wu J., Zhang B., Samii B., Blackford K., Winn D.T., Shreder K.R., Burbaum J.J., Patricelli M.P. High-resolution functional proteomics by active-site peptide profiling. PNAS 2005, 102:4996-5001.
38. Feng J., Zhang Z., Wallace M.B., Stafford J.A., Kaldor S.W., Kassel D.B., Narve M., Shi L., Skene R.J., Asakawa T., Takeuchi K., Xu R., Webb D.R., Gwaltney S.L. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem 2007, 50:2297-2300.
39. Ajami K., Abbott C.A., Obradovic M., Gysbers V., Kähne T., McCaughan G.W., Gorrell M.D. Structural requirements for catalysis, expression and dimerisation in the CD26/DPIV gene family. Biochemistry 2003, 42:694-701.
40. Lee H.J., Chen Y.S., Chou C.Y., Chien C.H., Lin C.H., Chang G.G., Chen X. Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8. J Biol Chem 2006, 281:38653-38662.
41. Kähne T., Kroning H., Theil U., Ulmer A.J., Flad H.-D., Ansorge S. Alterations in structure and cellular localization of molecular forms of DPIV/CD26 during T cell activation. Cell Immunol 1996, 170:63-70.
42. Boonacker E., Van Noorden C.J. The multifunctional or moonlighting protein CD26/DPPIV. Eur J Cell Biol 2003, 82:53-73.
43. Tiruppathi C., Miyamoto Y., Ganapathy V., Roesel R.A., Whitford G.M., Leibach F.H. Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains. J Biol Chem 1990, 265(3):1476-1483.
44. Boonacker E.P., Wierenga E.A., Smits H.H., Van Noorden C.J.F. CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2cell lines as detected with living cell cytochemistry. J Histochem Cytochem 2002, 50(9):1169-1177.
45. Tinoco A.D., Tagore D.M., Saghatelian A. Expanding the Dipeptidyl Peptidase 4-Regulated Peptidome via an Optimized Peptidomics Platform. J Am Chem Soc 2010, 132:3819-3830.
46. Abbott C.A., McCaughan G.W., Levy M.T., Church W.B., Gorrell M.D. Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted beta propeller domain. Eur J Biochem 1999, 266(3):798-810.
47. Wang X.M., Yu D.M.T., McCaughan G.W., Gorrell M.D. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology 2005, 42:935-945.
48. Stiller D., Bahn H., August C. Demonstration of glomerular DPP IV activity in kidney diseases. Acta Histochem 1991, 91:105-109.