Inhibitory effect of an urotensin II receptor antagonist on proinflammatory activation induced by urotensin II in human vascular endothelial cells

Biomolecules and Therapeutics

Volumn 21, Issue 4, 2013, Pages 277-283

  Park, Sung Lyea ^a   Lee, Bo Kyung ^a   Kim, Young Ae ^a,b   Lee, Byung Ho ^c   Jung, Yi Sook ^a,b  

^a Kyung Hee University   (South Korea)

^b Ajou University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Adhesion molecules; Cytokines; Endothelial cells; Tissue factor; Urotensin II; Urotensin II receptor antagonist

Indexed keywords

2 BROMO N [4 CHLORO 3 [(1 METHYL 3 PYRROLIDINYL)OXY]PHENYL] 4,5 DIMETHOXYBENZENESULFONAMIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; THROMBOPLASTIN; UROTENSIN II; UROTENSIN RECEPTOR ANTAGONIST; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SEQUENCE; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MONOCYTE; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

EID: 84881079071     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2013.051     Document Type: Article

References (32)

1. Bokarewa, M. I., Morrissey, J. H. and Tarkowski, A. (2002) Tissue factor as a proinflammatory agent. Arthritis Res. 4, 190-195.
2. Bousette, N., Patel, L., Douglas, S. A., Ohlstein, E. H. and Giaid, A. (2004) Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Atherosclerosis 176, 117-123.
3. Chatterjee, A., Black, S. M. and Catravas, J. D. (2008) Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul. Pharmacol. 49, 134-140.
4. Chen, H., Liu, C., Sun, S., Mei, Y. and Tong, E. (2001) Cytokine-in-duced cell surface expression of adhesion molecules in vascular endothelial cells in vitro. J. Tongji. Med. Univ. 21, 68-71.
5. Cirillo, P., De Rosa, S., Pacileo, M., Gargiulo, A., Angri, V., Fiorentino, I., Prevete, N., Petrillo, G., De Palma, R., Leonardi, A., De Paulis, A. and Chiariello, M. (2008) Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease. J. Thromb. Haemost. 6, 726-736.
6. Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J. C., Connelly, P. W. and Milstone, D. S. A major role for VCAM-1, but not ICAM-1, in early athero sclerosis. J. Clin. Invest. 107, 1255-1262.
7. Douglas, S. A., Tayara, L., Ohlstein, E., Halawa, N. and Giaid, A. (2002) Congestive heart failure and myocardial expression of urotensin II. Lancet 359, 1990-1997.
8. Galkina, E. and Ley, K. (2007) Vascular adhesion molecules in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27, 2292-2301.
9. Grenon, S. M., Aguado-Zuniga, J., Hatton, J. P., Owens, C. D., Conte, M. S. and Hughes-Fulford, M. (2012) Effects of fatty acids on en-dothelial cells: inflammation and monocyte adhesion. J. Surg. Res. 177, e35-e43.
10. Haraldsen, G., Kvale, D., Lien, B., Farstad, I. N. and Brandtzaeg, P. (1996) Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion mol-ecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol. 156, 2558-2565.
11. Harrison, D. G. and Ohara, Y. (1995) Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am. J. Car-diol. 75, 75B-81B.
12. Hassan, G. S., Douglas, S. A., Ohlstein, E. H. and Giaid, A. (2005) Expression of urotensin-II in human coronary atherosclerosis. Pep-tides 26, 2464-2472.
13. Kleemann, R., Zadelaar, S. and Kooistra, T. (2008) Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardio-vasc. Res. 79, 360-376.
14. Kwon, H. M., Choi, Y. J., Choi, J. S., Kang, S. W., Bae, J. Y., Kang, I. J., Jun, J. G., Lee, S. S., Lim, S. S. and Kang, Y. H. (2007) Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. Exp. Biol. Med. (Maywood). 232, 235-245.
15. Lee, H. J., Lee, S. Y., Cho, K., Jeon, B. K., Lee, J. Y., Bae, H. S. and Lee, C. J. (2011) Effect of ambroxol on secretion, production and gene expression of mucin from cultured airway epithelial cells. Bio-mol. Ther. 19, 65-69.
16. Lee, N. Y., Rieckmann, P. and Kang, Y. S. (2012) The changes of p-glycoprotein activity by interferon-γ and tumor necrosis factor-α in primary and immortalized human brain microvascular endothelial cells. Biomol. Ther. 20, 293-298.
17. Libby, P. (2002) Inflammation in atherosclerosis. Nature. 420, 868-874.
18. Loirand, G., Rolli-Derkinderen, M. and Pacaud, P. (2008) Urotensin II and atherosclerosis. Peptides 29, 778-782.
19. Lwaleed, B. A., Cooper, A. J., Voegeli, D. and Getliffe, K. (2007) Tissue factor: a critical role in inflammation and cancer. Biol. Res. Nurs. 9, 97-107.
20. Min, J. K., Kim, Y. M., Kim, S. W., Kwon, M. C., Kong, Y. Y., Hwang, I. K., Won, M. H., Rho, J. and Kwon, Y. G. (2005) TNF-related activation induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. J. Immunol. 175, 531-540.
21. ÓBrien, K. D., McDonald, T. O., Chait, A., Allen, M. D. and Alpers, C. E. (1996) Neovascular expression of E-selectin, intercellular adhesion molecule-1 and vascular adhesion molecule-1 in human atherosclerosis and their relation to intinal leukocyte content. Circulation 93, 672-682.
22. Papadopoulos, P., Bousette, N., Al-Ramli, W., You, Z., Behm, D. J., Ohlstein, E. H., Harrison, S. M., Douglas, S. A. and Giaid, A. (2009) Targeted overexpression of the human urotensin receptor trans-gene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet. Atherosclerosis 204, 395-404.
23. Price, D. T. and Loscalzo, J. (1999) Cellular adhesion molecules and atherogenesis. Am. J. Med. 107, 85-97.
24. Ramos, C. L., Huo, Y., Jung, U., Ghosh, S., Manka, D. R., Sarem-bock, I. J. and Ley, K. (1999) Direct demonstration of P-selectin-and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ. Res. 84, 1237-1244.
25. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809.
26. Steffel, J., Lüscher, T. F. and Tanner, F. C. (2006) Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. Circulation 113, 722-731.
27. Steinberg, D. (2002) Atherogenesis in perspective: hypercholesterol-emia and inflammation as partners in crime. Nat. Med. 8, 1211-1217.
28. Suguro, T., Watanabe, T., Ban, Y., Kodate, S., Misaki, A., Hirano, T., Miyazaki, A. and Adachi, M. (2007) Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension. Am. J. Hypertens. 20, 211-217.
29. Tedgui, A. and Mallat, Z. (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 86, 515-581.
30. Tremoli, E., Camera, M., Toschi, V. and Colli, S. (1999) Tissue factor in atherosclerosis. Atherosclerosis 144, 273-283.
31. Watson, A. M., Olukman, M., Koulis, C., Tu, Y., Samijono, D., Yuen, D., Lee, C., Behm, D. J., Cooper, M. E., Jandeleit-Dahm, K. A., Calkin, C. and Allen, T. J. (2013) Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia 56, 1155-1165.
32. You, Z., Genest, J. Jr, Barrette, P. O., Hafiane, A., Behm, D. J., D'Orleans-Juste, P. and Schwertani, A. G. (2012) Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice. Arterioscler. Thromb. Vasc. Biol. 32, 1809-1816.