Increased Human Urotensin II Levels Are Correlated With Carotid Atherosclerosis in Essential Hypertension

American Journal of Hypertension

Volumn 20, Issue 2, 2007, Pages 211-217

  Suguro, Toshiaki ^a   Watanabe, Takuya ^a   Ban, Yoshiyuki ^b   Kodate, Syuusuke ^a   Misaki, Asako ^a   Hirano, Tsutomu ^a   Miyazaki, Akira ^a   Adachi, Mitsuru ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Showa University Karasuyama Hospital   (Japan)

Author keywords

atherosclerosis; Human urotensin II; hypertension; intima media thickness; plaque score

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLASMA PROTEIN; TRIACYLGLYCEROL; UROTENSIN II; VASOCONSTRICTOR AGENT;

ADULT; AGED; ARTERY DIAMETER; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BODY MASS; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; ESSENTIAL HYPERTENSION; FEMALE; FOAM CELL; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INTIMA; MACROPHAGE; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RISK FACTOR; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; TUNICA MEDIA; VASCULAR SMOOTH MUSCLE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CAROTID ARTERY DISEASES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; TUNICA INTIMA; UROTENSINS;

EID: 33846461155     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2006.08.001     Document Type: Article

References (30)

1. Douglas S.A., and Ohlstein E.H. Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease. Trends Cardiovasc Med 10 (2000) 229-237
2. Watanabe T., Kanome T., Miyazaki A., and Katagiri T. Human urotensin II linking hypertension and coronary artery disease. Hypertens Res 29 (2006) 375-387
3. Cheung B.M., Leung R., Man Y.B., and Wong L.Y. Plasma concentration of urotensin II is raised in hypertension. J Hypertens 22 (2004) 1341-1344
4. Heringlake M., Kox T., Uzun O., Will B., Bahlmann L., Klaus S., Eleftheriadis S., Armbruster F.P., Franz N., and Kraatz E. The relationship between urotensin II plasma immunoreactivity and left ventricular filling pressures in coronary artery disease. Regul Pept 121 (2004) 129-136
5. Totsune K., Takahashi K., Arihara Z., Sone M., Ito S., and Murakami O. Increased plasma urotensin II levels in patients with diabetes mellitus. Clin Sci (Lond) 104 (2003) 1-5
6. Matsushita M., Shichiri M., Imai T., Iwashina M., Tanaka H., Takasu N., and Hirata Y. Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. J Hypertens 19 (2001) 2185-2190
7. Sondermeijer B., Kompa A., Komesaroff P., and Krum H. Effect of exogenous urotensin-II on vascular tone in skin microcirculation of patients with essential hypertension. Am J Hypertens 18 (2005) 1195-1199
8. Maguire J.J., Kuc R.E., Wiley K.E., Kleinz M.J., and Davenport A.P. Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries. Peptides 25 (2004) 1767-1774
9. Bousette N., Patel L., Douglas S.A., Ohlstein E.H., and Giaid A. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Atherosclerosis 176 (2004) 117-123
10. Watanabe T., Suguro T., Kanome T., Sakamoto Y., Kodate S., Hagiwara T., Hongo S., Hirano T., Adachi M., and Miyazaki A. Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages. Hypertension 46 (2005) 738-744
11. Watanabe T., Pakala R., Katagiri T., and Benedict C.R. Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation. J Hypertens 19 (2001) 2191-2196
12. Watanabe T., Pakala R., Katagiri T., and Benedict C.R. Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. Circulation 104 (2001) 16-18
13. Shi L., Ding W., Li D., Wang Z., Jiang H., Zhang J., and Tang C. Proliferation and anti-apoptotic effects of human urotensin II on human endothelial cells. Atherosclerosis 188 (2006) 260-264
14. Tzanidis A., Hannan R.D., Thomas W.G., Onan D., Autelitano D.J., See F., Kelly D.J., Gilbert R.E., and Krum H. Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy. Circ Res 93 (2003) 246-253
15. Watanabe T., Itokawa M., Nakagawa Y., Iguchi T., and Katagiri T. Increased levels of insulin-like growth factor binding protein-3 in hypertensive patients with carotid atherosclerosis. Am J Hypertens 16 (2003) 754-760
16. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo Jr. J.L., Jones D.W., Materson B.J., Oparil S., Wright Jr. J.T., Roccella E.J., National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289 (2003) 2560-2572
17. Kondo K., Kitagawa K., Nagai Y., Yamagami H., Hashimoto H., Hougaku H., and Hori M. Associations of soluble intercellular adhesion molecule-1 with carotid atherosclerosis progression. Atherosclerosis 179 (2005) 155-160
18. Watanabe T., Kanome T., and Miyazaki A. Relationship between hypertension and atherosclerosis: from a viewpoint of the most potent vasoconstrictor human urotensin II. Curr Hypertens Rev 2 (2006) 237-246
19. Suzuki S., Wenyi Z., Hirai M., Hinokio Y., Suzuki C., Yamada T., Yoshizumi S., Suzuki M., Tanizawa Y., Matsutani A., and Oka Y. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japaneses. Peptides 25 (2004) 1803-1808
20. Silvestre R.A., Egido E.M., Hernandez R., Leprince J., Chatenet D., Tollemer H., Chartrel N., Vaudry H., and Marco J. Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas. Eur J Endocrinol 151 (2004) 803-809
21. Watson A.M.D., Lambert G.W., Smith K.J., and May C.N. Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions. Hypertension 42 (2003) 373-379
22. Hassan G.S., Douglas S.A., Ohlstein E.H., and Giaid A. Expression of urotensin-II in human coronary atherosclerosis. Peptides 26 (2005) 2464-2472
23. Katugampola S.D., Kuc R.E., Maguire J.J., and Davenport A.P. G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors. Clin Sci 103 (2002) 171S-175S
24. Wang Z.J., Shi L.B., Xiong Z.W., Zhang L.F., Meng L., Bu D.F., Tang C.S., and Ding W.H. Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout. Peptides 27 (2006) 858-863
25. Rakowski E., Hassan G.S., Dhanak D., Ohlstein E.H., Douglas S.A., and Giaid A. A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker. J Moll Cell Cardiol 39 (2005) 785-791
26. Wang H., Mehta J.L., Chen K., Zhang X., and Li D. Human urotensin II modulates collagen synthesis and the expression of MMP-1 in human endothelial cells. J Cardiovasc Pharmacol 44 (2004) 577-581
27. Sauzeau V., Mellionnec E.L., Bertoglio J., Scalbert E., Pacaud P., and Loirand G. Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 88 (2001) 1102-1104
28. Djordjevic T., BelAiba R.S., Bonello S., Pfeilschifter J., Hess J., and Gorlach A. Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol 25 (2005) 519-525
29. Kang S., Wu Y., and Li X. Effects of statin therapy on the progression of carotid atherosclerosis: a systematic review and meta-analysis. Atherosclerosis 177 (2004) 433-442
30. Uchiyama-Tanaka Y., Mori Y., Kishimoto N., Fukui M., Nose A., Kijima Y., Yamahara H., Hasegawa T., Kosaki A., Matsubara H., and Iwasaka T. Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension. Kidney Blood Press Res 28 (2005) 111-116