Association between behavioral and psychological symptoms and psychotropic drug use among old people with cognitive impairment living in geriatric care settings

International Psychogeriatrics

Volumn 25, Issue 9, 2013, Pages 1415-1423

  Gustafsson, Maria ^a   Sandman, Per Olof ^b   Karlsson, Stig ^a   Gustafson, Yngve ^a   Lövheim, Hugo ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

aggression; BPSD; cognitive impairment; dementia; psychotropic drugs; psychotropic prescribing

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; HYPNOTIC AGENT; NEUROLEPTIC AGENT; NOOTROPIC AGENT; PSYCHOTROPIC AGENT; SEDATIVE AGENT;

AGED; AGGRESSION; ARTICLE; BEHAVIOR DISORDER; COGNITION; COGNITIVE DEFECT; DAILY LIFE ACTIVITY; DRUG USE; FEMALE; GERIATRIC CARE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PREVALENCE;

ACTIVITIES OF DAILY LIVING; AGE FACTORS; AGED; AGGRESSION; AGING; BEHAVIORAL SYMPTOMS; COGNITION DISORDERS; DEMENTIA; FEMALE; HEALTH SERVICES FOR THE AGED; HOMES FOR THE AGED; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; NURSING HOMES; PREVALENCE; PSYCHOTROPIC DRUGS; QUESTIONNAIRES; SOCIAL BEHAVIOR DISORDERS; SWEDEN;

EID: 84881064222     PISSN: 10416102     EISSN: 1741203X     Source Type: Journal    
DOI: 10.1017/S1041610213000859     Document Type: Article

References (28)

1. Adolfsson, R., Gottfries, C. G., Nyström, L. and Winblad, B. (1981). Prevalence of dementia disorders in institutionalized Swedish old people. The workload imposed by caring for these patients. Acta Psychiatrica Scandinavica, 63, 225-244
2. Ashton, H. (2005). The diagnosis and management of benzodiazepine dependence. Current Opinion in Psychiatry, 18, 249-255
3. Ballard, C. G., Waite, J. and Birks, J. (2006). Atypical antipsychotics for aggression and psychosis in Alzheimer's disease. Cochrane Database of Systematic Reviews, CD003476 doi:10.1002/14651858.CD003476.pub2
4. Ballard, C. et al. (2005). Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: Randomised double blind placebo controlled trial. BMJ, 330, 874. doi10.1136/bmj.38369.459988.8F.
5. Banerjee, S. et al. (2011). Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double-blind, placebo-controlled trial. Lancet, 378, 403-411. doi:10.1016/S0140-6736(11)60830-1
6. Cancelli, I., Beltrame, M., Gigli, G. L. and Valente, M. (2009). Drugs with anticholinergic properties: Cognitive and neuropsychiatric side-effects in elderly patients. Neurological Sciences, 30, 87-92. doi:10.1007/s10072-009-0033- y.
7. Cerejeira, J., Lagarto, L. and Mukaetova-Ladinska, E. B. (2012). Behavioral and psychological symptoms of dementia. Frontiers in Neurology, 3, s.73. doi10.3389/fneur.2012.00073
8. Chiu, M-J., Chen, T-F., Yip, P-K., Hua, M-S. and Tang, L-Y. (2006). Behavioral and psychologic symptoms in different types of dementia. Journal of the Formosan Medical Association, 105, 556-562
9. Gauthier, S. et al. (2010). Management of behavioral problems in Alzheimer's disease. International Psychogeriatrics, 22, 346-372. doi:10.1017/S1041610209991505
10. Glass, J., Lanctôt, K. L.,Herrmann, N., Sproule, B. A. and Busto, U. E. (2005). Sedative hypnotics in older people with insomnia: Meta-analysis of risks and benefits. BMJ, 331, 1169. doi:10.1136/bmj.38623.768588.47
11. Gustafsson, M., Karlsson, S. and Lövheim, H. (2013). Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units. BMC Pharmacology & Toxicology, 14, s.10
12. Henry, G., Williamson, D. and Tampi, R. R. (2011). Efficacy and tolerability of antidepressants in the treatment of behavioral and psychological symptoms of dementia, a literature review of evidence. American Journal of Alzheimer's Disease and Other Dementias, 26, 169-183. doi10.1177/ 1533317511402051
13. Lanctôt, K L., Herrmann, N., van Reekum, R., Eryavec, G. and Naranjo, C. A. (2002). Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease. International Journal of Geriatric Psychiatry, 17, 531-541. doi:10.1002/gps.636
14. Lövheim, H., Sandman, P-O., Kallin, K., Karlsson, S. and Gustafson, Y. (2006). Relationship between antipsychotic drug use and behavioral and psychological symptoms of dementia in old people with cognitive impairment living in geriatric care. International Psychogeriatrics, 18, 713-726. doi10.1017/S1041610206003930
15. Lövheim, H., Sandman, P-O., Karlsson, S. and Gustafson, Y. (2008). Behavioral and psychological symptoms of dementia in relation to level of cognitive impairment. International Psychogeriatrics, 20, 777-789. doi10.1017/S1041610208006777
16. Medical Products Agency. (2008). Läkemedelsverkets behandlingsrekommendationer: Läkemedelsbehandling och bemötande vid Beteendemässiga och Psykiska Symtom vid Demenssjukdom - BPSD. Information från läkemedelsverket (25-47). Läkemedelsverket: Stockholm, Sweden (in Swedish
17. Nijk, R. M., Zuidema, S. U. and Koopmans, R. T. C. M. (2009). Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia. International Psychogeriatrics, 21, 485-493. doi10.1017/ S1041610209008916
18. O'Connor, D W., Ames, D., Gardner, B. and King, M. (2009). Psychosocial treatments of psychological symptoms in dementia: A systematic review of reports meeting quality standards. International Psychogeriatrics, 21, 241-251. doi10.1017/S1041610208008223
19. Pollock, B. G. et al. (2002). Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. The American Journal of Psychiatry, 159, 460-465
20. Pollock, B. G. et al. (2007). A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. The American Journal of Geriatric Psychiatry, 15, 942-952
21. Ruths, S., Straand, J., Nygaard, H. A. and Aarsland, D. (2008). Stopping antipsychotic drug therapy in demented nursing home patients: A randomized, placebo-controlled study - the Bergen District Nursing Home Study (BEDNURS). International Journal of Geriatric Psychiatry, 23, 889-895. doi:10.1002/gps.1998
22. Sandman, P O., Adolfsson, R., Norberg, A., Nyström, L. and Winblad, B. (1988). Long-term care of the elderly a descriptive study of 3600 institutionalized patients in the county of Västerbotten, Sweden. Comprehensive Gerontology Section A, Clinical and Laboratory Sciences, 2, 120-132
23. Schneider, L. S., Dagerman, K. S. and Insel, P. (2005). Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials. JAMA, 294, 1934-1943. doi:10.1001/jama. 294.15.1934
24. Schneider, L. S. et al. (2006). Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. The New England Journal of Medicine, 355, 1525-1538. doi10.1056/NEJMoa061240
25. Selbaek, G., Kirkevold, Ø. and Engedal, K. (2008). The course of psychiatric and behavioral symptoms and the use of psychotropic medication in patients with dementia in Norwegian nursing homes - a 12-month follow-up study. The American Journal of Geriatric Psychiatry, 16, 528
26. Statistics Sweden. (2010). Population Statistics. Örebro, Sweden: Statistics Sweden
27. Tariot, P. N., Farlow, M. R., Grossberg, G. T., Graham, S. M., McDonald, S. and Gergel, I. (2004). Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. JAMA, 291, 317-324. doi10.1001/jama.291.3.317
28. Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J. and Koopmans, R. T. C. M. (2011). Psychotropic drug prescription in nursing home patients with dementia: Influence of environmental correlates and staff distress on physicians' prescription behavior. International Psychogeriatrics, 23, 1632-1639. doi10.1017/S1041610211001438