Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from mycobacterium tuberculosis

Biochemistry

Volumn 52, Issue 30, 2013, Pages 5125-5132

  Jennings, Benjamin C ^a   Labby, Kristin J ^a   Green, Keith D ^b   Garneau Tsodikova, Sylvie ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTRANSFERASES; AMINOGLYCOSIDES; BINDING RESIDUES; CLINICAL RESISTANCE; GLOBAL PROBLEMS; INTRACELLULAR SURVIVAL; MYCOBACTERIUM TUBERCULOSIS; SUBSTRATE SPECIFICITY;

ENZYME ACTIVITY;

ACETYLATION;

ALANINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; BACTERIAL PROTEIN; EIS PROTEIN; GLUTAMIC ACID; GLUTAMINE; ISOLEUCINE; KANAMYCIN A; PAROMOMYCIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACETYLATION; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME SPECIFICITY; MUTANT; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

ACETYLATION; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINOGLYCOSIDES; ANTIBIOTICS, ANTITUBERCULAR; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BINDING SITES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; KANAMYCIN; KINETICS; MOLECULAR CONFORMATION; MUTANT PROTEINS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NEBRAMYCIN; PAROMOMYCIN; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 84881063975     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4002985     Document Type: Article

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