Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6

Laboratory Investigation

Volumn 93, Issue 8, 2013, Pages 933-945

  Mohamed, Riyaz ^a   Jayakumar, Calpurnia ^a   Ramesh, Ganesan ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Albuminuria; Chronic kidney disease; EP4 agonist; Inflammation; Nephropathy; Prostaglandin E2

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; CYCLOOXYGENASE 2; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; ONO AE1 329; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL CELL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY MASS; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT DURATION; URINARY EXCRETION;

ALBUMINURIA; ANIMALS; CHEMOKINES; CYCLOOXYGENASE 2; DIABETES MELLITUS, EXPERIMENTAL; DINOPROSTONE; FIBROSIS; HYPERGLYCEMIA; INTERLEUKIN-6; KIDNEY; KIDNEY DISEASES; MACROPHAGES; METHYL ETHERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE;

EID: 84881040828     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.85     Document Type: Article

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