메뉴 건너뛰기




Volumn 91, Issue 3, 2013, Pages 131-139

Transcriptional and posttranscriptional inhibition of HMGCR and PC biosynthesis by geraniol in 2 Hep-G2 cell proliferation linked pathways

Author keywords

Cell proliferation; Geraniol; Hep G2; HMGCR; Phosphatidylcholine

Indexed keywords

3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; CARDIO-VASCULAR DISEASE; CELL-CYCLE PROGRESSION; CHOLESTEROL SYNTHESIS; GERANIOL; HEP-G2; HMGCR; PHOSPHATIDYLCHOLINE;

EID: 84881036464     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2012-0076     Document Type: Article
Times cited : (43)

References (38)
  • 1
    • 10644247842 scopus 로고    scopus 로고
    • 24(S) 25-epoxycholesterol-A potential friend
    • 10.1161/01.ATV.0000148704.72481.28. 15576644.
    • Björkhem I. Diczfalusy D.U. 2004. 24(S) 25-epoxycholesterol-a potential friend. Arterioscler. Thromb. Vasc. Biol. 24: 2209-2210. 10.1161/01.ATV.0000148704.72481.28. 15576644.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 2209-2210
    • Björkhem, I.1    Diczfalusy, D.U.2
  • 2
    • 59649086858 scopus 로고    scopus 로고
    • 24(S),25-epoxycholesterol: A messenger for cholesterol homeostasis
    • 10.1016/j.biocel.2008.05.029. 18725318.
    • Brown A.J. 2009. 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis. Int. J. Biochem. Cell Biol. 41: 744-747. 10.1016/j.biocel.2008.05. 029. 18725318.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 744-747
    • Brown, A.J.1
  • 3
    • 0018761890 scopus 로고
    • Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states
    • 376507.
    • Brown M.S. Goldstein J.L. Dietschy J.M. 1979. Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states. J. Biol. Chem. 254: 5144-5149. 376507.
    • (1979) J. Biol. Chem. , vol.254 , pp. 5144-5149
    • Brown, M.S.1    Goldstein, J.L.2    Dietschy, J.M.3
  • 4
    • 0031056450 scopus 로고    scopus 로고
    • Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol
    • 10.1007/s11745-997-0019-y. 9075204.
    • Burke Y.D. Stark M.J. Roach S.L. Sen S.E. Crowell P.L. 1997. Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids, 32: 151-156. 10.1007/s11745-997-0019-y. 9075204.
    • (1997) Lipids , vol.32 , pp. 151-156
    • Burke, Y.D.1    Stark, M.J.2    Roach, S.L.3    Sen, S.E.4    Crowell, P.L.5
  • 5
    • 4544364825 scopus 로고    scopus 로고
    • Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts
    • 10.1016/j.canlet.2004.06.019. 15374632.
    • Carnesecchi S. Bras-Goncalves R. Bradaia A. Zeisel M. Gosse F. Poupon M.F. Raul F. 2004. Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 215: 53-59. 10.1016/j.canlet.2004.06.019. 15374632.
    • (2004) Cancer Lett. , vol.215 , pp. 53-59
    • Carnesecchi, S.1    Bras-Goncalves, R.2    Bradaia, A.3    Zeisel, M.4    Gosse, F.5    Poupon, M.F.6    Raul, F.7
  • 6
    • 0019429532 scopus 로고
    • Regulation of cholesterol biosynthesis in enucleated cells
    • 7204371.
    • Cavenee W.K. Chen H.W. Kandutsch A.A. 1981. Regulation of cholesterol biosynthesis in enucleated cells. J. Biol. Chem. 256: 2675-2681. 7204371.
    • (1981) J. Biol. Chem. , vol.256 , pp. 2675-2681
    • Cavenee, W.K.1    Chen, H.W.2    Kandutsch, A.A.3
  • 7
    • 78049286711 scopus 로고    scopus 로고
    • Geraniol-A review of a commercially important fragrance material
    • 10.1016/j.sajb.2010.05.008.
    • Chen W. Viljoen A.M. 2010. Geraniol-A review of a commercially important fragrance material. S. Afr. J. Bot. 76: 643-651. 10.1016/j.sajb.2010.05.008.
    • (2010) S. Afr. J. Bot. , vol.76 , pp. 643-651
    • Chen, W.1    Viljoen, A.M.2
  • 8
    • 80054065083 scopus 로고    scopus 로고
    • Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2-and ubiquitin-dependent mechanisms
    • 10.1016/j.febslet.2011.09.012. 21944868.
    • Cho S.Y. Jun H.J. Lee J.H. Jia Y. Kim K.H. Lee S.J. 2011. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2-and ubiquitin-dependent mechanisms. FEBS Lett. 585: 3289-3296. 10.1016/j.febslet.2011.09.012. 21944868.
    • (2011) FEBS Lett. , vol.585 , pp. 3289-3296
    • Cho, S.Y.1    Jun, H.J.2    Lee, J.H.3    Jia, Y.4    Kim, K.H.5    Lee, S.J.6
  • 9
    • 34447107008 scopus 로고    scopus 로고
    • The effect of essential oils of dietary wormwood (Artemisia princeps), with and without added vitamin E, on oxidative stress and some genes involved in cholesterol metabolism
    • 10.1016/j.fct.2007.01.021. 17368686.
    • Chung M.J. Kang A.Y. Park S.O. Park K.W. Jun H.J. Lee S.J. 2007. The effect of essential oils of dietary wormwood (Artemisia princeps), with and without added vitamin E, on oxidative stress and some genes involved in cholesterol metabolism. Food Chem. Toxicol. 45: 1400-1409. 10.1016/j.fct.2007. 01.021. 17368686.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1400-1409
    • Chung, M.J.1    Kang, A.Y.2    Park, S.O.3    Park, K.W.4    Jun, H.J.5    Lee, S.J.6
  • 10
    • 37349057813 scopus 로고    scopus 로고
    • Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice
    • 10.1017/S0007114507798926. 17697428.
    • Chung M.J. Park K.W. Kim K.H. Kim C.T. Baek J.P. Bang K.H. et al. 2008. Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methyl- glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br. J. Nutr. 99: 67-75. 10.1017/S0007114507798926. 17697428.
    • (2008) Br. J. Nutr. , vol.99 , pp. 67-75
    • Chung, M.J.1    Park, K.W.2    Kim, K.H.3    Kim, C.T.4    Baek, J.P.5    Bang, K.H.6
  • 11
    • 0028307290 scopus 로고
    • Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • 8021239.
    • Correll C.C. Ng L. Edwards P.A. 1994. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 269: 17390-17393. 8021239.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17390-17393
    • Correll, C.C.1    Ng, L.2    Edwards, P.A.3
  • 12
    • 84881031385 scopus 로고    scopus 로고
    • Crowell, P.L. and Elson, C.E. 2001. Isoprenoids, health and disease. In Handbook of Nutraceuticals and Functional Foods. Edited by R.E.C. Wildman. New York: CRC Press. pp. 31-53.
    • Crowell, P.L., and Elson, C.E. 2001. Isoprenoids, health and disease. In Handbook of Nutraceuticals and Functional Foods. Edited by R.E.C. Wildman. New York: CRC Press. pp. 31-53.
  • 13
    • 4644256898 scopus 로고    scopus 로고
    • Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity
    • 10.1016/j.bcp.2004.06.022. 15450939.
    • Duncan R.E. Lau D. El-Sohemy A. Archer M.C. 2004. Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. Biochem. Pharmacol. 68: 1739-1747. 10.1016/j.bcp.2004.06. 022. 15450939.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1739-1747
    • Duncan, R.E.1    Lau, D.2    El-Sohemy, A.3    Archer, M.C.4
  • 14
    • 0032851111 scopus 로고    scopus 로고
    • Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway
    • 10.1146/annurev.biochem.68.1.157. 10872447.
    • Edwards P.A. Ericsson J. 1999. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu. Rev. Biochem. 68: 157-185. 10.1146/annurev.biochem.68.1.157. 10872447.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 157-185
    • Edwards, P.A.1    Ericsson, J.2
  • 15
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • 13428781.
    • Folch J. Lees M. SloaneStanley G.H. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509. 13428781.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloanestanley, G.H.3
  • 16
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • 10.1038/343425a0. 1967820.
    • Goldstein J.L. Brown M.S. 1990. Regulation of the mevalonate pathway. Nature, 343: 425-430. 10.1038/343425a0. 1967820.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 17
    • 0028216631 scopus 로고
    • Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins
    • 10.1016/0005-2760(94)90200-3. 8199197.
    • Grunler J. Ericsson J. Dallner G. 1994. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim. Biophys. Acta, 1212: 259-577. 10.1016/0005-2760(94)90200-3. 8199197.
    • (1994) Biochim. Biophys. Acta , vol.1212 , pp. 259-577
    • Grunler, J.1    Ericsson, J.2    Dallner, G.3
  • 18
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • 10.1172/JCI200215593. 11994399.
    • Horton J.D. Goldstein J.L. Brown M.S. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109: 1125-1131. 10.1172/JCI200215593. 11994399.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 19
    • 73249114946 scopus 로고    scopus 로고
    • Molecular Mechanisms involved in Farnesol-Induced Apoptosis
    • 10.1016/j.canlet.2009.05.015. 19520495.
    • Joo J.H. Jetten A.M. 2010. Molecular Mechanisms involved in Farnesol-Induced Apoptosis. Cancer Lett. 287: 123-135. 10.1016/j.canlet.2009.05. 015. 19520495.
    • (2010) Cancer Lett. , vol.287 , pp. 123-135
    • Joo, J.H.1    Jetten, A.M.2
  • 20
    • 0036275530 scopus 로고    scopus 로고
    • Caspase processing and nuclear export of CTP:Phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis
    • 10.1128/MCB.22.13.4851-4862.2002. 12052891.
    • Lagace T.A. Miller J.R. Ridgway N.D. 2002. Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. Mol. Cell. Biol. 22: 4851-4862. 10.1128/MCB.22.13.4851-4862.2002. 12052891.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4851-4862
    • Lagace, T.A.1    Miller, J.R.2    Ridgway, N.D.3
  • 22
    • 0032476029 scopus 로고    scopus 로고
    • Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells
    • 10.1074/jbc.273.40.26179. 9748300.
    • Miquel K. Pradines A. Terce F. Selmi S. Favre G. 1998. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. J. Biol. Chem. 273: 26179-26186. 10.1074/jbc.273.40. 26179. 9748300.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26179-26186
    • Miquel, K.1    Pradines, A.2    Terce, F.3    Selmi, S.4    Favre, G.5
  • 23
    • 0032906921 scopus 로고    scopus 로고
    • Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids
    • 10203554.
    • Mo H. Elson C.E. 1999. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J. Nutr. 129: 804-813. 10203554.
    • (1999) J. Nutr. , vol.129 , pp. 804-813
    • Mo, H.1    Elson, C.E.2
  • 24
    • 3042736080 scopus 로고    scopus 로고
    • Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
    • 15229351.
    • Mo H. Elson C.E. 2004. Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp. Biol. Med. (Maywood), 229: 567-585. 15229351.
    • (2004) Exp. Biol. Med. (Maywood) , vol.229 , pp. 567-585
    • Mo, H.1    Elson, C.E.2
  • 25
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • 10.1016/0022-1759(83)90303-4. 6606682.
    • Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65: 55-63. 10.1016/0022-1759(83)90303-4. 6606682.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 28
    • 0037229435 scopus 로고    scopus 로고
    • Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level
    • 12514264.
    • Peffley D.M. Gayen A.K. 2003. Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level. J. Nutr. 133: 38-44. 12514264.
    • (2003) J. Nutr. , vol.133 , pp. 38-44
    • Peffley, D.M.1    Gayen, A.K.2
  • 29
    • 84881061643 scopus 로고    scopus 로고
    • Phillips, H.J. 1973. Dye exclusion tests for cell viability. In Tissue Culture: Methods and Applications. Edited by P.F. Kruse and M.K. Patterson. New York: Academic Press. pp. 406-408.
    • Phillips, H.J. 1973. Dye exclusion tests for cell viability. In Tissue Culture: Methods and Applications. Edited by P.F. Kruse and M.K. Patterson. New York: Academic Press. pp. 406-408.
  • 30
    • 33645415249 scopus 로고    scopus 로고
    • Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
    • 10.1139/o05-160. 16462894.
    • Polo M.P. de Bravo M.G. 2006. Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. Biochem. Cell Biol. 84: 102-111. 10.1139/o05-160. 16462894.
    • (2006) Biochem. Cell Biol. , vol.84 , pp. 102-111
    • Polo, M.P.1    De Bravo, M.G.2
  • 31
    • 80051671114 scopus 로고    scopus 로고
    • Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line
    • 10.1002/cbf.1772. 21735455.
    • Polo M.P. Crespo R. de Bravo M.G. 2011. Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. Cell Biochem. Funct. 29: 452-458. 10.1002/cbf.1772. 21735455.
    • (2011) Cell Biochem. Funct. , vol.29 , pp. 452-458
    • Polo, M.P.1    Crespo, R.2    De Bravo, M.G.3
  • 32
    • 0028158306 scopus 로고
    • Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol
    • 10.1016/0304-3835(94)90396-4. 8149348.
    • Ren Z. Gould M.N. 1994. Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. Cancer Lett. 76: 185-190. 10.1016/0304-3835(94)90396-4. 8149348.
    • (1994) Cancer Lett. , vol.76 , pp. 185-190
    • Ren, Z.1    Gould, M.N.2
  • 33
    • 0018342385 scopus 로고
    • Inactive 3-hydroxy-3-methylglutaryl-coenzyme A reductase in broken cell preparations of various mammalian tissues and cell cultures
    • 10.1016/0005-2760(79)90162-0. 35236.
    • Saucier S.E. Kandutsch A.A. 1979. Inactive 3-hydroxy-3-methylglutaryl- coenzyme A reductase in broken cell preparations of various mammalian tissues and cell cultures. Biochim. Biophys. Acta, 572: 541-556. 10.1016/0005-2760(79) 90162-0. 35236.
    • (1979) Biochim. Biophys. Acta , vol.572 , pp. 541-556
    • Saucier, S.E.1    Kandutsch, A.A.2
  • 34
    • 0016357487 scopus 로고
    • Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts
    • 4441486.
    • Shapiro D.J. Nordstrom J.L. Mitschelen J.J. Rodwell V.W. Schimke R.T. 1974. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim. Biophys. Acta, 370: 369-377. 4441486.
    • (1974) Biochim. Biophys. Acta , vol.370 , pp. 369-377
    • Shapiro, D.J.1    Nordstrom, J.L.2    Mitschelen, J.J.3    Rodwell, V.W.4    Schimke, R.T.5
  • 35
    • 0022346351 scopus 로고
    • 24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis
    • 4055739.
    • Spencer T.A. Gayen A.K. Phirwa S. Nelson J.A. Taylor F.R. Kandutsch A.A. Erickson S.K. 1985. 24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis. J. Biol. Chem. 260: 13391-13394. 4055739.
    • (1985) J. Biol. Chem. , vol.260 , pp. 13391-13394
    • Spencer, T.A.1    Gayen, A.K.2    Phirwa, S.3    Nelson, J.A.4    Taylor, F.R.5    Kandutsch, A.A.6    Erickson, S.K.7
  • 36
    • 33644799048 scopus 로고    scopus 로고
    • A novel inhibitor of oxidosqualene:Lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content
    • 10.1161/01.ATV.0000189158.28455.94. 16210564.
    • Telford D.E. Lipson S.M. Barret P.H.R. Sutherland B.G. Edwards J.Y. Aebi J.D. et al. 2005. A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content. Arterioscler. Thromb. Vasc. Biol. 25: 2608-2614. 10.1161/01.ATV.0000189158.28455.94. 16210564.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2608-2614
    • Telford, D.E.1    Lipson, S.M.2    Barret, P.H.R.3    Sutherland, B.G.4    Edwards, J.Y.5    Aebi, J.D.6
  • 37
    • 38149138153 scopus 로고    scopus 로고
    • Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis
    • 10.1074/jbc.M706416200. 17981807.
    • Wong J. Quinn C.M. Gelissen I.C. Brown A.J. 2008. Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. J. Biol. Chem. 283: 700-707. 10.1074/jbc.M706416200. 17981807.
    • (2008) J. Biol. Chem. , vol.283 , pp. 700-707
    • Wong, J.1    Quinn, C.M.2    Gelissen, I.C.3    Brown, A.J.4
  • 38
    • 0028843982 scopus 로고
    • Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice
    • 7472655.
    • Yu S.G. Hildebrandt L.A. Elson C.E. 1995. Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J. Nutr. 125: 2763-2767. 7472655.
    • (1995) J. Nutr. , vol.125 , pp. 2763-2767
    • Yu, S.G.1    Hildebrandt, L.A.2    Elson, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.