Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): Studies utilizing human and mouse colonic preparations

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 305, Issue 3, 2013, Pages

  Kumar, Jeyan S ^a,b   Subramanian, Veedamali S ^a,b   Kapadia, Rubina ^a,b   Kashyap, Moti L ^b   Said, Hamid M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Colonic uptake; Human organic anion transporter 10; Microbiota; Nicotinic acid; Transport

Indexed keywords

BUCLADESINE; CALMODULIN; GENISTIN; NICOTINAMIDE; NICOTINIC ACID; ORGANIC ANION TRANSPORTER; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ANION TRANSPORT; APICAL MEMBRANE; ARTICLE; COLONOCYTE; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTESTINE CELL; LARGE INTESTINE; MICROFLORA; MOUSE; NONHUMAN; NUTRIENT UPTAKE; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 84881006250     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00148.2013     Document Type: Article

References (35)

1. Abu-Qurshin R, Naschitz JE, Zuckermann E, Nash E, Eldar S, Yeshurun D. Crohn's disease associated with pellagra and increased excretion of 5-hydroxyindolacetic acid. Am J Med Sci 313: 111-113, 1997.
2. Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 283: 16332-16341, 2008.
3. Coates ME, Ford JE, Harrison GF. Intestinal synthesis of vitamins of the B complex in chicks. Br J Nutr 22: 493-500, 1968.
4. Flachowsky G. Niacin in dairy and beef cattle nutrition. Arch Anim Nutr 43: 195-213, 1993.
5. Ganji SH, Zhang L, Kamanna VS, Kahyap ML. Effect of niacin on lipoprotein and atherosclerosis. Future Lipidol 1: 549-557, 2006.
6. Ghosal A, Lambrecht N, Subramanya SB, Kapadia R, Said HM. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Am J Physiol Gastrointest Liver Physiol 304: G64-G71, 2013.
7. Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5: e9199, 2010.
8. Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, Ganapathy V. Transport of nicotinate and structurally related compound by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm Res 24: 575-584, 2007.
9. Harries AD, Heatley RV. Nutritional disturbances in Crohn's disease. Postgrad Med J 59: 690-697, 1983.
10. Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SMR, Singer D, Andreas R, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487: 477-481, 2012.
11. Hopfer U, Nelson K, Perrotto J, Isselbacher KJ. Glucose transport in isolated brush border membrane from rat small intestine. J Biol Chem 248: 25-32, 1973.
12. Ijichi H, Ichiyama A, Hayaishi O. Studies on the biosynthesis of nicotinamide adenine dinucleotide. III. Comparative in vivo studies on nicotinic acid nicotinamide and quinolinic acid as precursors of nicotinamide adenine dinucleotide. J Biol Chem 241: 3701-3707, 1966.
13. Ikeda M, Tsuji H, Nakamura S, Ichiyama A, Nishizuka Y, Hayaishi O. Studies on the biosynthesis of nicotinamide adenine dinucleotide: a role of picolinic carboxylase in the biosynthesis of nicotinamide adenine dinucleotide from tryptophan in mammals. J Biol Chem 240: 1395-1401, 1965.
14. Kleta R, Romeo E, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggerman T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A. Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet 36: 999-1002, 2004.
15. Kumar CK, Moyer MP, Dudeja PK, Said HM. A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. J Biol Chem 272: 6226-6231, 1997.
16. Livek KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta DeltaC(T)) method. Methods 25: 402-408, 2001.
17. Mahajan RJ, Baldwin ML, Harig JM, Ramaswamy K, Dudeja PK. Chloride transport in human proximal colonic apical membrane vesicles. Biochim Biophys Acta 1280: 12-18, 1996.
18. Meyers CD, Kamanna VS, Kashyap ML. Niacin therapy in atherosclerosis. Curr Opin Lipidol 15: 659-665, 2004.
19. Meyers CD, Kashyap ML. Management of the metabolic syndromenicotinic acid. Endocrinol Metab Clin North Am 33: 557-575, 2004.
20. Morris MC, Schneider JA, Tangney CC. Thoughts on B-vitamins and dementia. J Alzheimers Dis 9: 429-433, 2006.
21. Nabokina SM, Kashyap ML, Said HM. Mechanism and regulation of human intestinal niacin uptake. Am J Physiol Cell Physiol 289: C97-C103, 2005.
22. O'Sullivan MG, Thornton G, O'Sullivan GC, Collins JK. Probiotic bacteria: myth or reality? Food Sci Technol Int 3: 309-314, 1992.
23. Pollack S, Enat R, Haim S, Zinder O, Barzilai D. Pellagra as the presenting manifestation of Crohn's disease. Gastroenterology 82: 948- 952, 1982.
24. Rasic JL, Kurmann JA. Bifodobacteria and their role. Microbiological, nutritional-physiological, medical, and technological aspects and bibliography. Experientia Suppl 39: 1-295, 1983.
25. Reidling JC, Lambrecht N, Kassir M, Said HM. Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology 138: 1802-1809, 2010.
26. Rosmaniho A, Sanches M, Fernandes IC, Pinto-Almeida T, Vilaça S, Oliveira A, Selores M. Letter: Pellagra as the initial presentation of Crohn's disease. Dermatol Online J 18: 12, 2012.
27. Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437: 357-372, 2011.
28. Said HM, Nexo E. Intestinal absorption of water-soluble vitamins. In: Physiology of the Gastrointestinal Tract, 5th ed, edited by Johnson LR, Ghishan FK, Merchand JL, Said HM, and Wood JD. San Diego, CA: Elsevier Press; 2012, pp. 1711-1756.
29. Segal I, Ou TL, Demetriou A, Paterson A, Hale M, Lerios M. Rectal manifestations of pellagra. Int J Colorectal Dis 1: 238-243, 1986.
30. Simanjuntak MT, Tamai I, Terasaki Tsuji AT. Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport. J Pharmacobio-Dyn 13: 301-309, 1990.
31. Stratigos JD, Katsambas A. Pellagra: a still existing disease. Br J Dermatol 96: 99-106, 1977.
32. Subramanya SB, Subramanian VS, Sekar VT, Said HM. Thiamin uptake by pancreatic cells: Effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol 301: G896-G904, 2011.
33. Wilkinson GN. Statistical estimation in enzyme kinetics. Biochem J 80: 324-332, 1961.
34. Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB. Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem 278: 9869-9874, 2003.
35. Wrong OM, Edmonds CJ, Chadwick VS. The Large Intestine: Its Role in Mammalian Nutrition and Homeostasis. Hoboken, NJ: Wiley and Sons, 1981.