Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4

Blood

Volumn 121, Issue 20, 2013, Pages 4082-4089

  Lee, Jennifer ^a   Shieh, Jae Hung ^b   Zhang, Jianxuan ^a   Liu, Liren ^a   Zhang, Yue ^a   Eom, Jae Yong ^a   Morrone, Giovanni ^c   Moore, Malcolm A S ^b   Zhou, Pengbo ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CUL4 PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; HOX PROTEIN; HOXB4 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CUL4A PROTEIN, HUMAN; CULLIN; HOMEODOMAIN PROTEIN; HOXB4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL EXPANSION; CELL PROLIFERATION; COLONY FORMING CELL; CONTROLLED STUDY; EX VIVO STUDY; HELA CELL LINE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; STEM CELL SELF-RENEWAL; UBIQUITINATION; ADULT; ADULT STEM CELL; ANIMAL; CELL CULTURE; CULTURE TECHNIQUE; FEASIBILITY STUDY; GENETICS; HELA CELL; HUMAN; METABOLISM; METHODOLOGY; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; PRIMARY CELL CULTURE; PROTEIN ENGINEERING; TRANSGENIC MOUSE;

ADULT; ADULT STEM CELLS; ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CULLIN PROTEINS; FEASIBILITY STUDIES; HELA CELLS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; PRIMARY CELL CULTURE; PROTEIN ENGINEERING; PROTEOLYSIS; TRANSCRIPTION FACTORS;

MLCS; MLOWN;

EID: 84881003977     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-09-455204     Document Type: Article

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