Acute lesions that impair affective empathy

Brain

Volumn 136, Issue 8, 2013, Pages 2539-2549

  Leigh, Richard ^a   Oishi, Kenichi ^a   Hsu, John ^a   Lindquist, Martin ^b   Gottesman, Rebecca F ^a,b   Jarso, Samson ^a   Crainiceanu, Ciprian ^b   Mori, Susumu ^a   Hillis, Argye E ^a,c,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Emotion perception; Empathy; Magnetic resonance imaging; Prosody; Stroke

Indexed keywords

ADULT; AFFECT; AGED; AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; ANTERIOR INSULA; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; CLINICAL ARTICLE; COMPREHENSION; CONTROLLED STUDY; EMPATHY; FEMALE; HUMAN; MALE; MIDDLE FRONTAL GYRUS; MIDDLE TEMPORAL GYRUS; ORBITAL CORTEX; PRECUNEUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RIGHT HEMISPHERE; SEX RATIO; STRUCTURE ACTIVITY RELATION; SUPERIOR FRONTAL GYRUS; SUPERIOR TEMPORAL GYRUS; TASK PERFORMANCE; TEMPORAL LOBE;

EID: 84880960196     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt177     Document Type: Article

References (60)

1. Balconi M, Bortolotti A. Empathy in cooperative versus non-cooperative situations: the contribution of self-report measures and autonomic responses. Appl Psychophysiol Biofeedback 2012; 37: 161-9.
2. Bodini B, Iacoboni M, Lenzi GL. Acute stroke effects on emotions: an interpretation through the mirror system. Curr Opin Neurol 2004; 17: 55-60.
3. Brune M, Brune-Cohrs U. Theory of mind-evolution, ontogeny, brain mechanisms and psychopathology. Neurosci Biobehav Rev 2006; 30: 437-55.
4. Brunnlieb C, Munte TF, Tempelmann C, Heldmann M. Vasopressin modulates neural responses related to emotional stimuli in the right amygdala. Brain Res 2013; 1499: 29-42.
5. Bzdok D, Schilbach L, Vogeley K, Schneider K, Laird AR, Langner R, et al. Parsing the neural correlates of moral cognition: ALE meta-analysis on morality, theory of mind, and empathy. Brain Struct Funct 2012; 217: 783-96.
6. Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci USA 2003; 100: 5497-502.
7. Caviness V, Makris N, Montinaro E, Sahin N, Bates J, Schwamm L, et al. Anatomy of stroke, Part I: An MRI-based topographic and volumetric system of analysis. Stroke 2002; 33: 2549-56.
8. Corbetta M, Patel G, Shulman GL. The reorienting system of the human brain: from environment to theory of mind. Neuron 2008; 58: 306-24.
9. Couto B, Sedeno L, Sposato LA, Sigman M, Riccio PM, Salles A, et al. Insular networks for emotional processing and social cognition: comparison of two case reports with either cortical or subcortical involvement. Cortex 2013; 49: 1420-34.
10. Cox CL, Uddin LQ, Di MA, Castellanos FX, Milham MP, Kelly C. The balance between feeling and knowing: affective and cognitive empathy are reflected in the brain's intrinsic functional dynamics. Soc Cogn Affect Neurosci 2012; 7: 727-37.
11. Dara C, Kirsch-Darrow L, Ochfeld E, Slenz J, Agranovich A, Vasconcellos-Faria A, et al. Impaired emotion processing from vocal and facial cues in frontotemporal dementia compared to right hemisphere stroke. Neurocase 2012. Advance Access published on July 25, 2012.
12. Davis MH. Measuring individual differences in empathy: evidence for a multidimensional approach. J Pers Soc Psychol 1983; 44: 113-26.
13. de Waal FB. The antiquity of empathy. Science 2012; 336: 874-6.
14. Decety J, Chaminade T. When the self represents the other: a new cognitive neuroscience view on psychological identification. Conscious Cogn 2003; 12: 577-96.
15. Decety J, Jackson PL. The functional architecture of human empathy. Behav Cogn Neurosci Rev 2004; 3: 71-100.
16. Decety J, Lamm C. The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition. Neuroscientist 2007; 13: 580-93.
17. Dziobek I, Rogers K, Fleck S, Bahnemann M, Heekeren HR, Wolf OT, et al. Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the multifaceted empathy test (MET). J Autism Dev Disord 2008; 38: 464-73.
18. Eslinger PJ. Neurological and neuropsychological bases of empathy. Eur Neurol 1998; 39: 193-9.
19. Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M. Metacognitive deficits in frontotemporal dementia. J Neurol Neurosurg Psychiatry 2005; 76: 1630-5.
20. Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsych Clin Neurosci 2011; 23: 74-82.
21. Fellows LK, Heberlein AS, Morales DA, Shivde G, Waller S, Wu DH. Method matters: an empirical study of impact in cognitive neuroscience. J Cogn Neurosci 2005; 17: 850-8.
22. Finley A, Saver J, Alger J, Pregenzer M, Leary M, Ovbiagele B. Diffusion weighted imaging assessment of insular vulnerability in acute middle cerebral artery infarctions [abstract]. Stroke 2003; 34: 259. discussion.
23. Gorno-Tempini ML, Pradelli S, Serafini M, Pagnoni G, Baraldi P, Porro C, et al. Explicit and incidental facial expression processing: an fMRI study. Neuroimage 2001; 14: 465-73.
24. Gu X, Gao Z, Wang X, Liu X, Knight RT, Hof PR, et al. Anterior insular cortex is necessary for empathetic pain perception. Brain 2012; 135: 2726-35.
25. Hurlemann R, Patin A, Onur OA, Cohen MX, Baumgartner T, Metzler S, et al. Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. J Neurosci 2010; 30: 4999-5007.
26. Hynes CA, Baird AA, Grafton ST. Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking. Neuropsychologia 2006; 44: 374-83.
27. Jimura K, Konishi S, Asari T, Miyashita Y. Temporal pole activity during understanding other persons' mental states correlates with neuroticism trait. Brain Res 2010; 1328: 104-12.
28. Kipps CM, Hodges JR. Theory of mind in frontotemporal dementia. Soc Neurosci 2006; 1: 235-44.
29. Lamm C, Decety J, Singer T. Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage 2011; 54: 2492-502.
30. Lee SE, Seeley WW, Poorzand P, Rademakers R, Karydas A, Stanley CM, et al. Clinical characterization of bvFTD due to FUS neuropathology. Neurocase 2012; 18: 305-17.
31. Lee J, Zaki J, Harvey PO, Ochsner K, Green MF. Schizophrenia patients are impaired in empathic accuracy. Psychol Med 2011; 41: 2297-304.
32. Leopold A, Krueger F, Dal Monte O, Pardini M, Pulaski SJ, Solomon J, et al. Damage to the left ventromedial prefrontal cortex impacts affective theory of mind. Soc Cogn Affect Neurosci 2012; 7: 871-80.
33. McDonald S, Flanagan S. Social perception deficits after traumatic brain injury: interaction between emotion recognition, mentalizing ability and social communication. Neuropsychology 2004; 18: 572-9.
34. Narvid J, Gorno-Tempini ML, Slavotinek A, Dearmond SJ, Cha YH, Miller BL. Of brain and bone: the unusual case of Dr A. Neurocase 2009; 15: 190-205.
35. Neumann D, Zupan B, Babbage DR, Radnovich AJ, Tomita M, Hammond F, et al. Affect recognition, empathy and dysosmia after traumatic brain injury. Arch Phys Med Rehabil 2012; 93: 1414-20.
36. Oishi K, Faria A, Jiang H, Li X, Akhter K, Zhang J, et al. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants. Neuroimage 2009; 46: 486-99.
37. Ota H, Fujii T, Suzuki K, Fukatsu R, Yamadori A. Dissociation of bodycentered and stimulus-centered representations in unilateral neglect. Neurology 2001; 57: 2064-9.
38. Rankin KP, Gorno-Tempini ML, Allison SC, Stanley CM, Glenn S, Weiner MW, et al. Structural anatomy of empathy in neurodegenerative disease. Brain 2006; 129 (Pt 11): 2945-56.
39. Rankin KP, Kramer JH, Miller BL. Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol 2005; 18: 28-36.
40. Roldan GE, Cerquetti D, Tenca E, Leiguarda R. The impact of bilateral cerebellar damage on theory of mind, empathy and decision making. Neurocase 2011; 17: 270-5.
41. Ross ED, Monnot M. Neurology of affective prosody and its functionalanatomic organization in right hemisphere. Brain Lang 2008; 104: 51-74.
42. Ross ED, Thompson RD, Yenkosky J. Lateralization of affective prosody in brain and the callosal integration of hemispheric language functions. Brain Lang 1997; 56: 27-54.
43. Samson D, Apperly IA, Chiavarino C, Humphreys GW. Left temporoparietal junction is necessary for representing someone else's belief. Nat Neurosci 2004; 7: 499-500.
44. Samson D, Apperly IA, Humphreys GW. Error analyses reveal contrasting deficits in 'theory of mind': neuropsychological evidence from a 3-option false belief task. Neuropsychologia 2007; 45: 2561-9.
45. Samson D, Apperly IA, Kathirgamanathan U, Humphreys GW. Seeing it my way: a case of a selective deficit in inhibiting self-perspective. Brain 2005; 128: 1102-11.
46. Saxe R, Carey S, Kanwisher N. Understanding other minds: linking developmental psychology and functional neuroimaging. Annu Rev Psychol 2004; 55: 87-124.
47. Saxe R, Kanwisher N. People thinking about thinking people. The role of the temporo-parietal junction in 'theory of mind'. Neuroimage 2003; 19: 1835-42.
48. Schnell K, Bluschke S, Konradt B, Walter H. Functional relations of empathy and mentalizing: an fMRI study on the neural basis of cognitive empathy. Neuroimage 2011; 54: 1743-54.
49. Sebastian CL, Fontaine NM, Bird G, Blakemore SJ, Brito SA, McCrory EJ, et al. Neural processing associated with cognitive and affective theory of mind in adolescents and adults. Soc Cogn Affect Neurosci 2012; 7: 53-63.
50. Shamay-Tsoory SG. The neural bases for empathy. Neuroscientist 2011; 17: 18-24.
51. Shamay-Tsoory SG, Aharon-Peretz J. Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study. Neuropsychologia 2007; 45: 3054-67.
52. Shamay-Tsoory SG, Aharon-Peretz J, Levkovitz Y. The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res 2007; 90: 274-83.
53. Shamay-Tsoory SG, Aharon-Peretz J, Perry D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 2009; 132: 617-27.
54. Shamay-Tsoory SG, Tomer R, Berger BD, Aharon-Peretz J. Characterization of empathy deficits following prefrontal brain damage: the role of the right ventromedial prefrontal cortex. J Cogn Neurosci 2003; 15: 324-37.
55. Shamay-Tsoory SG, Tomer R, Berger BD, Goldsher D, Aharon-Peretz J. Impaired 'affective theory of mind' is associated with right ventromedial prefrontal damage. Cogn Behav Neurol 2005; 18: 55-67.
56. Stone VE, Baron-Cohen S, Calder A, Keane J, Young A. Acquired theory of mind impairments in individuals with bilateral amygdala lesions. Neuropsychologia 2003; 41: 209-20.
57. Stotland E, Dunn RE. Empathy, self-esteem and birth order. J Abnorm Soc Psychol 1963; 66: 532-40.
58. Stuss DT, Anderson V. The frontal lobes and theory of mind: developmental concepts from adult focal lesion research. Brain Cogn 2004; 55: 69-83.
59. Thompson-Schill SL, Swick D, Farah MJ, D'Esposito M, Kan IP, Knight RT. Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings. Proc Natl Acad Sci USA 1998; 95: 15855-60.
60. Viskontas IV, Possin KL, Miller BL. Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior. Ann N Y Acad Sci 2007; 1121: 528-45.