Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter: An efficacious orally-administered mucosal vaccine against salmonellosis in pigs

Vaccine

Volumn 31, Issue 36, 2013, Pages 3695-3701

  Gradassi, Matteo ^a   Pesciaroli, Michele ^b   Martinelli, Nicola ^a   Ruggeri, Jessica ^a   Petrucci, Paola ^b   Hassan, Walid Hamdy ^b,c   Raffatellu, Manuela ^d   Scaglione, Frine Eleonora ^e   Ammendola, Serena ^f   Battistoni, Andrea ^f   Alborali, Giovanni L ^a   Pasquali, Paolo ^b  

^a ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL EMILIA ROMAGNA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c Shamla St next to the Directorate of Roads and Bridges   (Egypt)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF TURIN   (Italy)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Mucosal vaccine; Oral delivery; Pigs; S. Typhimurium znuABC; Salmonella; Salmonellosis; Vaccine

Indexed keywords

BACTERIAL VACCINE; FORMALDEHYDE; MUCOSAL VACCINE; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER ZNUABC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; CONTROLLED STUDY; DIARRHEA; FEMALE; FEVER; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; VACCINATION;

MUCOSAL VACCINE; ORAL DELIVERY; PIGS; S. TYPHIMURIUM ΔZNUABC; SALMONELLA; SALMONELLOSIS; VACCINE;

ADMINISTRATION, ORAL; ANIMALS; BACTERIAL PROTEINS; BACTERIAL SHEDDING; CATION TRANSPORT PROTEINS; FECES; FEMALE; IMMUNITY, MUCOSAL; INTERFERON-GAMMA; MOUTH MUCOSA; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SALMONELLA VACCINES; SUS SCROFA; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, ATTENUATED; VIRULENCE;

EID: 84880954746     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.05.105     Document Type: Article

References (26)

1. Haagsma J.A., Havelaar A.H., Janssen B.M., Bonsel G.J. Disability Adjusted Life Years and minimal disease: application of a preference-based relevance criterion to rank enteric pathogens. Popul Health Metr 2008, 6:7.
2. Pires S.M., de Knegt L., Hald T. Estimation of the relative contribution of different food and animal sources to human Salmonella infections in the European Union 2011, European Food Safety Authority. http://www.efsa.europa.eu/en/supporting/doc/184e.pdf.
3. Anon Report of the task force on zoonoses data collection on the analysis of the baseline survey of the prevalence of Salmonella in slaughter pigs, Part A. EFSA J 2008, 135:1-111.
4. Vico J.P., Mainer-Jaime R.C. The use of meat juice or blood serum for the diagnosis of Salmonella infection in pigs and its possible implications on Salmonella control programs. J Vet Diagn Invest 2011, 23:528-531.
5. Poulin M.C., Donadeu M., Macklay E.K., Penman K.L., Thomson J.R. Comparative study of three porcine Salmonella ELISAs. Vet Rec 2010, 166:500-501.
6. Wilhelm E., Hilbert F., Paulsen P., Smulders F.J., Rossmanith W. Salmonella diagnosis in pig production: methodological problems in monitoring the prevalence in pigs and pork. J Food Prot 2007, 70:1246-1248.
7. Beloeil P.A., Chauvin C., Proux K., Fablet C., Madec F., Alioum A. Risk factors for Salmonella seroconversion of fattening pigs in farrow-to-finish herds. Vet Res 2007, 38:835-848.
8. Berends B.R., Urlings H.A., Snijders J.M., Van Knapen F. Identification and quantification of risk factors in animal management and transport regarding Salmonella spp. in pigs. Int J Food Microbiol 1996, 30:37-53.
9. Montesissa C. Natural alternatives to antibiotic growth promoters in Europe. J Vet Pharmacol Ther 2006, 29:45-46.
10. 2+ uptake system ZnuABC is required for bacterial zinc homeostasis in intracellular environments and contributes to virulence of Salmonella enterica. Infect Immun 2007, 75:5867-5876.
11. Pasquali P., Ammendola S., Pistoia C., Petrucci P., Tarantino M., Valente C., et al. Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter confers immune-based protection against challenge infections in mice. Vaccine 2008, 26:3421-3426.
12. Pesciaroli M., Aloisio F., Ammendola S., Pistoia C., Petrucci P., Tarantino M., et al. An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection. Vaccine 2011, 29:1783-1790.
13. Pesciaroli M., Gradassi M., Zanoni M.G., Martinelli N., Ruggeri J., Pistoia C., et al. Salmonella Typhimurium lacking the ZnuABC transporter is safe and immunogenic in pigs. Vaccine 2013, April. PII: S0264-410X(13)00471-4. 10.1016/j.vaccine.2013.04.032.
14. Wales A.D., Cook A.J., Davies R.H. Producing Salmonella-free pigs: a review focusing on interventions at weaning. Vet Rec 2011, 168:267-276.
15. Nollet N., Maes D., Duchateau L., Hautekiet V., Houf K., Van Hoof J., et al. Discrepancies between the isolation of Salmonella from mesenteric lymph nodes and the results of serological screening in slaughter pigs. Vet Res 2005, 36:545-555.
16. Denagamage T.N., O'Connor A.M., Sargeant J.M., Rajić A., McKean J.D. Efficacy of vaccination to reduce Salmonella prevalence in live and slaughtered swine: a systematic review of literature from 1979 to 2007. Foodborne Pathog Dis 2007, 4:539-549.
17. Schwarz P., Kich J.D., Kolb J., Cardoso M. Use of an avirulent live Salmonella Choleraesuis vaccine to reduce the prevalence of Salmonella carrier pigs at slaughter. Vet Rec 2011, 169:551-552.
18. Farzan A., Friendship R.M. A clinical field trial to evaluate the efficacy of vaccination in controlling Salmonella infection and the association of Salmonella-shedding and weight gain in pigs. Can J Vet Res 2010, 74:258-263.
19. Chu C.Y., Wang S.Y., Chen Z.W., Chien M.S., Huang J.P., Chen J.J., et al. Heterologous protection in pigs induced by a plasmid-cured and crp gene-deleted Salmonella choleraesuis live vaccine. Vaccine 2007, 25:7031-7040.
20. Dougan G., John V., Palmer S., Mastroeni P. Immunity to salmonellosis. Immunol Rev 2011, 240:196-210.
21. Griffin A.J., McSorley S.J. Generation of Salmonella-specific Th1 cells requires sustained antigen stimulation. Vaccine 2011, 29:2697-2704.
22. Santos R.L., Raffatellu M., Bevins C.L., Adams L.G., Tükel C., Tsolis R.M., et al. Life in the inflamed intestine, Salmonella style. Trends Microbiol 2009, 17:498-506.
23. Schaible U.E., Kaufmann S.H. A nutritive view on the host-pathogen interplay. Trends Microbiol 2005, 13:373-380.
24. Kehl-Fie T.E., Skaar E.P. Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol 2010, 14:218-224.
25. Petrarca P., Ammendola S., Pasquali P., Battistoni A. The Zur-regulated ZinT protein is an auxiliary component of the high-affinity ZnuABC zinc transporter that facilitates metal recruitment during severe zinc shortage. J Bacteriol 2010, 192:1553-1564.
26. Liu J.Z., Jellbauer S., Poe A., Pesciaroli M., Kehl-Fie T., Hosking M., et al. Zinc Sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe 2012, 11:227-239.